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公开(公告)号：WO02088079A3
公开(公告)日：2003-01-30
申请号：PCT/US0213628
申请日：2002-04-29
Applicant: SQUIBB BRISTOL MYERS CO , PITTS WILLIAM JOHN , WATSON ANDREW J , DODD JOHN H
Inventor： PITTS WILLIAM JOHN , WATSON ANDREW J , DODD JOHN H
IPC: A61K31/00 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/5377 , A61K31/55 , A61K45/00 , A61K45/06 , A61P1/04 , A61P1/08 , A61P3/10 , A61P5/14 , A61P9/10 , A61P11/00 , A61P11/04 , A61P11/06 , A61P17/00 , A61P17/04 , A61P17/06 , A61P17/14 , A61P19/00 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10 , C07D498/10
CPC classification number: C07D417/14 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/522 , C07D403/12 , C07D417/12 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10
Abstract: Dual inhibitors of PDE7 and PDE4, together with their use to treat leukocyte activation-associated disorders (including transplant rejection, rheumatoid arthritis, inflammatory bowel disease, psoriasis, asthma, chronic obstructive pulmonary disease, lupus and multiple sclerosis ), are provided herein.
Abstract translation: PDE7和PDE4的双重抑制剂及其用于治疗白细胞活化相关疾病（包括移植排斥，类风湿性关节炎，炎性肠病，牛皮癣，哮喘，慢性阻塞性肺病，狼疮和多发性硬化）的用途。
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公开(公告)号：WO02102313A3
公开(公告)日：2003-04-03
申请号：PCT/US0219097
申请日：2002-06-17
Applicant: SQUIBB BRISTOL MYERS CO , GUO JUNQING , BARBOSA JOSEPH , PITTS WILLIAM JOHN , CARLSEN MARIANNE , QUESNELLE CLAUDE , DODIER MARCO
Inventor： GUO JUNQING , BARBOSA JOSEPH , PITTS WILLIAM JOHN , CARLSEN MARIANNE , QUESNELLE CLAUDE , DODIER MARCO
IPC: C07D491/113 , A61K31/00 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/522 , A61K31/538 , A61K31/5513 , A61K45/00 , A61P1/00 , A61P1/04 , A61P3/10 , A61P5/14 , A61P9/10 , A61P11/00 , A61P11/04 , A61P11/06 , A61P17/04 , A61P17/06 , A61P17/14 , A61P19/00 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10 , C07D498/10 , A61K31/55 , C07D239/42 , C07D403/04
CPC classification number: C07D417/14 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/522 , C07D403/12 , C07D417/12 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10
Abstract: Pyrimidine phosphodiesterase 7 (PDE 7) inhibitors of the following formula [insert chemical structure here] wherein R1, R2, Z, J and L are described herein, and analogs thereof are provided which are useful in treating T-cell mediated diseases.
Abstract translation: 本文描述了其中R1，R2，Z，J和L的下式[插入化学结构]的嘧啶磷酸二酯酶7（PDE 7）抑制剂及其类似物可用于治疗T细胞介导的疾病。
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公开(公告)号：WO02088080A3
公开(公告)日：2003-03-13
申请号：PCT/US0213742
申请日：2002-04-30
Applicant: SQUIBB BRISTOL MYERS CO , PITTS WILLIAM JOHN , WATSON ANDREW J , DODD JOHN H
Inventor： PITTS WILLIAM JOHN , WATSON ANDREW J , DODD JOHN H
IPC: A61K31/00 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/5377 , A61K31/55 , A61K45/00 , A61K45/06 , A61P1/04 , A61P1/08 , A61P3/10 , A61P5/14 , A61P9/10 , A61P11/00 , A61P11/04 , A61P11/06 , A61P17/00 , A61P17/04 , A61P17/06 , A61P17/14 , A61P19/00 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10 , C07D498/10
CPC classification number: C07D417/14 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/522 , C07D403/12 , C07D417/12 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10
Abstract: Dual inhibitors of PDE7 and PDE4, together with their use to treat leukocyte activation-associated disorders (including transplant rejection, rheumatoid arthritis, inflammatory bowel disease, psoriasis, asthma, chronic obstructive pulmonary disease, lupus and multiple sclerosis), are provided herein.
