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公开(公告)号：WO2004043367A2
公开(公告)日：2004-05-27
申请号：PCT/US0335321
申请日：2003-11-06
Applicant: SQUIBB BRISTOL MYERS CO , BARBOSA JOSEPH , PITTS WILLIAM J , GUO JUNQING
Inventor： BARBOSA JOSEPH , PITTS WILLIAM J , GUO JUNQING
IPC: A61K20060101 , A61K31/495 , A61K31/50 , A61K31/519 , A61K31/52 , A61K31/535 , A61K31/55 , A61P1/00 , A61P9/10 , A61P19/00 , C07D471/04 , C07D487/02 , C07D487/04 , C07D498/04 , A61K
CPC classification number: C07D471/04 , C07D487/04
Abstract: Fused heterocyclic compounds of the following Formula (I) wherein R¿1
Abstract translation: 下式（I）的稠合杂环化合物，其中R 1，R 2，R 5，Z，J 1， 和J？ 在本文中描述，并且其类似物可用于治疗白细胞活化相关病症。
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公开(公告)号：WO02102313A3
公开(公告)日：2003-04-03
申请号：PCT/US0219097
申请日：2002-06-17
Applicant: SQUIBB BRISTOL MYERS CO , GUO JUNQING , BARBOSA JOSEPH , PITTS WILLIAM JOHN , CARLSEN MARIANNE , QUESNELLE CLAUDE , DODIER MARCO
Inventor： GUO JUNQING , BARBOSA JOSEPH , PITTS WILLIAM JOHN , CARLSEN MARIANNE , QUESNELLE CLAUDE , DODIER MARCO
IPC: C07D491/113 , A61K31/00 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/522 , A61K31/538 , A61K31/5513 , A61K45/00 , A61P1/00 , A61P1/04 , A61P3/10 , A61P5/14 , A61P9/10 , A61P11/00 , A61P11/04 , A61P11/06 , A61P17/04 , A61P17/06 , A61P17/14 , A61P19/00 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10 , C07D498/10 , A61K31/55 , C07D239/42 , C07D403/04
CPC classification number: C07D417/14 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/522 , C07D403/12 , C07D417/12 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10
Abstract: Pyrimidine phosphodiesterase 7 (PDE 7) inhibitors of the following formula [insert chemical structure here] wherein R1, R2, Z, J and L are described herein, and analogs thereof are provided which are useful in treating T-cell mediated diseases.
Abstract translation: 本文描述了其中R1，R2，Z，J和L的下式[插入化学结构]的嘧啶磷酸二酯酶7（PDE 7）抑制剂及其类似物可用于治疗T细胞介导的疾病。
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3.发明申请BARBITURIC ACID DERIVATIVES AS INHIBITORS OF TNF-ALPHA CONVERTING ENZYME (TACE) AND/OR MATRIX METALLOPROTEINASES 审中-公开用作TNF-α转化酶（TACE）和/或基质金属蛋白酶抑制剂的巴比妥酸衍生物
公开(公告)号：WO03053941A2
公开(公告)日：2003-07-03
申请号：PCT/US0240458
申请日：2002-12-17
Applicant: SQUIBB BRISTOL MYERS CO , DUAN JINGWU , JIANG BIN , CHEN LIHUA , LU ZHONGHUI , BARBOSA JOSEPH , PITTS WILLIAM
Inventor： DUAN JINGWU , JIANG BIN , CHEN LIHUA , LU ZHONGHUI , BARBOSA JOSEPH , PITTS WILLIAM
IPC: A61P9/04 , A61P19/02 , A61P25/28 , C07D239/54 , C07D239/62 , C07D239/70 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/10 , C07D487/10 , C07D491/10 , A61K31/513 , A61K31/515 , C07D239/56 , C07D239/58 , C07D239/68
CPC classification number: C07D239/54 , C07D239/62 , C07D239/70 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/10 , C07D487/10 , C07D491/10
Abstract: The present application describes novel barbituric acid derivatives of formula (I) or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, R2, R3, R4, R5, n, W, U, X, Y, Z, Ua, Xa, Ya, and Za are defined in the present specification, which are useful as TNF-a converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitors.
Abstract translation: 本申请描述了式（I）的新型巴比妥酸衍生物或其药学上可接受的盐或前药形式，其中A，B，L，R1，R2，R3，R4，R5，n，W，U，X，Y，Z ，Ua，Xa，Ya和Za在本说明书中定义，其可用作TNF-α转化酶（TACE）和基质金属蛋白酶（MMP）抑制剂。
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公开(公告)号：WO02087513A2
公开(公告)日：2002-11-07
申请号：PCT/US0214049
申请日：2002-05-01
Applicant: SQUIBB BRISTOL MYERS CO , PITTS WILLIAM , BARBOSA JOSEPH , GUO JUNQING
Inventor： PITTS WILLIAM , BARBOSA JOSEPH , GUO JUNQING
IPC: A61K31/00 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/5377 , A61K31/55 , A61K45/00 , A61K45/06 , A61P1/04 , A61P1/08 , A61P3/10 , A61P5/14 , A61P9/10 , A61P11/00 , A61P11/04 , A61P11/06 , A61P17/00 , A61P17/04 , A61P17/06 , A61P17/14 , A61P19/00 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10 , C07D498/10 , A61K
CPC classification number: C07D417/14 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/522 , C07D403/12 , C07D417/12 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10
Abstract: Fused heterocylic phosphodiesterase 7 (PDE 7) inhibitors of the following formula (I) wherein R1, R2, R5, Z, J1 and J2 are described herein, and analogs thereof are provided which are useful in treating T-cell mediated diseases.
