公开(公告)号：AT417834T

公开(公告)日：2009-01-15

申请号：AT06778284

申请日：2006-08-21

Applicant: SOLVAY PHARM BV

Inventor： KOOPMAN THEODORUS ,  KOSTER HENDRIK ,  VAN AMSTERDAM PETER ,  FEENSTRA ROELOF ,  VERHAGE MARINUS ,  MCCREARY ANDREW ,  HESSELINK MAYKE ,  VAN SCHARRENBURG GUSTAAF

IPC: C07D263/58 ,  A61K31/423 ,  A61P25/00 ,  C07D295/24

Abstract: The present invention relates to N-oxides of certain piperazine and piperidine derivatives and to methods for the preparation of these compounds. The invention also relates to the use of compounds disclosed herein for the manufacture of a medicament giving a beneficial effect. A beneficial effect is disclosed herein or apparent to a person skilled in the art from the specification and general knowledge in the art. The invention also relates to the use of a compound of the invention for the manufacture of a medicament for treating or preventing a disease or condition. More particularly, the invention relates to a new use for the treatment of a disease or condition disclosed herein or apparent to a person skilled in the art from the specification and general knowledge in the art. In embodiments of the invention specific compounds disclosed herein are used for the manufacture of a medicament useful in the treatment of CNS-disorders, in particular the treatment of anxiety disorders, including generalized anxiety disorder and panic disorder, obsessive compulsive disorder, aggression, addiction (including craving), depression, autism, vertigo, schizophrenia and other psychotic disorders, Parkinson's disease and disturbances of cognition and memory. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.

公开(公告)号：AT401883T

公开(公告)日：2008-08-15

申请号：AT05850037

申请日：2005-12-06

Applicant: SOLVAY PHARM BV

Inventor： FEENSTRA ROELOF ,  STOIT AXEL ,  TERPSTRA JAN-WILLEM ,  PRAS-RAVES MARIA ,  MCCREARY ANDREW ,  VAN VLIET BERNARD ,  HESSELINK MAYKE ,  KRUSE CORNELIS ,  VAN SCHARRENBURG GUSTAAF

IPC: A61K31/423 ,  A61P25/00 ,  C07D263/58 ,  C07D413/12

Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine -D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.