公开(公告)号：JPH04210924A

公开(公告)日：1992-08-03

申请号：JP1683291

申请日：1991-01-18

Applicant: SCLAVO SPA

Inventor： FUIRITSUPO RATSUTANTSUI ,  MAURITSUIO CHIEKETSUTEIN ,  RITSUKARUDO BUANNI

IPC: A61K9/00 ,  A61K9/20 ,  A61K38/23 ,  A61K47/26 ,  A61K47/36 ,  A61K47/38 ,  A61P3/00

Abstract: PURPOSE: To obtain a pharmaceutical composition capable of providing blood concentration having same level as blood concentration of calcitonin obtainable by conventional intramuscular administration by oral administration at same unit dosage form by homogenizing with a mixture of solid excipients. CONSTITUTION: Perbuccal or sublingual tablets for oral administration contain calcitonin homogenized with a mixture of solid excipients, preferably completely a soluble diluent (especially mannitol, lactose or saccharose), a disintegrator (especially starch, its derivative, micro-crystalline cellulose, its derivative, crospovidone, amberlite, alginic acid) and a lubricant (especially magnesium stearate, aluminum stearate, stearic acid, talc, high molecular weight ethylene glycol) or the above diluent and a binder (especially gum arabic, hydroxypropyl cellulose or hydroxypropylmethyl cellulose) and lubricant, e.g. eel calcitonin in an amount of 20-800I.U., preferably 50-500I.U. per tablet as an active ingredient.

公开(公告)号：JPH03190824A

公开(公告)日：1991-08-20

申请号：JP30895790

申请日：1990-11-16

Applicant: SCLAVO SPA

Inventor： FUIRITSUPO RATSUTANTSUI ,  RITSUKARUDO BUANNI

IPC: A61K9/08 ,  A61K9/48 ,  A61K38/23 ,  A61K47/10 ,  A61K47/34 ,  A61K47/42 ,  A61P3/00

Abstract: PURPOSE: To obtain a stable pharmaceutical preparation suitable for preparation of capsules for rectal administration by dispersing calcitonin and, as necessary, as stabilizer into a liquid vehicle comprising polyethylene glycol and a polyhydric alcohol. CONSTITUTION: This pharmaceutical preparation is obtained by dispersing (C) calcitonin in an amount of 20-800IU, preferably 50-500IU based on 1ml preparation, and necessary, (D) a stabilizer, preferably albumin in an amount of 0.01-1.2mg, preferably 0.05-1.0mg based on 1IU component C into a uniform liquid vehicle comprising (A) polyethylene glycol in an amount of >=75wt.%, especially >=85wt.% based on total weight of the preparation and (B) an alcohol having at least two hydroxy groups, preferably propylene glycol, ethylene glycol, sorbitol, especially glycerol in an amount of