公开(公告)号：DE1933846A1

公开(公告)日：1970-01-15

申请号：DE1933846

申请日：1969-07-03

Applicant: SHIMADZU CORP

Inventor： KUBODERA TOSHIYA ,  HARA TASUKU ,  MAKABE HIDEKI

IPC: B01J14/00 ,  B01J19/00 ,  C07K1/04 ,  C40B40/10 ,  C40B60/14 ,  C07C103/52

Abstract: An apparatus for synthesis of peptides or the like organic compounds, in which transfer of the selected reagents into and out of a reaction vessel is conducted by utilizing vacuum and a pressurized inert gas under control of various valves. No liquid pumps are required. The sequential operation of the valves may be automatically controlled by a programmer.

公开(公告)号：US3647390A

公开(公告)日：1972-03-07

申请号：US3647390D

申请日：1969-07-03

Applicant: SHIMADZU CORP

Inventor： KUBODERA TOSHIYA ,  HARA TASUKU ,  MAKABE HIDEKI

IPC: B01J14/00 ,  B01J19/00 ,  C07K1/04 ,  C40B40/10 ,  C40B60/14 ,  C07C103/52

CPC classification number: C07K1/045 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00416 ,  B01J2219/00418 ,  B01J2219/00423 ,  B01J2219/005 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00686 ,  B01J2219/00695 ,  B01J2219/00725 ,  C40B40/10 ,  C40B60/14

Abstract: An apparatus for synthesis of peptides or the like organic compounds, in which transfer of the selected reagents into and out of a reaction vessel is conducted by utilizing vacuum and a pressurized inert gas under control of various valves. No liquid pumps are required. The sequential operation of the valves may be automatically controlled by a programmer.

Abstract translation: 用于合成肽等有机化合物的装置，其中所选择的试剂进出反应容器是通过在各种阀控制下利用真空和加压惰性气体来进行的。 不需要液体泵。 阀的顺序操作可以由程序员自动控制。

公开(公告)号：JPH01270659A

公开(公告)日：1989-10-27

申请号：JP10100388

申请日：1988-04-22

Applicant: SHIMADZU CORP

Inventor： KUBODERA TOSHIYA ,  ITOI HIROTO

IPC: G01N27/62 ,  G01N30/72 ,  H01J49/06

Abstract: PURPOSE:To lower a background level and to obtain high sensitivity, by removing ions of a carrier gas by a mass filter. CONSTITUTION:An outer case W of a detector is connected to a vacuum pump, while a column C of a gas chromatograph G is connected to an ionizing chamber I inside the outer case W. When a voltage is impressed between a filament 2 and the ionizing chamber I, electrons released from the filament 2 are accelerated and proceeds into the ionizing chamber I through a small hole (h), and it collides with molecules of a sample gas flowing out of the column C and is ionized. Ions of the sample gas are led out by an ion lead-out electrode 3 and accelerated, and they are turned into an ion beam by an ion lens 4 and made to enter a magnetic field 5 for a mass filter. On the occasion, ions of He, which is a carrier gas, are turned at an angle of 180 deg. along a semi-circular track and emitted from the magnetic field, while ions having a larger mass than He are emitted from a back 52 and made to enter an ion detector 6 to be detected, and an output of the detector 6 is sent to a data processing circuit through a preamplifier 7.

