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公开(公告)号：DE69024839T2
公开(公告)日：1996-05-30
申请号：DE69024839
申请日：1990-04-18
Applicant: SCLAVO SPA
Inventor： MARIOTTI SABINA , SISTO ALESSANDRO , NENCIONI LUCIANO , VILLA LUIGI , VERDINI ANTONIO SILVIO , PESSI ANTONELLO
IPC: A61K31/195 , A61K38/00 , A61P37/00 , C07C279/12 , C07C279/14 , C07K1/06 , C07K5/02 , C07K5/06 , C07K5/08 , C07K7/02 , A61K31/215
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公开(公告)号：CA1336738C
公开(公告)日：1995-08-15
申请号：CA616330
申请日：1992-01-13
Applicant: ENIRICERCHE SPA , SCLAVO SPA
Inventor： SISTO ALESSANDRO , VERDINI ANTONIO SILVIO
Abstract: Intermediates of formulas (V), (VI) and (VII): (V) (VI) (VII) wherein pL represents a protective group of the side-chain amino function, PG is a suitable protecting group of the guanidino function, P is a carboxyl protecting group, R3 may represent a group -OR2 wherein R2 is hydrogen or a hydrocarbyl radical, a group -OP wherein P is a carboxyl protecting group, or a grouping of formula (IV): (IV) wherein P is as defined above, and PI is a protective group of tyrosine hydroxyl function for the preparation of new retro-inverso analogs of thymopentin (TP5) of general formula RNH-gArg-mLys-Asp-R1 where R is hydrogen or an acyl radical, and R1 is an -OR2 group where R2 is as defined above.
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公开(公告)号：DE69017771T2
公开(公告)日：1995-07-13
申请号：DE69017771
申请日：1990-06-20
Applicant: SCLAVO SPA
Inventor： MARIOTTI SABINA , SISTO ALESSANDRO , NENCIONI LUCIANO , VILLA LUIGI , PESSI ANTONELLO
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公开(公告)号：DE69017771D1
公开(公告)日：1995-04-20
申请号：DE69017771
申请日：1990-06-20
Applicant: SCLAVO SPA
Inventor： MARIOTTI SABINA , SISTO ALESSANDRO , NENCIONI LUCIANO , VILLA LUIGI , PESSI ANTONELLO
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公开(公告)号：ES2061958T3
公开(公告)日：1994-12-16
申请号：ES89203230
申请日：1989-12-18
Applicant: SCLAVO SPA
Inventor： MARIOTTI SABINA , SISTO ALESSANDRO , NENCIONI LUCIANO , VILLA LUIGI , VERDINI ANTONIO SILVIO
IPC: A61K31/195 , A61K31/215 , A61K31/22 , A61K38/00 , A61P37/00 , A61P43/00 , C07C279/12 , C07K5/02 , C07K7/02
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Patent Agency Ranking
公开(公告)号：DE3887362T2
公开(公告)日：1994-05-11
申请号：DE3887362
申请日：1988-03-09
Applicant: ENIRICERCHE SPA , SCLAVO SPA
Inventor： SISTO ALESSANDRO , VERDINI ANTONIO SILVIO
IPC: A61K38/00 , A61P37/00 , C07C67/00 , C07C239/00 , C07C279/12 , C07C301/00 , C07C311/64 , C07K1/06 , C07K1/113 , C07K5/02 , C07K5/08 , C07K7/02
Abstract: New retro-inverso analogs of thymopentin (TP5) and of its tripeptide fragment (TP5 ) of general formula (I) are described wherein R is hydrogen or an acyl radical, and R is -OR or wherein R is hydrogen or a hydrocarbyl radical, and the corresponding pharmaceutically acceptable acid- or base-addition salts. The new compounds are enzyme-resistant immunomodulatory peptides.
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公开(公告)号：CA2020129A1
公开(公告)日：1990-12-31
申请号：CA2020129
申请日：1990-06-29
Applicant: SCLAVO SPA
Inventor： MARIOTTI SABINA , SISTO ALESSANDRO , NENCIONI LUCIANO , VILLA LUIGI , PESSI ANTONELLO
IPC: A61K38/22 , A61K38/00 , A61P11/14 , A61P37/00 , C07K1/06 , C07K5/02 , C07K5/08 , C07K7/02 , C07K5/083 , A61K38/06
Abstract: CASE 3076 NEW ANALOGUES OF ALL-BOND RETROINVERTED THYMOPENTIN, THE METHOD FOR THE SYNTHESIS OF THE SAME AND THEIR EMPLOYMENT FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS New thymopentin (TP5) analogues whose bonds in the peptide chain are all retro-inverted are disclosed. Such new compounds have the following general formula (I) (I) wherein R is hydrogen or an acyl radical, and R1 is a group of the formula -OR2, wherein R2 is a hydrogen atom or a hydrocarbon radical, and the corresponding basic or acid addition salts which are pharmaceutically acceptable. The new compounds have immunostimulating activity.
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公开(公告)号：AT119913T
公开(公告)日：1995-04-15
申请号：AT90201609
申请日：1990-06-20
Applicant: SCLAVO SPA
Inventor： MARIOTTI SABINA , SISTO ALESSANDRO , NENCIONI LUCIANO , VILLA LUIGI , PESSI ANTONELLO
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公开(公告)号：DE68913936T2
公开(公告)日：1994-07-07
申请号：DE68913936
申请日：1989-12-18
Applicant: SCLAVO SPA
Inventor： MARIOTTI SABINA , SISTO ALESSANDRO , NENCIONI LUCIANO , VILLA LUIGI , VERDINI ANTONIO SILVIO
IPC: A61K31/195 , A61K31/215 , A61K31/22 , A61K38/00 , A61P37/00 , A61P43/00 , C07C279/12 , C07K5/02 , C07K7/02
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公开(公告)号：DE68913936D1
公开(公告)日：1994-04-21
申请号：DE68913936
申请日：1989-12-18
Applicant: SCLAVO SPA
Inventor： MARIOTTI SABINA , SISTO ALESSANDRO , NENCIONI LUCIANO , VILLA LUIGI , VERDINI ANTONIO SILVIO
IPC: A61K31/195 , A61K31/215 , A61K31/22 , A61K38/00 , A61P37/00 , A61P43/00 , C07C279/12 , C07K5/02 , C07K7/02
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