公开(公告)号：JP2003113156A

公开(公告)日：2003-04-18

申请号：JP2002203408

申请日：2002-07-12

Applicant: SERVIER LAB

Inventor： LAVIELLE GILBERT ,  DUBUFFET THIERRY ,  CIMETIERE BERNARD ,  VERBEUREN TONY ,  SIMONET SERGE ,  VAYSSETTES-COURCHAY CHRISTINE

IPC: C07D295/08 ,  A61K31/18 ,  A61K31/195 ,  A61K31/40 ,  A61K31/445 ,  A61K31/454 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5375 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P25/06 ,  C07B53/00 ,  C07C303/40 ,  C07C311/16 ,  C07C311/17 ,  C07C311/19 ,  C07C311/21 ,  C07D207/08 ,  C07D211/00 ,  C07D261/20 ,  C07D265/30 ,  C07D275/04 ,  C07D275/06 ,  C07D295/088 ,  C07D295/092 ,  C07D413/04 ,  C07D417/04

Abstract: PROBLEM TO BE SOLVED: To provide a medicine useful for treatment of atherothrombotic cardiovascular diseases such as cardiac infarction, stenocardia, cerebrovascular diseases, etc. SOLUTION: This compound is represented by the formula (I) [wherein G is a group represented by the formula (II) (R and R each independently represent hydrogen atom, an alkyl group or the like or R and R form a heterocycloalkyl group together with nitrogen atom) or the like; R represents hydrogen atom, an alkyl group or the like; Ra is hydroxy group, a 1-6C alkoxy group or amino group; Rb and Rc are same or different and each represents hydrogen atom, a halogen atom, an alkyl group or the like; m is an integer of 0-1; n and q are same or different integer of 0-6; p and r are same or different integer of 1-6]. This pharmaceutical composition comprises the compound.

公开(公告)号：JP2002356486A

公开(公告)日：2002-12-13

申请号：JP2002114443

申请日：2002-04-17

Applicant: SERVIER LAB

Inventor： LAVIELLE GILBERT ,  DUBUFFET THIERRY ,  MULLER OLIVIER ,  MILLAN MARK ,  DEKEYNE ANNE ,  BROCCO MAURICETTE

IPC: A61K31/519 ,  A61P1/14 ,  A61P15/10 ,  A61P15/12 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D471/00 ,  C07D471/04 ,  C07D491/048 ,  C07D491/052 ,  C07D513/00 ,  C07D519/00

Abstract: PROBLEM TO BE SOLVED: To provide a medicine useful for treatment of depression, impulsive behavioral disorder, anxiety, schizophrenia, Parkinson's disease, dysgnosia, libido dysfunction, sexual dysfunction, appetite disorder and somnipathy due to α2 /5-HT2c antagonist characteristics possessed thereby. SOLUTION: This compound is represented by the formula (I) [wherein, R1 , R2 , R3 and R4 denote each hydrogen atom or the like; X denotes oxygen atom or the like; A denotes a linear or a branched (1-6C) alkylene chain; ring-B denotes an unsaturated nitrogen-containing heterocyclic ring; and R5 denotes a linear or a branched (1-6C) alkyl chain], its enantiomer and diastereoisomer and its addition salt with a pharmaceutically acceptable acid or base. The method for preparing the same and the pharmaceutical composition comprising the same are provided.

公开(公告)号：WO2005012333A3

公开(公告)日：2005-03-24

申请号：PCT/FR2004002035

申请日：2004-07-29

Applicant: SERVIER LAB ,  FUGIER CLAUDE ,  DUBUFFET THIERRY ,  LANGLOIS PASCAL

Inventor： FUGIER CLAUDE ,  DUBUFFET THIERRY ,  LANGLOIS PASCAL

IPC: A61K38/00 ,  C07D209/42 ,  C07K5/06

CPC classification number: C07K5/06026 ,  A61K38/00 ,  C07D209/42

Abstract: A method for the synthesis of perindopril of formula(I) and the pharmaceutically acceptable salts thereof.

Abstract translation: 用于合成式（I）的培哚普利及其药学上可接受的盐的方法。

公开(公告)号：WO2004082357A3

公开(公告)日：2004-10-28

申请号：PCT/FR2004000593

申请日：2004-03-12

Applicant: SERVIER LAB ,  DUBUFFET THIERRY ,  LECOUVE JEAN-PIERRE

Inventor： DUBUFFET THIERRY ,  LECOUVE JEAN-PIERRE

IPC: C07D209/42 ,  C07D225/00 ,  C07K5/06 ,  C07K5/02

CPC classification number: C07K5/06026 ,  C07D209/42 ,  Y02P20/55

Abstract: The invention relates to a method of the synthesis of compounds of formula (I), where R1 = H, alkyl or benzyl and R2 = an amine protecting group. The above is of application to the synthesis of perindopril and the pharmaceutically-acceptable salts thereof.