公开(公告)号：JPS62261059A

公开(公告)日：1987-11-13

申请号：JP10561286

申请日：1986-05-07

Applicant: SHIMADZU CORP

Inventor： WADA NAOKI ,  KUBODERA TOSHIYA

IPC: G01N30/54

Abstract: PURPOSE:To achieve a higher reproducibility of retention time, by providing a metal member made of a ferromagnetic material for retaining a column with an induction coil which is energized by a current enough to heat at a Curie temperature thereof to eliminate variations in the temperature adjusting accuracy. CONSTITUTION:A capillary column 2 is retained on an internal surface of metal plates 1a and 1b which are mainly composed of a ferromagnetic material such as iron, nickel and cobalt and are adapted to obtain a desired Curie temperature varying the composition ratio or the like with other metals while induction coils 4a and 4b to be energized by AC from a power source 5 are provided on the external surface thereof so as to heat the metal plates 1a and 1b at a Curie temperature thereof. Then, as an AC is supplied to coil 4a and 4b, a magnetic flux is applied to the metal plates 1a and 1b, which are heated and elevated in the temperature by a heat generated by an eddy current loss and a ferromagnetic hysteresis loop loss. When a Curie temperature is reached, the metal plates 1a and 1b lose a ferromagnetic property to become paramagnetic and the heating due to the eddy current loss and the paramagnetic hysteresis loop loss maintains the temperature. Thus, the column 2 is kept at the Curie temperature of the metal plates 1a and 1b.

公开(公告)号：JPH0382949A

公开(公告)日：1991-04-08

申请号：JP21984689

申请日：1989-08-25

Applicant: TSUDA TAKAO ,  SHIMADZU CORP

Inventor： TSUDA TAKAO ,  KUBODERA TOSHIYA ,  NAGATO KENKICHI

IPC: G01N27/62 ,  G01N30/72 ,  H01J49/04

Abstract: PURPOSE:To prevent the exit of a column from being clogged thereby to obtain a stable mass spectrum by dispersing very fine particles into a sample liquid introduced into an ion source from said exit of the micro column. CONSTITUTION:Very fine particles 4 which do not affect the separation of a sample liquid in a micro column 10 are dispersed in the sample liquid introduced into an ion source from the exit of the micro column. In other words, the very fine particles 4 are dispersed in an eluent 2 of the liquid chromatograph or into a route from the liquid chromatograph to the coupling part of the liquid chromatograph with a mass spectrometer. It is desirable for the very fine particles 4 to have the particle size of about 10mmu. For example, Aerosil, TiO2 etc. are employed. Accordingly, the sample liquid can be held at the surface of the very fine particles 4, and stably and effectively introduced to the ion source. Moreover, an interface 5 between a liquid phase part 3 and a gas phase at an exit of the column is stabilized. Further, since the very fine particles 4 work to clean the end of the column, it is prevented that the end of the column is clogged.

公开(公告)号：JPH01161206A

公开(公告)日：1989-06-23

申请号：JP32089187

申请日：1987-12-17

Applicant: SHIMADZU CORP

Inventor： TAKADA MICHINOSUKE ,  KUBODERA TOSHIYA

IPC: G02B6/24 ,  G02B6/42

Abstract: PURPOSE:To improve the remote control of a laser device by including a signal line for controlling the operation of the laser device in a light guide cable in addition to a light guide for guiding laser beams and connecting both the light guide and signal line to a connecting connector. CONSTITUTION:A large laser device or an exciting laser device 4 is arranged on another room B and the laser device in the other room is connected to a laboratory or a medical room A through the connecting connector 8, 12-1, 12-2. When the light guide cables 10-1, 10-2 for the laboratory or the medical room A are connected to the connectors 12-1, 12-2, the light guides 16, 26 are connected, the signal lines are also connected, the laser device arranged in the other room is turned on and controlled so that its output intensity can be set up to an optimum value. Consequently, the operability of the laser device arranged on the other room can be improved.

公开(公告)号：JPS63259443A

公开(公告)日：1988-10-26

申请号：JP9474387

申请日：1987-04-16

Applicant: SHIMADZU CORP

Inventor： TAKADA MICHINOSUKE ,  KUBODERA TOSHIYA

IPC: G01N21/13 ,  G01N21/25 ,  G01N21/75

Abstract: PURPOSE:To enable the measuring of samples on optimum conditions, by setting optimum measuring time interval for the samples for measuring data of a plurality of samples obtained in the initial stage at a relatively short time interval to repeat the measurement at this time interval. CONSTITUTION:Samples of a plurality of sample cells 2a, 2b,... set in a cell 2 are switched with a driver 4 controlled by a control section 12 and automatically inserted into an optical path to measure absorbance thereof. The achieve this function, a memory 14 of the control section 12 stores a data measured, a change rate calculating means 16 calculates the change rate of the respective samples from those at the initial stage among measuring data of the memory 14 and an initial switching interval setting means 20 set a short sample switching interval at the initial stage. Moreover, a switching interval control section 18 of the control section 12 controls the driver 4 so that the samples quick in changes are switched at a short time interval, and those slow in changes at a long time interval according to a setting means 20 at the initial stage and according to a calculated value of a calculating means 16 after the calculation of the change rate.

