公开(公告)号：WO2009066035A3

公开(公告)日：2009-08-27

申请号：PCT/FR2008001261

申请日：2008-09-10

Applicant: SERVIER LAB ,  VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  VALLEZ MARIE-ODILE ,  FRATACCI MARIE-DOMINIQUE ,  LREOND LAURENCE ,  LAVIELLE GILBERT

Inventor： VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  VALLEZ MARIE-ODILE ,  FRATACCI MARIE-DOMINIQUE ,  LREOND LAURENCE ,  LAVIELLE GILBERT

IPC: C07C311/20 ,  A61K31/18 ,  A61K31/404 ,  C07D209/42

CPC classification number: C07D209/42 ,  A61K31/18 ,  A61K31/404 ,  A61K45/06 ,  C07C311/20 ,  A61K2300/00

Abstract: Combination of an anti-atherothrombotic and an angiotensin-converting enzyme inhibitor (ACEI), and also pharmaceutical compositions containing same. Medicaments

Abstract translation: 抗动脉粥样硬化血栓形成和血管紧张素转化酶抑制剂（ACEI）的组合，以及含有其的药物组合物。 药品

公开(公告)号：HRP20190193T1

公开(公告)日：2019-04-05

申请号：HRP20190193

申请日：2019-01-30

Applicant: SERVIER LAB

Inventor： GLOANEC PHILIPPE ,  SCHAFFNER ARNAUD-PIERRE ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  MENNECIER PHILIPPE ,  VALLEZ MARIE-ODILE

IPC: A61K31/66 ,  A61K9/00 ,  A61K31/675 ,  A61K45/06 ,  C07F9/6568 ,  C07F9/6584

公开(公告)号：MD3271368T2

公开(公告)日：2019-03-31

申请号：MDE20180097

申请日：2017-01-13

Applicant: SERVIER LAB

Inventor： GLOANEC PHILIPPE ,  SCHAFFNER ARNAUD-PIERRE ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  MENNECIER PHILIPPE ,  VALLEZ MARIE-ODILE

IPC: A61K31/66 ,  A61K9/00 ,  A61K31/675 ,  A61K45/06 ,  C07F9/6568 ,  C07F9/6584

Abstract: Compuşii cu formula (I) în care: Ak1 reprezintă o catenă alchil, X reprezintă - (CH2) m-, -CH (R) -, -N (R) R, -CH2- sau -CH2-N (R) -CH2-, m şi R sunt definiţi ca în descriere, R1 şi R2 reprezintă fiecare H atunci când X reprezintă - (CH2) m-, -CH (R) -N (R) - sau -N (R) -CH2- sau într-adevăr împreună formează o legătură atunci când X reprezintă -CH2-N (R) -CH2-, R3 reprezintă NH2, -NH2, Cy-Ak3-NH2 sau piperidin-4-il, Cy şi Ak3 sunt definiţi ca în descriere, R4 şi R5, identici sau diferiţi, reprezintă fiecare H sau F, izomerii optici ai acestuia şi acidul acceptabil farmaceutic săruri de adiţie ale acestora. Invenţia se referă de asemenea la medicamente care conţin aceleaşi substanţe.

公开(公告)号：PH12018501373A1

公开(公告)日：2019-02-27

申请号：PH12018501373

申请日：2018-06-26

Applicant: SERVIER LAB

Inventor： GLOANEC PHILIPPE ,  SCHAFFNER ARNAUD-PIERRE ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  MENNECIER PHILIPPE ,  VALLEZ MARIE-ODILE

IPC: A61K31/675 ,  A61P9/00 ,  C07F9/6584

Abstract: Compounds of formula (I) in which: Ak1 represents an alkyl chain, X represents -(CH2)m-, -CH(R)-, -N(R)-,-CH2-N(R)-, -N(R)-CH2- or -CH2-N(R)-CH2-, m and R are as defined in the description, R1 and R2 each represent H when X represents -(CH2)m-, -CH(R)-, -N(R)-, -CH2-N(R)- or -N(R)-CH2-, or indeed together form a bond when X represents -CH2-N(R)-CH2-, R3 represents NH2, Cy-NH2, Cy-Ak3-NH2 or piperidin-4-yle, Cy and Ak3 are as defined in the description, R4 and R5, identical or different, each represent H or F, the optical isomers of same, and the pharmaceutically acceptable acid addition salts thereof. The invention also relates to drugs containing same.

公开(公告)号：SG11201805757WA

公开(公告)日：2018-08-30

申请号：SG11201805757W

申请日：2017-01-13

Applicant: SERVIER LAB

Inventor： GLOANEC PHILIPPE ,  SCHAFFNER ARNAUD-PIERRE ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  MENNECIER PHILIPPE ,  VALLEZ MARIE-ODILE

IPC: C07F9/6584 ,  A61K31/675 ,  A61P9/00

Abstract: Medicinal products containing the same which are useful in treating conditions requiring a TAFIa inhibitor.

公开(公告)号：CA3011184A1

公开(公告)日：2017-07-20

申请号：CA3011184

申请日：2017-01-13

Applicant: SERVIER LAB

Inventor： GLOANEC PHILIPPE ,  SCHAFFNER ARNAUD-PIERRE ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  MENNECIER PHILIPPE ,  VALLEZ MARIE-ODILE

IPC: C07F9/6584 ,  A61K31/675 ,  A61P9/00

Abstract: Composés de formule (I) dans laquelle : Ak1 représente une chaîne alkyle, X représente -(CH2)m-, -CH(R)-, -N(R)-,-CH2-N(R)-, N(R)-CH2-ou -CH2-N(R)-CH2-, m et R sont tels que définis dans la description, R1 et R2 représentent chacun H lorsque X représente -(CH2)m-, -CH(R)-, -N(R)-, -CH2-N(R)- ou N(R)-CH2-, ou bien forment ensemble une liaison lorsque X représente -CH2-N(R)-CH2-, R3 représente NH2, Cy-NH2, Cy-Ak3-NH2 ou pipéridin-4-yle, Cy et Ak3 sont tels que définis dans la description, R4 et R5, identiques ou différents, représentent chacun H ou F, leurs isomères optiques, ainsi que leurs sels d'addition à un acide pharmaceutiquement acceptable. Médicaments.

