公开(公告)号：DE69024839T2

公开(公告)日：1996-05-30

申请号：DE69024839

申请日：1990-04-18

Applicant: SCLAVO SPA

Inventor： MARIOTTI SABINA ,  SISTO ALESSANDRO ,  NENCIONI LUCIANO ,  VILLA LUIGI ,  VERDINI ANTONIO SILVIO ,  PESSI ANTONELLO

IPC: A61K31/195 ,  A61K38/00 ,  A61P37/00 ,  C07C279/12 ,  C07C279/14 ,  C07K1/06 ,  C07K5/02 ,  C07K5/06 ,  C07K5/08 ,  C07K7/02 ,  A61K31/215

公开(公告)号：DE69017771T2

公开(公告)日：1995-07-13

申请号：DE69017771

申请日：1990-06-20

Applicant: SCLAVO SPA

Inventor： MARIOTTI SABINA ,  SISTO ALESSANDRO ,  NENCIONI LUCIANO ,  VILLA LUIGI ,  PESSI ANTONELLO

IPC: A61K38/22 ,  A61K38/00 ,  A61P11/14 ,  A61P37/00 ,  C07K1/06 ,  C07K5/02 ,  C07K5/08 ,  C07K7/02

公开(公告)号：ES2052517T3

公开(公告)日：1994-07-16

申请号：ES87109318

申请日：1987-06-29

Applicant: ENIRICERCHE SPA ,  SCLAVO SPA

Inventor： VERDINI ANTONIO SILVIO ,  BONELLI FABIO ,  PESSI ANTONELLO ,  CARDINALI FRANCO ,  BORASCHI DIANA ,  CENSINI STEFANO ,  DI TRAPANI ROMANO

IPC: A61K39/39 ,  A61K38/00 ,  A61K38/43 ,  A61P31/04 ,  A61P35/00 ,  A61P37/04 ,  C07C271/22 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/078 ,  C07K5/10 ,  C07K1/00 ,  A61K37/02

Abstract: New partially retro-inverted tuftsin analogues of general formula I wherein R represents the side-chain of the amino acids threonine, methionine or leucine R represents the side-chain of the amino acids lysine or arginine R is hydrogen or a metabolically labile acyl group, all the asymmetric carbon atoms are either of the S- or R-configuration, or, alternatively, the first, third, and fourth asymmetric carbons, starting from the N-terminal residue, are of the S-configuration while the second one is of the R- or (R,S)-configuration, and the corresponding pharmacologically acceptable salts, esters and amides. The new compounds which share the same pharmacological properties of tuftsin, are much more stable toward the enzymatic degradation than the parent molecule.

公开(公告)号：DE3783280D1

公开(公告)日：1993-02-11

申请号：DE3783280

申请日：1987-06-29

Applicant: ENIRICERCHE SPA ,  SCLAVO SPA

Inventor： VERDINI ANTONIO SILVIO ,  BONELLI FABIO ,  PESSI ANTONELLO ,  CARDINALI FRANCO ,  BORASCHI DIANA ,  CENSINI STEFANO ,  DI TRAPANI ROMANO

IPC: A61K39/39 ,  A61K38/00 ,  A61K38/43 ,  A61P31/04 ,  A61P35/00 ,  A61P37/04 ,  C07C271/22 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/078 ,  C07K5/10 ,  C07K1/00 ,  A61K37/02

Abstract: New partially retro-inverted tuftsin analogues of general formula I wherein R represents the side-chain of the amino acids threonine, methionine or leucine R represents the side-chain of the amino acids lysine or arginine R is hydrogen or a metabolically labile acyl group, all the asymmetric carbon atoms are either of the S- or R-configuration, or, alternatively, the first, third, and fourth asymmetric carbons, starting from the N-terminal residue, are of the S-configuration while the second one is of the R- or (R,S)-configuration, and the corresponding pharmacologically acceptable salts, esters and amides. The new compounds which share the same pharmacological properties of tuftsin, are much more stable toward the enzymatic degradation than the parent molecule.

公开(公告)号：AT84044T

公开(公告)日：1993-01-15

申请号：AT87109318

申请日：1987-06-29

Applicant: ENIRICERCHE SPA ,  SCLAVO SPA

Inventor： VERDINI ANTONIO SILVIO ,  BONELLI FABIO ,  PESSI ANTONELLO ,  CARDINALI FRANCO ,  BORASCHI DIANA ,  CENSINI STEFANO ,  DI TRAPANI ROMANO

IPC: C07K1/00 ,  C07K5/02 ,  A61K37/02

公开(公告)号：IT9021565A1

公开(公告)日：1992-03-26

申请号：IT2156590

申请日：1990-09-25

Applicant: SCLAVO SPA

Inventor： PESSI ANTONELLO ,  RAPPUOLI PAOLO ,  SCAPOL LUCIA ,  VISCOMI GIUSEPPE CLAUDIO

IPC: A61K20060101 ,  C07C20060101

公开(公告)号：DE3582786D1

公开(公告)日：1991-06-13

申请号：DE3582786

申请日：1985-12-12

Applicant: ENIRICERCHE SPA ,  SCLAVO SPA

Inventor： BONELLI FABIO ,  PESSI ANTONELLO ,  VERDINI ANTONIO SILVIO

IPC: C07K1/113 ,  A61K38/00 ,  A61P9/08 ,  A61P9/12 ,  C07K5/06 ,  C07K7/02 ,  C07K7/06

公开(公告)号：AT63317T

公开(公告)日：1991-05-15

申请号：AT85115888

申请日：1985-12-12

Applicant: ENIRICERCHE SPA ,  SCLAVO SPA

Inventor： BONELLI FABIO ,  PESSI ANTONELLO ,  VERDINI ANTONIO SILVIO

IPC: C07K1/113 ,  A61K38/00 ,  A61P9/08 ,  A61P9/12 ,  C07K5/06 ,  C07K7/02 ,  C07K7/06

公开(公告)号：IT8621145D0

公开(公告)日：1986-07-16

申请号：IT2114586

申请日：1986-07-16

Applicant: ENIRICERCHE SPA ,  SCLAVO SPA

Inventor： VERDINI ANTONIO SILVIO ,  BONELLI FABIO ,  PESSI ANTONELLO ,  CARDINALI FRANCO ,  BORASCHI DIANO ,  CENSINI STEFANO

IPC: A61K20060101 ,  A61K

公开(公告)号：AT119913T

公开(公告)日：1995-04-15

申请号：AT90201609

申请日：1990-06-20

Applicant: SCLAVO SPA

Inventor： MARIOTTI SABINA ,  SISTO ALESSANDRO ,  NENCIONI LUCIANO ,  VILLA LUIGI ,  PESSI ANTONELLO

IPC: A61K38/22 ,  A61K38/00 ,  A61P11/14 ,  A61P37/00 ,  C07K1/06 ,  C07K5/02 ,  C07K5/08 ,  C07K7/02