公开(公告)号：AT401883T

公开(公告)日：2008-08-15

申请号：AT05850037

申请日：2005-12-06

Applicant: SOLVAY PHARM BV

Inventor： FEENSTRA ROELOF ,  STOIT AXEL ,  TERPSTRA JAN-WILLEM ,  PRAS-RAVES MARIA ,  MCCREARY ANDREW ,  VAN VLIET BERNARD ,  HESSELINK MAYKE ,  KRUSE CORNELIS ,  VAN SCHARRENBURG GUSTAAF

IPC: A61K31/423 ,  A61P25/00 ,  C07D263/58 ,  C07D413/12

Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine -D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.