公开(公告)号：WO2009066035A3

公开(公告)日：2009-08-27

申请号：PCT/FR2008001261

申请日：2008-09-10

Applicant: SERVIER LAB ,  VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  VALLEZ MARIE-ODILE ,  FRATACCI MARIE-DOMINIQUE ,  LREOND LAURENCE ,  LAVIELLE GILBERT

Inventor： VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  VALLEZ MARIE-ODILE ,  FRATACCI MARIE-DOMINIQUE ,  LREOND LAURENCE ,  LAVIELLE GILBERT

IPC: C07C311/20 ,  A61K31/18 ,  A61K31/404 ,  C07D209/42

CPC classification number: C07D209/42 ,  A61K31/18 ,  A61K31/404 ,  A61K45/06 ,  C07C311/20 ,  A61K2300/00

Abstract: Combination of an anti-atherothrombotic and an angiotensin-converting enzyme inhibitor (ACEI), and also pharmaceutical compositions containing same. Medicaments

Abstract translation: 抗动脉粥样硬化血栓形成和血管紧张素转化酶抑制剂（ACEI）的组合，以及含有其的药物组合物。 药品

公开(公告)号：HRP20190193T1

公开(公告)日：2019-04-05

申请号：HRP20190193

申请日：2019-01-30

Applicant: SERVIER LAB

Inventor： GLOANEC PHILIPPE ,  SCHAFFNER ARNAUD-PIERRE ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  MENNECIER PHILIPPE ,  VALLEZ MARIE-ODILE

IPC: A61K31/66 ,  A61K9/00 ,  A61K31/675 ,  A61K45/06 ,  C07F9/6568 ,  C07F9/6584

公开(公告)号：MD3271368T2

公开(公告)日：2019-03-31

申请号：MDE20180097

申请日：2017-01-13

Applicant: SERVIER LAB

Inventor： GLOANEC PHILIPPE ,  SCHAFFNER ARNAUD-PIERRE ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  MENNECIER PHILIPPE ,  VALLEZ MARIE-ODILE

IPC: A61K31/66 ,  A61K9/00 ,  A61K31/675 ,  A61K45/06 ,  C07F9/6568 ,  C07F9/6584

Abstract: Compuşii cu formula (I) în care: Ak1 reprezintă o catenă alchil, X reprezintă - (CH2) m-, -CH (R) -, -N (R) R, -CH2- sau -CH2-N (R) -CH2-, m şi R sunt definiţi ca în descriere, R1 şi R2 reprezintă fiecare H atunci când X reprezintă - (CH2) m-, -CH (R) -N (R) - sau -N (R) -CH2- sau într-adevăr împreună formează o legătură atunci când X reprezintă -CH2-N (R) -CH2-, R3 reprezintă NH2, -NH2, Cy-Ak3-NH2 sau piperidin-4-il, Cy şi Ak3 sunt definiţi ca în descriere, R4 şi R5, identici sau diferiţi, reprezintă fiecare H sau F, izomerii optici ai acestuia şi acidul acceptabil farmaceutic săruri de adiţie ale acestora. Invenţia se referă de asemenea la medicamente care conţin aceleaşi substanţe.

公开(公告)号：PH12018501373A1

公开(公告)日：2019-02-27

申请号：PH12018501373

申请日：2018-06-26

Applicant: SERVIER LAB

Inventor： GLOANEC PHILIPPE ,  SCHAFFNER ARNAUD-PIERRE ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  MENNECIER PHILIPPE ,  VALLEZ MARIE-ODILE

IPC: A61K31/675 ,  A61P9/00 ,  C07F9/6584

Abstract: Compounds of formula (I) in which: Ak1 represents an alkyl chain, X represents -(CH2)m-, -CH(R)-, -N(R)-,-CH2-N(R)-, -N(R)-CH2- or -CH2-N(R)-CH2-, m and R are as defined in the description, R1 and R2 each represent H when X represents -(CH2)m-, -CH(R)-, -N(R)-, -CH2-N(R)- or -N(R)-CH2-, or indeed together form a bond when X represents -CH2-N(R)-CH2-, R3 represents NH2, Cy-NH2, Cy-Ak3-NH2 or piperidin-4-yle, Cy and Ak3 are as defined in the description, R4 and R5, identical or different, each represent H or F, the optical isomers of same, and the pharmaceutically acceptable acid addition salts thereof. The invention also relates to drugs containing same.