Abstract translation: 本发明涉及合成式（I）化合物的方法，其中R 1 = H，烷基或苄基且R 2 =胺保护基。 以上内容适用于培哚普利及其药学上可接受的盐的合成。

公开(公告)号：WO2005012328A3

公开(公告)日：2005-03-24

申请号：PCT/FR2004002036

申请日：2004-07-29

Applicant: SERVIER LAB ,  FUGIER CLAUDE ,  DUBUFFET THIERRY ,  LANGLOIS PASCAL

Inventor： FUGIER CLAUDE ,  DUBUFFET THIERRY ,  LANGLOIS PASCAL

IPC: A61K38/00 ,  C07D209/42 ,  C07K5/06

CPC classification number: C07K5/06026 ,  A61K38/00 ,  C07D209/42

Abstract: A method for the synthesis of perindropol of formula (1) and the pharmaceutically acceptable salts thereof.

Abstract translation: 一种用于合成式（1）的perindropol及其药学上可接受的盐的方法。

公开(公告)号：WO2005005461A3

公开(公告)日：2005-03-31

申请号：PCT/FR2004001638

申请日：2004-06-28

Applicant: SERVIER LAB ,  DUBUFFET THIERRY ,  LECOUVE JEAN-PIERRE

Inventor： DUBUFFET THIERRY ,  LECOUVE JEAN-PIERRE

IPC: C07D209/42 ,  C07K5/02 ,  C07K5/06

CPC classification number: C07K5/0222 ,  C07D209/42 ,  C07K5/06026

Abstract: A method for the synthesis of perindopril of formula (I) and the pharmaceutically acceptable salts thereof.

Abstract translation: 合成式（I）的培哚普利的方法及其药学上可接受的盐。

公开(公告)号：WO2004078708A3

公开(公告)日：2004-10-14

申请号：PCT/FR2004000445

申请日：2004-02-27

Applicant: SERVIER LAB ,  DUBUFFET THIERRY ,  LANGLOIS PASCAL

Inventor： DUBUFFET THIERRY ,  LANGLOIS PASCAL

IPC: C07D209/42 ,  C07K5/02 ,  C07K5/06

CPC classification number: C07K5/0222 ,  C07D209/42 ,  C07K5/06026 ,  Y02P20/55

Abstract: The invention relates to a method for synthesising compounds of the formula (I), wherein R1 is a hydrogen atom or an alkyl or benzyl group, and R2 is amine function protecting group. The use of said compounds for synthesising perindopril and the pharmaceutically acceptable salts thereof is also disclosed.

Abstract translation: 本发明涉及一种合成式（I）化合物的方法，其中R 1为氢原子或烷基或苄基，R 2为胺官能保护基。 还公开了所述化合物用于合成培哚普利及其药学上可接受的盐的用途。

公开(公告)号：WO2004078707A3

公开(公告)日：2004-10-14

申请号：PCT/FR2004000444

申请日：2004-02-27

Applicant: SERVIER LAB ,  DUBUFFET THIERRY ,  LANGLOIS PASCAL

Inventor： DUBUFFET THIERRY ,  LANGLOIS PASCAL

IPC: C07D209/42

CPC classification number: C07D209/42 ,  Y02P20/55

Abstract: The invention relates to a method for synthesising derivatives of the formula (I), wherein R is a hydrogen atom or an amine function-protecting group. The use of said derivatives for synthesising perindopril and the pharmaceutically acceptable salts thereof is also disclosed.

Abstract translation: 本发明涉及用于合成式（I）的衍生物的方法，其中R是氢原子或胺官能团保护基团。 还公开了所述衍生物用于合成培哚普利及其药学上可接受的盐的用途。

公开(公告)号：MY160226A

公开(公告)日：2017-02-28

申请号：MYPI2010000320

申请日：2008-08-01

Applicant: SERVIER LAB

Inventor： DUBUFFET THIERRY ,  LECOUVE JEAN-PIERRE ,  HERMET JEAN-PAUL

IPC: C07C231/02 ,  C07C233/18 ,  C07C253/14 ,  C07C255/37

Abstract: PROCESS FOR THE INDUSTRIAL SYNTHESIS OF THE COMPOUND OF FORMULA (I) APPLICATION IN THE SYNTHESIS OF AGOMELATINE.

公开(公告)号：ES2467690T3

公开(公告)日：2014-06-12

申请号：ES08842551

申请日：2008-08-01

Applicant: SERVIER LAB

Inventor： DUBUFFET THIERRY ,  LECOUVE JEAN-PIERRE ,  HERMET JEAN-PAUL

IPC: C07C231/02 ,  C07C233/18 ,  C07C253/14 ,  C07C255/37

Abstract: Procedimiento de síntesis industrial del compuesto de fórmula (I) **Fórmula** caracterizado porque se somete a reacción ácido 7-metoxi-1-naftoico, de fórmula (III): **Fórmula** que se somete a la acción de un agente reductor, para obtener el compuesto de fórmula (IV): **Fórmula** compuesto de fórmula (IV) cuya función OH se transforma en un grupo saliente y que se somete a reacción con un reactivo de cianación para obtener el compuesto de fórmula (I), que se aísla en forma de un sólido.