公开(公告)号：WO2004048340A8

公开(公告)日：2005-07-07

申请号：PCT/EP0314841

申请日：2003-11-26

Applicant: SHANGHAI INST MATERIA MEDICA ,  SERVIER LAB ,  QIN GUO-WEI ,  TANG XI-CAN ,  WANG RUI ,  ZHOU TIAN-XI ,  LESTAGE PIERRE ,  CAIGNARD DANIEL-HENRI ,  RENARD PIERRE

Inventor： QIN GUO-WEI ,  TANG XI-CAN ,  WANG RUI ,  ZHOU TIAN-XI ,  LESTAGE PIERRE ,  CAIGNARD DANIEL-HENRI ,  RENARD PIERRE

IPC: C07D221/28 ,  A61K31/485 ,  C07D489/00

CPC classification number: C07D221/28

Abstract: The invention relates to sinomenine and compounds thereof and also to compounds of formula (I), wherein R1 represents an alkyl group; R2 represents a hydrogen atom or an alkylcarbonyl group, an haloalkylcarbonyl group or an arylcarbonyl; Y represents a group (II), (III) or (IV); R3 ,R4, R'4, R5, R'5 and R6 are as defined in the description; and X represents a halogen atom. Medicaments.

Abstract translation: 本发明涉及青藤碱及其化合物，还涉及式（I）化合物，其中R 1表示烷基; R2表示氢原子或烷基羰基，卤代烷基羰基或芳基羰基; Y代表（II），（III）或（IV）; R3，R4，R'4，R5，R'5和R6如说明书中所定义; X表示卤素原子。 药物。

公开(公告)号：NO20053139L

公开(公告)日：2005-06-27

申请号：NO20053139

申请日：2005-06-27

Applicant: SERVIER LAB

Inventor： RENARD PIERRE ,  LESTAGE PIERRE ,  CAIGNARD DANIEL-HENRI ,  TANG XI-CAN ,  QIN GUO-WEI ,  WANG RUI ,  ZHOU TIAN-XI

IPC: C07D221/28 ,  A61K31/485

Abstract: The invention relates to sinomenine and compounds thereof and also to compounds of formula (I): wherein R 1 represents alkyl, R 2 represents hydrogen or alkylcarbonyl, haloalkylcarbonyl or arylcarbonyl, Y represents a group R 3 , R 4 , R' 4 , R 5 , R' 5 and R 6 are as defined in the description, and X represents halogen and medicinal products containing the same which are useful in treating mnemocognitive disorders.

公开(公告)号：AU2003242278A1

公开(公告)日：2004-01-06

申请号：AU2003242278

申请日：2003-06-16

Applicant: SERVIER LAB ,  SHANGHAI INST OF MATERIA MEDICA

Inventor： QIN GUO-WEI ,  TANG XI-CAN ,  LESTAGE PIERRE ,  CAIGNARD DANIEL-HENRI ,  RENARD PIERRE

IPC: A61K31/47 ,  A61P25/28 ,  C07D209/96 ,  C07D217/20

Abstract: The invention relates to acutumine and compounds thereof and also to compounds of formula (I): wherein R 1 and R 2 each represent hydrogen or together form an additional bond, R 3 represents hydrogen or alkoxy, R 5 represents hydrogen or chlorine, R 6 represents hydrogen or alkyl, alkylcarbonyl or aroyl, R 7 and R 10 each represent alkoxy, R 10 represents alkoxy, R 4 , R 8 , R 9 , R 11 , R 12 , R 13 and R 14 are as defined in the description. and medicinal products containing the same which are useful in treating deficiencies of memory.

公开(公告)号：ZA200410280B

公开(公告)日：2006-07-26

申请号：ZA200410280

申请日：2004-12-21

Applicant: SHANGHAI INST MATERIA MEDICA ,  SERVIER LAB

Inventor： QIN GUO-WEI ,  TANG XI-CAN ,  LESTAGE PIERRE ,  CAIGNARD DANIEL-HENRI ,  RENARD PIERRE

IPC: A61K20060101 ,  A61K31/47 ,  A61P20060101 ,  A61P25/28 ,  C07D20060101 ,  C07D209/96 ,  C07D217/20

Abstract: The invention relates to acutumine and compounds thereof and also to compounds of formula (I): wherein R 1 and R 2 each represent hydrogen or together form an additional bond, R 3 represents hydrogen or alkoxy, R 5 represents hydrogen or chlorine, R 6 represents hydrogen or alkyl, alkylcarbonyl or aroyl, R 7 and R 10 each represent alkoxy, R 10 represents alkoxy, R 4 , R 8 , R 9 , R 11 , R 12 , R 13 and R 14 are as defined in the description. and medicinal products containing the same which are useful in treating deficiencies of memory.

公开(公告)号：BR0312444A

公开(公告)日：2005-05-10

申请号：BR0312444

申请日：2003-06-16

Applicant: SHANGHAI INST MATERIA MEDICA ,  SERVIER LAB

Inventor： QIN GUO-WEI ,  TANG XI-CAN ,  LESTAGE PIERRE ,  CAIGNARD DANIEL HENRI ,  RENARD PIERRE

IPC: A61K31/47 ,  A61P25/28 ,  C07D209/96 ,  C07D217/20

Abstract: The invention relates to acutumine and compounds thereof and also to compounds of formula (I): wherein R 1 and R 2 each represent hydrogen or together form an additional bond, R 3 represents hydrogen or alkoxy, R 5 represents hydrogen or chlorine, R 6 represents hydrogen or alkyl, alkylcarbonyl or aroyl, R 7 and R 10 each represent alkoxy, R 10 represents alkoxy, R 4 , R 8 , R 9 , R 11 , R 12 , R 13 and R 14 are as defined in the description. and medicinal products containing the same which are useful in treating deficiencies of memory.