Abstract translation: 本文描述其中R1，R2，R5，Z，J1和J2的下式（I）的融合的杂环磷酸二酯酶7（PDE 7）抑制剂及其类似物可用于治疗T细胞介导的疾病。
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5.发明公开QUINAZOLINE AND PYRIDO 2,3-d|PYRIMIDINE INHIBITORS OF PHOSPHODIESTERASE (PDE) 7 审中-公开喹唑啉和吡啶并2,3--D |磷酸二酯酶（PDE）抑制剂嘧啶7
公开(公告)号：EP1404337A4
公开(公告)日：2006-04-12
申请号：EP02742138
申请日：2002-06-17
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： PITTS WILLIAM J , BARBOSA JOSEPH
IPC: C07D239/95 , C07D417/14 , A61K31/00 , A61K31/42 , A61K31/425 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/5377 , A61K31/551 , A61K31/56 , A61K31/573 , A61K45/00 , A61P1/00 , A61P1/04 , A61P3/10 , A61P5/14 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/04 , A61P11/06 , A61P17/04 , A61P17/06 , A61P17/14 , A61P19/00 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10 , C07D498/10
CPC classification number: C07D403/12 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/522 , C07D401/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10
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Patent Agency Ranking
公开(公告)号：EP1397142A4
公开(公告)日：2004-11-03
申请号：EP02744381
申请日：2002-06-17
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： GUO JUNQING , BARBOSA JOSEPH , PITTS WILLIAM JOHN , CARLSEN MARIANNE , QUESNELLE CLAUDE , DODIER MARCO
IPC: C07D491/113 , A61K31/00 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/522 , A61K31/538 , A61K31/5513 , A61K45/00 , A61P1/00 , A61P1/04 , A61P3/10 , A61P5/14 , A61P9/10 , A61P11/00 , A61P11/04 , A61P11/06 , A61P17/04 , A61P17/06 , A61P17/14 , A61P19/00 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10 , C07D498/10 , A61K31/55 , C07D239/42 , C07D403/04
CPC classification number: C07D417/14 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/522 , C07D403/12 , C07D417/12 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10
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公开(公告)号：EP1383506A4
公开(公告)日：2006-06-21
申请号：EP02731650
申请日：2002-05-01
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： PITTS WILLIAM , BARBOSA JOSEPH , GUO JUNQING
IPC: A61K31/00 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/5377 , A61K31/55 , A61K45/00 , A61K45/06 , A61P1/04 , A61P1/08 , A61P3/10 , A61P5/14 , A61P9/10 , A61P11/00 , A61P11/04 , A61P11/06 , A61P17/00 , A61P17/04 , A61P17/06 , A61P17/14 , A61P19/00 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10 , C07D498/10 , A61K31/495 , A61K31/50 , C07D225/04 , C07D471/00 , C07D487/00
CPC classification number: C07D417/14 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/522 , C07D403/12 , C07D417/12 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10
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公开(公告)号：AU2003228701A1
公开(公告)日：2003-11-10
申请号：AU2003228701
申请日：2003-04-24
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： PITTS WILLIAM J , KIM SOONG-HOON , BARBOSA JOSEPH , VACCARO WAYNE
IPC: A61P29/00 , A61P35/00 , C07D487/10 , C07D471/10 , A61K31/527 , C07D209/00 , C07D239/62 , C07D239/66
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公开(公告)号：HU0600228A2
公开(公告)日：2006-07-28
申请号：HU0600228
申请日：2002-06-17
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： VACCARO WAYNE , ROBERGE JACQUES Y , LEFTHERIS KATERINA , PITTS WILLIAM J , BARBOSA JOSEPH
IPC: C07D239/95 , C07D473/16 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/5377 , A61K31/551 , A61K31/56 , A61K31/573 , A61K45/00 , A61P1/00 , A61P1/04 , A61P3/10 , A61P5/14 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/04 , A61P11/06 , A61P17/04 , A61P17/06 , A61P17/14 , A61P19/00 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07D401/12 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D487/04 , C07D491/10 , C07D498/10
Abstract: Pyrido[2,3-d]pyrimidine phosphodiesterase 7 (PDE 7) inhibitors are provided which are useful in treating T-cell mediated diseases, said inhibitors include: (i) 2-[[4-[[[4-(Aminosulfonyl)phenyl]methyl]amino]pyrido[2,3-d]pyrimidin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid, ethyl ester; and 4-Methyl-2-[[4-[[[4-(methylsulfonyl)phenyl]methyl]amino]pyrido[2,3-d]pyrimidin-2-yl]amino]-5-thiazolecarboxylic acid, ethyl ester; or (ii) an enantiomer, diastereomer, tautomer or pharmaceutically acceptable salt of (i).
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公开(公告)号：AU2002357312A1
公开(公告)日：2003-07-09
申请号：AU2002357312
申请日：2002-12-17
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： PITTS WILLIAM , DUAN JINGWU , JIANG BIN , CHEN LIHUA , LU ZHONGHUI , BARBOSA JOSEPH
IPC: A61P9/04 , A61P19/02 , A61P25/28 , C07D239/54 , C07D239/62 , C07D239/70 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/10 , C07D487/10 , C07D491/10 , A61K31/513 , A61K31/515 , C07D239/56 , C07D239/58 , C07D239/68
Abstract: The present application describes novel barbituric acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, R2, R3, R4, R5, n, W, U, X, Y, Z, Ua, Xa, Ya, and Za are defined in the present specification, which are useful as TNF-alpha converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitors.
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