公开(公告)号：SG11201805757WA

公开(公告)日：2018-08-30

申请号：SG11201805757W

申请日：2017-01-13

Applicant: SERVIER LAB

Inventor： GLOANEC PHILIPPE ,  SCHAFFNER ARNAUD-PIERRE ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  MENNECIER PHILIPPE ,  VALLEZ MARIE-ODILE

IPC: C07F9/6584 ,  A61K31/675 ,  A61P9/00

Abstract: Medicinal products containing the same which are useful in treating conditions requiring a TAFIa inhibitor.

公开(公告)号：CA3011184A1

公开(公告)日：2017-07-20

申请号：CA3011184

申请日：2017-01-13

Applicant: SERVIER LAB

Inventor： GLOANEC PHILIPPE ,  SCHAFFNER ARNAUD-PIERRE ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  MENNECIER PHILIPPE ,  VALLEZ MARIE-ODILE

IPC: C07F9/6584 ,  A61K31/675 ,  A61P9/00

Abstract: Composés de formule (I) dans laquelle : Ak1 représente une chaîne alkyle, X représente -(CH2)m-, -CH(R)-, -N(R)-,-CH2-N(R)-, N(R)-CH2-ou -CH2-N(R)-CH2-, m et R sont tels que définis dans la description, R1 et R2 représentent chacun H lorsque X représente -(CH2)m-, -CH(R)-, -N(R)-, -CH2-N(R)- ou N(R)-CH2-, ou bien forment ensemble une liaison lorsque X représente -CH2-N(R)-CH2-, R3 représente NH2, Cy-NH2, Cy-Ak3-NH2 ou pipéridin-4-yle, Cy et Ak3 sont tels que définis dans la description, R4 et R5, identiques ou différents, représentent chacun H ou F, leurs isomères optiques, ainsi que leurs sels d'addition à un acide pharmaceutiquement acceptable. Médicaments.

公开(公告)号：AU2009201068B2

公开(公告)日：2012-11-22

申请号：AU2009201068

申请日：2009-03-17

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  PAYSANT JEROME ,  LEFOULON FRANCOIS

IPC: C07D311/30 ,  A61K31/352 ,  A61P7/02 ,  A61P9/10 ,  C07D407/02 ,  C07D407/12 ,  C07D407/14

Abstract: NEW DIOSMETIN COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Abstract The invention relates to compounds of formula (1): HC OR3 0 CH 2 wherein R1, R2 and R3, which may be the same or different, each represent a hydrogen atom or the group of formula (A): 0 (A) The invention also relates to pharmaceutical compositions comprising a compound of 10 formula (1) and methods of treatment comprising administering compounds of formula (1) or a pharmaceutical composition thereof.

公开(公告)号：ME00680B

公开(公告)日：2011-12-20

申请号：MEP10909

申请日：2009-03-31

Applicant: SERVIER LAB

Inventor： RUPIN ALAIN ,  WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANÇOISE ,  VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  PAYSANT JÉRÔME ,  LEFOULON FRANÇOIS

IPC: C07D311/30 ,  A61K31/35 ,  C07D407/12 ,  C07D407/14 ,  C07H15/26

Abstract: Jedinjenja formule (I): Gde R 1 R 2 i R 3 , koji mogu biti isti ili različiti, pojedinačno predstavljaju atom vodonika ili grupu formule (A): Lekovi.

公开(公告)号：PL2107055T3

公开(公告)日：2011-06-30

申请号：PL09290237

申请日：2009-03-31

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANÇOISE ,  VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  PAYSANT JÉRÔME ,  LEFOULON FRANÇOIS

IPC: A61K31/352 ,  C07D311/30 ,  A61K31/7012 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  C07D407/12 ,  C07H15/26

公开(公告)号：NZ560749A

公开(公告)日：2010-11-26

申请号：NZ56074906

申请日：2006-02-28

Applicant: SERVIER LAB

Inventor： VERBEUREN TONY ,  RUPIN ALAIN ,  SANSILVESTRI-MOREL PATRICIA ,  VALLEZ MARIE-ODILE ,  BOUSSARD MARIE-FRANCOISE ,  WIERZBICKI MICHEL

IPC: A61K31/352 ,  A61P7/02

Abstract: Disclosed is the use of diosmetin compounds of formula (I) wherein the substituents are disclosed within the specification in the manufacture of a medicament for the prevention and/or treatment of thrombotic pathologies.