公开(公告)号：CA2491214A1

公开(公告)日：2003-12-31

申请号：CA2491214

申请日：2003-06-16

Applicant: SERVIER LAB ,  SHANGHAI INST MEDICA

Inventor： RENARD PIERRE ,  QIN GUO-WEI ,  TANG XI-CAN ,  LESTAGE PIERRE ,  CAIGNARD DANIEL-HENRI

IPC: A61K31/47 ,  A61P25/28 ,  C07D209/96 ,  C07D217/20

Abstract: The invention relates to acutumine and compounds thereof and also to compoun ds of formula (I) wherein Rl and R2 each represent a hydrogen atom or together form an additional bond, R3 represents a hydrogen atom or an alkoxy group, R 3 represents a hydrogen or chlorine atom, R6 represents a hydrogen atom or an alkyl, alkylcarbonyl or amyl group, R7 and R10 each represent an alkoxy grou p, RIO represents an alkoxy group, R4, R8, R9, R11, R12, R13 and R14 are as defined in the description.

公开(公告)号：EA007229B1

公开(公告)日：2006-08-25

申请号：EA200500081

申请日：2003-06-16

Applicant: SHANGHAI INST MATERIA MEDICA ,  SERVIER LAB

Inventor： QIN GUO-WEI ,  TANG XI-CAN ,  LESTAGE PIERRE ,  CAIGNARD DANIEL-HENRI ,  RENARD PIERRE

IPC: C07D217/20 ,  A61K31/47 ,  A61P25/28 ,  C07D209/96

Abstract: Изобретениеотноситсяк акутуминуи егосоединениям, атакжек соединениямформулы (I)вкоторых Rи R, каждыйпредставляетсобойатомводородаиливместеобразуютдополнительнуюсвязь, Rпредставляетсобойатомводородаилиалкоксигруппу, Rпредставляетсобойатомводородаилихлора, Rпредставляетсобойатомводородаилиалкильную, алкилкарбонильнуюилиароильнуюгруппу, Rи R, каждыйпредставляетсобойалкоксигруппу, Rпредставляетсобойалкоксигруппу, R, R, R, R, R, Rи Rимеютзначения, указанныев описании. Лекарственныесредства.

公开(公告)号：BR0316609A

公开(公告)日：2005-10-11

申请号：BR0316609

申请日：2003-11-26

Applicant: SHANGHAI INST MATERIA MEDICA ,  SERVIER LAB

Inventor： QIN GUO-WEI ,  TANG XI-CAN ,  WANG RUI ,  ZHOU TIAN-XI ,  LESTAGE PIERRE ,  CAIGNARD DANIEL HENRI ,  RENARD PIERRE

IPC: C07D221/28 ,  C07D489/00 ,  A61K31/485

Abstract: The invention relates to sinomenine and compounds thereof and also to compounds of formula (I): wherein R 1 represents alkyl, R 2 represents hydrogen or alkylcarbonyl, haloalkylcarbonyl or arylcarbonyl, Y represents a group R 3 , R 4 , R' 4 , R 5 , R' 5 and R 6 are as defined in the description, and X represents halogen and medicinal products containing the same which are useful in treating mnemocognitive disorders.

公开(公告)号：MA27573A1

公开(公告)日：2005-10-03

申请号：MA28362

申请日：2005-06-27

Applicant: SERVIER LAB ,  SHANGHAI INST MATERIA MEDICA

Inventor： QIN GUO-WEI ,  TANG XI-CAN ,  WANG RUI ,  ZHOU TIAN-XI ,  LESTAGE PIERRE ,  CAIGNARD DANIEL-HENRI ,  RENARD PIERRE

IPC: C07D221/28 ,  C07D489/00 ,  A61K31/485

Abstract: SINOMENINE ET DERIVES DE SINOMENINE , SYNTHESE ET UTILISATION L'invention concerne la sinoménine et ses dérivés, ainsi que les composés de formule (I) dans laquelle - R1 représente un groupement alkyle, - R2 représente un atome d'hydrogène ou un groupement alkylcarbonyle, haloalkylcarbonyle ou arylcarbonyle - Y represent un groupe R3 ,R4, R'4, R5, R'5 et R6 sont tels que définis dans la description, - et X représente un atome d'halogène. Médicaments.

公开(公告)号：MA27264A1

公开(公告)日：2005-03-01

申请号：MA28062

申请日：2005-01-24

Applicant: SHANGHAI INST MATERIA MEDICA ,  SERVIER LAB

Inventor： QIN GUO-WEI ,  TANG XI-CAN ,  LESTAGE PIERRE ,  CAIGNARD DANIEL-HENRI ,  RENARD PIERRE

IPC: A61K31/47 ,  A61P25/28 ,  C07D209/96 ,  C07D217/20

Abstract: ACUTUMINE ET DERIVES D'ACUTUMINE, SYNTHESE ET UTILISATION L'invention concerne l'acutumine et ses dérivés, ainsi que les composés de formule (I) : dans laquelle „ R1 et R2 représentent un atome d'hydrogène ou forment ensemble une liaison supplémentaire, „ R3 représente un atome d'hydrogène ou un groupement alkoxy, „ R5 représente un atome d'hydrogène ou de chlore, „ R6 représente un atome d'hydrogène ou un groupement alkyle, alkylecarbonyle ou aroyle, „ R7 et R10 représentent un groupement alkoxy, „ R10 représente un groupement alkoxy, „ R4, R8, R9, R11, R12, R13 et R14 sont tels que définis dans la description. Médicaments