公开(公告)号：FR2821842B1

公开(公告)日：2003-05-09

申请号：FR0103068

申请日：2001-03-07

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  BENOIST ALAIN ,  LEFOULON FRANCOIS ,  HICKMAN JOHN ,  PIERRE ALAIN ,  TUCKER GORDON ,  BRIDON DOMINIQUE ,  EZRIN ALAN ,  HOLMES DARREN ,  HUANG XICAI

IPC: A61P35/00 ,  C07D471/04 ,  A61K31/437 ,  A61K31/4375 ,  C07D471/14

公开(公告)号：FR2821842A1

公开(公告)日：2002-09-13

申请号：FR0103068

申请日：2001-03-07

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  BENOIST ALAIN ,  LEFOULON FRANCOIS ,  HICKMAN JOHN ,  PIERRE ALAIN ,  TUCKER GORDON ,  BRIDON DOMINIQUE ,  EZRIN ALAN ,  HOLMES DARREN ,  HUANG XICAI

IPC: A61P35/00 ,  C07D471/04 ,  A61K31/437 ,  A61K31/4375 ,  C07D471/14

Abstract: The invention concerns a compound of general formula (I), wherein: R1, R'1, identical or different, represent a hydrogen atom or an alkyl group; R2 represents a hydroxy or NHOH group; R3 represents one or the other of the following groups (II), such as defined in the description; A represents a nitrogenous heterocycle aromatic or not, saturated or unsaturated, monocyclic or bicyclic, optionally containing one or several heteroatoms; m represents an integer between 0 and 6 inclusive; n represents an integer between 1 and 6 inclusive; s represents 0 or 1; B represents an alkylene bond or chain wherein one or several -CH2- groups are optionally substituted by an oxygen, sulphur atom or a NR group; R4 represents a group capable of forming a covalent bond with mobile proteins of the blood, their isomers and their addition salts with a pharmaceutically acceptable acid or a base. The invention is useful for preparing medicines.