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公开(公告)号：WO2009126380A8
公开(公告)日：2010-11-04
申请号：PCT/US2009036086
申请日：2009-03-04
Applicant: SINGULEX INC , GOIX PHILIPPE J , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD A , HELD DOUGLAS , AGEE SARA
Inventor： GOIX PHILIPPE J , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD A , HELD DOUGLAS , AGEE SARA
IPC: G01N33/53
CPC classification number: G01N33/577 , A61B5/00 , A61B5/0402 , A61B5/412 , A61B5/415 , A61B5/418 , A61B5/7264 , A61B5/7275 , G01N21/6428 , G01N33/582 , G01N33/6863 , G01N33/6869 , G01N33/6872 , G01N33/6887 , G01N33/6896 , G01N33/74 , G01N33/92 , G01N2333/4712 , G01N2333/475 , Y02A90/26 , Y10T436/143333
Abstract: The present invention discloses methods for the detection and monitoring of a condition in a subject using highly sensitive detection of molecules. The invention provides a method for detecting or monitoring a condition in a subject, comprising detecting a first marker in a first sample from the subject and detecting a second marker, wherein the first marker comprises a biomarker, e.g., Cardiac Troponin-I (cTnl) or Vascular Endothelial Growth Factor (VEGF), and wherein the limit of detection of the first marker is less than about 10 pg/ml. The second marker can be a biomarker, physiological marker, a molecular marker or a genetic marker.
Abstract translation: 本发明公开了使用分子的高灵敏度检测来检测和监测受试者的状况的方法。 本发明提供了一种用于检测或监测受试者中的病症的方法，包括检测来自受试者的第一样品中的第一标志物并检测第二标志物，其中第一标记物包含生物标志物，例如心肌肌钙蛋白I（cTn1） 或血管内皮生长因子（VEGF），并且其中第一标记物的检测限小于约10pg / ml。 第二标记可以是生物标志物，生理学标记，分子标记或遗传标记。
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公开(公告)号：AU2008352940B2
公开(公告)日：2014-06-05
申请号：AU2008352940
申请日：2008-12-18
Applicant: SINGULEX INC
Inventor： LIVINGSTON RICHARD A
IPC: G01N35/00
Abstract: An analyzer for the detection of single molecules or molecular complexes uses electromagnetic radiation translated through the sample to detect the presence of absence of a molecule with zero carryover between samples.
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公开(公告)号：GB2470847A
公开(公告)日：2010-12-08
申请号：GB201013697
申请日：2008-12-19
Applicant: SINGULEX INC
Inventor： LIVINGSTON RICHARD A
Abstract: A single molecule analyzer uses electromagnetic radiation incident upon a sample container to form an interrogation space in the sample, wherein the container is translated such that the interrogation space is moveable through the sample to detect the presence or absence of a single molecule. A detector detects radiation emitted from molecules present in the interrogation space. A microscope objective in the beam path is used wherein the depth of field of the objective and the lateral extent of a radiation beam or the diameter of an aperture imaged to the objective focus together define the interrogation space. The analyzer is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.
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公开(公告)号：HK1152988A1
公开(公告)日：2012-03-16
申请号：HK11107106
申请日：2011-07-11
Applicant: SINGULEX INC
Inventor： LIVINGSTON RICHARD A
IPC: G01N20060101
Abstract: The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.
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公开(公告)号：CA2716522A1
公开(公告)日：2009-10-15
申请号：CA2716522
申请日：2009-03-04
Applicant: SINGULEX INC
Inventor： GOIX PHILIPPE J , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD A , HELD DOUGLAS , AGEE SARA
Abstract: The present invention discloses methods for the detection and monitoring of a condition in a subject using highly sensitive detection of molecules. The invention provides a method for detecting or monitoring a condition in a subject, comprising detecting a first marker in a first sample from the subject and detecting a second marker, wherein the first marker comprises a biomarker, e.g., Cardiac Troponin-I (cTnl) or Vascular Endothelial Growth Factor (VEGF), and wherein the limit of detection of the first marker is less than about 10 pg/ml. The second marker can be a biomarker, physiological marker, a molecular marker or a genetic marker.
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Patent Agency Ranking
公开(公告)号：CA2709217C
公开(公告)日：2021-01-05
申请号：CA2709217
申请日：2008-12-18
Applicant: SINGULEX INC
Inventor： LIVINGSTON RICHARD A
Abstract: An analyzer for the detection of single molecules or molecular complexes uses electromagnetic radiation translated through the sample to detect the presence of absence of a molecule with zero carryover between samples.
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公开(公告)号：GB2470847B
公开(公告)日：2012-06-27
申请号：GB201013697
申请日：2008-12-19
Applicant: SINGULEX INC
Inventor： LIVINGSTON RICHARD A
Abstract: The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.
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公开(公告)号：CA2709217A1
公开(公告)日：2009-09-24
申请号：CA2709217
申请日：2008-12-18
Applicant: SINGULEX INC
Inventor： LIVINGSTON RICHARD A
Abstract: An analyzer for the detection of single molecules or molecular complexes uses electromagnetic radiation translated through the sample to detect the presence of absence of a molecule with zero carryover between samples.
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公开(公告)号：AU2008352940A1
公开(公告)日：2009-09-24
申请号：AU2008352940
申请日：2008-12-18
Applicant: SINGULEX INC
Inventor： LIVINGSTON RICHARD A
IPC: G01N35/00
Abstract: The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.
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公开(公告)号：WO2009117033A3
公开(公告)日：2009-12-30
申请号：PCT/US2008087544
申请日：2008-12-18
Applicant: SINGULEX INC , LIVINGSTON RICHARD A
Inventor： LIVINGSTON RICHARD A
IPC: G01N35/00
CPC classification number: G01N21/6428 , B01L3/5085 , B01L2300/0654 , B01L2300/0829 , G01N15/14 , G01N15/1434 , G01N15/1456 , G01N15/1463 , G01N21/00 , G01N21/01 , G01N21/64 , G01N21/645 , G01N33/53 , G01N2015/0038 , G01N2015/1447 , G01N2015/1452 , G01N2201/02 , G01N2201/06113 , G01N2201/062 , G01N2201/0697
Abstract: An analyzer for the detection of single molecules or molecular complexes uses electromagnetic radiation translated through the sample to detect the presence of absence of a molecule with zero carryover between samples.
Abstract translation: 用于检测单分子或分子复合物的分析仪使用通过样品翻译的电磁辐射来检测样品之间没有携带残留的分子的存在。
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