公开(公告)号：CA2762612A1

公开(公告)日：2010-12-16

申请号：CA2762612

申请日：2010-06-07

Applicant: SINGULEX INC

Inventor： GOIX PHILIPPE J ,  PUSKAS ROBERT ,  TODD JOHN ,  LIVINGSTON RICHARD ,  HELD DOUGLAS ,  LE SARA

IPC: G01N33/68 ,  G01N33/52

Abstract: Cardiovascular disease, e.g., congestive heart failure, is often first diagnosed after the onset of clinical symptoms, eliminating potential for early intervention. The invention provides a multi-marker immunoassay, including cardiac pathology and vascular inflammation biomarkers, yielding a more sensitive assay for early detection of CHF in plasma. A panel consisting of cardiac pathology (cTnl, BNP) and vascular inflammation (IL-6, TNFa, IL- 17a) biomarkers provided a sensitivity of 94% for association with CHF.

公开(公告)号：AU2010259022B2

公开(公告)日：2016-05-12

申请号：AU2010259022

申请日：2010-06-07

Applicant: SINGULEX INC

Inventor： GOIX PHILIPPE J ,  PUSKAS ROBERT ,  TODD JOHN ,  LIVINGSTON RICHARD ,  HELD DOUGLAS ,  LE SARA

IPC: G01N33/68 ,  G01N33/52

Abstract: Cardiovascular disease, e.g., congestive heart failure, is often first diagnosed after the onset of clinical symptoms, eliminating potential for early intervention. The invention provides a multi-marker immunoassay, including cardiac pathology and vascular inflammation biomarkers, yielding a more sensitive assay for early detection of CHF in plasma. A panel consisting of cardiac pathology (cTnl, BNP) and vascular inflammation (IL-6, TNFα, IL- 17a) biomarkers provided a sensitivity of 94% for association with CHF.

公开(公告)号：EP2263085A4

公开(公告)日：2011-07-06

申请号：EP09731410

申请日：2009-03-04

Applicant: SINGULEX INC

Inventor： GOIX PHILIPPE J ,  PUSKAS ROBERT ,  TODD JOHN ,  LIVINGSTON RICHARD A ,  HELD DOUGLAS ,  LE SARA

IPC: G01N33/53

CPC classification number: G01N33/577 ,  A61B5/00 ,  A61B5/0402 ,  A61B5/412 ,  A61B5/415 ,  A61B5/418 ,  A61B5/7264 ,  A61B5/7275 ,  G01N21/6428 ,  G01N33/582 ,  G01N33/6863 ,  G01N33/6869 ,  G01N33/6872 ,  G01N33/6887 ,  G01N33/6896 ,  G01N33/74 ,  G01N33/92 ,  G01N2333/4712 ,  G01N2333/475 ,  Y02A90/26 ,  Y10T436/143333

Abstract: The present invention discloses methods for the detection and monitoring of a condition in a subject using highly sensitive detection of molecules. The invention provides a method for detecting or monitoring a condition in a subject, comprising detecting a first marker in a first sample from the subject and detecting a second marker, wherein the first marker comprises a biomarker, e.g., Cardiac Troponin-I (cTnI) or Vascular Endothelial Growth Factor (VEGF), and wherein the limit of detection of the first marker is less than about 10 pg/ml. The second marker can be a biomarker, physiological marker, a molecular marker or a genetic marker.

公开(公告)号：EP2440936A4

公开(公告)日：2013-03-13

申请号：EP10786631

申请日：2010-06-07

Applicant: SINGULEX INC

Inventor： GOIX PHILIPPE J ,  PUSKAS ROBERT ,  TODD JOHN ,  LIVINGSTON RICHARD ,  HELD DOUGLAS ,  LE SARA

IPC: G01N33/68 ,  G01N33/52

CPC classification number: G01N33/6869 ,  G01N33/6893 ,  G01N2333/32 ,  G01N2333/47 ,  G01N2333/4712 ,  G01N2333/525 ,  G01N2333/54 ,  G01N2333/5412 ,  G01N2333/58 ,  G01N2800/32 ,  G01N2800/325 ,  G01N2800/60