公开(公告)号：JPS62168332A

公开(公告)日：1987-07-24

申请号：JP28707985

申请日：1985-12-20

Applicant: SHIMADZU CORP

Inventor： KUBODERA TOSHIYA ,  TAKEDA TAKEHIRO

IPC: G01N27/62 ,  H01J49/06 ,  H01J49/32

Abstract: PURPOSE:To enlarge analytic information with carrying out only simple addition, by introducing reaction gas for a reaction chamber, selecting the ions of a specified mass so as to inject them into the reaction chamber, and carrying out energy spectrometry for the generated ions. CONSTITUTION:Reaction gas is introduced for a reaction chamber A so as to be reacted upon the ions of a mass which is selected at a mass spectrometry portion. The ions generated from the reaction are passed through the reaction chamber A and are injected into the electric field E of an energy spectrometry portion, and the energy spectrum of the ions generated from the reaction can be obtained by sweeping the electric field E. This spectrum is converted to a mass spectrum. Namely, a cleavage pattern in case that the original ions are converted by the reaction gas is investigated, so that new analytic information whether the original ions are converted by hthe reaction gas or not, how the cleavage pattern changes by the conversion, or the like can be obtained.

公开(公告)号：JPS5981556A

公开(公告)日：1984-05-11

申请号：JP19158582

申请日：1982-10-30

Applicant: SHIMADZU CORP

Inventor： TAKEDA TSUNEZOU ,  KUBODERA TOSHIYA

IPC: G01N27/62 ,  G01N30/72 ,  G01N30/80 ,  G01N30/84

Abstract: PURPOSE:To eliminate a blockaded space by a branched pipe line and to remove obstacles due to the residence of sample components by using the side of a main gas pipe line as a valve. CONSTITUTION:In case of introducing the flowing components out of a gas chromatograph G to a mass spectrometer M, a silica capillary K is inserted into the inner part of a nozzle (n) and an opening hole (b) is shut by the capillary K itself. A gas flowed out of the gas chromatograph G is jetted from the nozzle (n) and introduced to an orifice (f). When the sample introduction to the mass spectrometer is stopped, the tip end of the capillary K is retreated to the left side of the opening hole (b). The flowing gas out of the gas chromatograph is flowed from the opening hole (b) to a waste gas chamber C and is sucked and removed by a pump P. The problem that a part of the sample components is diffused and introduced into the blockaded space and flowed gradually to the succeeding analyzing equipment can be solved.

公开(公告)号：JPS62168329A

公开(公告)日：1987-07-24

申请号：JP27726185

申请日：1985-12-09

Applicant: SHIMADZU CORP

Inventor： KUBODERA TOSHIYA ,  TAKEDA TAKEHIRO ,  SHIMIZU KIYOSHI

IPC: G01N27/62 ,  H01J49/32 ,  H01J49/46

Abstract: PURPOSE:To enable the mass spectrum of daughter ions generated form the parent ions of plural kinds to be measured simultaneously, by switching ion acceleration voltage at each cycle of energy scanning. CONSTITUTION:A magnetic field B for mass spectrometry is maintained constantly, electric field voltage which is applied to an electric field E is swept periodically so as to carry out energy scanning, and ion acceleration voltage is switched at each cycle of energy scanning. Thus, the switching of parent ions is carried out at a high speed, so that the mass spectrum of daughter ions from the parent ions of plural kinds can be measured substantially simultaneously.