公开(公告)号：CY1107157T1

公开(公告)日：2012-10-24

申请号：CY081100096

申请日：2008-01-28

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  GLOANEC PHILLIPPE ,  PARMENTIER JEAN GILLES ,  BENOIST ALAIN ,  RUPIN ALAIN ,  VALLEZ MARIE-ODILE ,  VERBEUREN TONY

IPC: C07D487/04 ,  A61K31/498 ,  A61K31/519 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P43/00

Abstract: Ένωσητουτύπου (Ι):

公开(公告)号：BRPI1001935A2

公开(公告)日：2012-03-06

申请号：BRPI1001935

申请日：2010-06-24

Applicant: SERVIER LAB ,  INST NAT SCIENCES APPLIQ ,  CENTRE NAT RECH SCIENT ,  UNIV ROUEN

Inventor： GLOANEC PHILIPPE ,  DE NANTEUIL GUILLAUME ,  PARMENTIER JEAN-GILLES ,  GUILLOUZIC ANNE-FRANCOISE ,  VERBEUREN TONY ,  RUPIN ALAIN ,  MENNECIER PHILIPPE ,  VALLEZ MARIE-ODILE ,  QUIRION JEAN-CHARLES ,  JUBAULT PHILIPPE ,  BOYER NICOLAS

IPC: C07C13/10 ,  A61P7/02

Abstract: 2-Mercaptocyclopentanecarboxylic acid compounds (I) and their optical isomers and acid addition salts are new. 2-Mercaptocyclopentanecarboxylic acid compounds of formula (I) and their optical isomers and acid addition salts are new. R 1 : H or COR 4; R 4 : 1-6C alkyl or aryl or cyclopentane carboxylic acid group of formula (II); R 2 : NR 5R 6; R 5, R 6 : H, 1-6C alkyl, group, a nitrogen-containing heterocyclic group, aryl or heteroaryl; R 3 : H or 1-6C alkyl; m : 1-6; and n : 0-2. An independent claim is included for a composition comprising (I) in combination with one or more inert, non-toxic, excipients or carriers. [Image] [Image] ACTIVITY : Cardiant; Antianginal; Antiinflammatory; Vasotropic; Thrombolytic; Cerebroprotective; Vulnerary; Nootropic. MECHANISM OF ACTION : Thrombin-activatable fibrinolysis inhibitor (TAFI). (I) were tested for their TAF inhibitory activity using purified human TAFI. The results showed that the IC 5 0value of (I) was 6.7+- 0.6 nM.

公开(公告)号：ECSP10010292A

公开(公告)日：2011-06-30

申请号：ECSP10010292

申请日：2010-06-21

Applicant: SERVIER LAB ,  INST NAIONAL DES SCIENCES APPLIQUEES DE ROUEN L ,  CENTRE NAT RECH SCIENT ,  UNIV ROUEN L

Inventor： VERBEUREN TONY ,  RUPIN ALAIN ,  DE NANTEUIL GUILLAUME ,  GLOANEC PHILIPPE ,  VALLEZ MARIE-ODILE ,  PARMENTIER JEAN-GILLES ,  GUILLOUZIC ANNE FRANCOISE ,  MENNECIER PHILIPPE ,  QUIRION JEAN CHARLES ,  JUBAULT PHILIPPE ,  BOYER NICOLAS

IPC: A61K31/09 ,  C07D207/08 ,  C07D207/12

Abstract: NUEVOS DERIVADOS DE ÁCIDO 2-MERCAPTOCICLOPENTANOCARBOXÍLICO, SU PROCEDIMIENTO DE PREPARACIÓN Y LAS COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN

公开(公告)号：UY32702A

公开(公告)日：2010-12-31

申请号：UY32702

申请日：2010-06-10

Applicant: SERVIER LAB ,  INST NAT SCIENCES APPLIQ ,  CENTRE NAT RECH SCIENT ,  UNIIVERSITE DE ROUEN L

Inventor： TONY VERBEUREN ,  ALAIN RUPIN ,  NANTEUIL GUILLAUME DE ,  PHILIPPE GLOANEC ,  PARMENTIER JEAN-GILLES ,  GUILLOUZIC ANNE-FRANCOISE ,  PHILIPPE MENNECIER ,  VALLEZ MARIE-ODILE ,  QUIRION JEAN-CHARLES ,  PHILIPPE JUBAULT ,  NICOLAS BOYER

IPC: A61K31/19 ,  A61K31/44 ,  A61K31/445 ,  A61P7/04 ,  C07C321/22 ,  C07D211/08 ,  C07D213/24

Abstract: Compuestos de fórmula (I): en la que: R1 representa un átomo de hidrógeno o un grupo de fórmula COR4, o bien R1 representa un grupo de fórmula (A): R2 representa un grupo de fórmula NR5R6, o bien R2 representa un grupo heterocíclico nitrogenado, arilo o heteroarilo, R3 representa un átomo de hidrógeno o un grupo alquilo, m representa un número entero comprendido entre 1 y 6, n representa 0, 1 ó 2, sus isómeros ópticos, así como sus sales de adición a un ácido farmacéuticamente aceptable. Medicamentos.