Abstract translation: PDE7和PDE4的双重抑制剂及其用于治疗白细胞活化相关疾病（包括移植排斥，类风湿性关节炎，炎性肠病，牛皮癣，哮喘，慢性阻塞性肺病，狼疮和多发性硬化）的用途。
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4.发明公开COMPOUNDS DERIVED FROM AN AMINE NUCLEUS THAT ARE INHIBITORS OF IMPDH ENZYME 审中-公开VON EINEM AMINKERNABKÖMMLICHEVERBINDUNGEN DIE IMPDH-ENZYME HEMMEN
公开(公告)号：EP1126843A4
公开(公告)日：2005-06-15
申请号：EP99955142
申请日：1999-10-22
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： LIU CHUNJIAN , DHAR T G MURALI , GU HENRY H , IWANOWICZ EDWIN J , LEFTHERIS KATERINA , PITTS WILLIAM JOHN
IPC: A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/513 , A61K31/53 , A61K31/5377 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07D263/32 , C07D263/48 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D521/00
CPC classification number: C07D231/12 , C07D233/56 , C07D249/08 , C07D263/32 , C07D263/48 , C07D413/12 , C07D413/14 , C07D417/12
Abstract: The present invention discloses the identification of the novel inhibitors of IMPDH (inosine-5'-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH mediated diseases, such as transplant rejection and autoimmune diseases.
Abstract translation: 本发明公开了IMPDH（肌苷-5'-单磷酸脱氢酶）的新型抑制剂的鉴定。 本文公开的化合物和药物组合物可用于治疗或预防IMPDH介导的疾病，例如移植排斥和自身免疫性疾病。
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公开(公告)号：EP1397142A4
公开(公告)日：2004-11-03
申请号：EP02744381
申请日：2002-06-17
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： GUO JUNQING , BARBOSA JOSEPH , PITTS WILLIAM JOHN , CARLSEN MARIANNE , QUESNELLE CLAUDE , DODIER MARCO
IPC: C07D491/113 , A61K31/00 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/522 , A61K31/538 , A61K31/5513 , A61K45/00 , A61P1/00 , A61P1/04 , A61P3/10 , A61P5/14 , A61P9/10 , A61P11/00 , A61P11/04 , A61P11/06 , A61P17/04 , A61P17/06 , A61P17/14 , A61P19/00 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10 , C07D498/10 , A61K31/55 , C07D239/42 , C07D403/04
CPC classification number: C07D417/14 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/522 , C07D403/12 , C07D417/12 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10
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Patent Agency Ranking
公开(公告)号：EP1383743A4
公开(公告)日：2006-04-12
申请号：EP02725882
申请日：2002-04-30
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： PITTS WILLIAM JOHN , WATSON ANDREW J , DODD JOHN H
IPC: A61K31/00 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/5377 , A61K31/55 , A61K45/00 , A61K45/06 , A61P1/04 , A61P1/08 , A61P3/10 , A61P5/14 , A61P9/10 , A61P11/00 , A61P11/04 , A61P11/06 , A61P17/00 , A61P17/04 , A61P17/06 , A61P17/14 , A61P19/00 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10 , C07D498/10 , C07D211/00
CPC classification number: C07D417/14 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/522 , C07D403/12 , C07D417/12 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10
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公开(公告)号：CA2450934A1
公开(公告)日：2002-12-27
申请号：CA2450934
申请日：2002-06-17
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： QUESNELLE CLAUDE , DODIER MARCO , PITTS WILLIAM JOHN , CARLSEN MARIANNE , GUO JUNQING , BARBOSA JOSEPH
IPC: C07D491/113 , A61K31/00 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/522 , A61K31/538 , A61K31/5513 , A61K45/00 , A61P1/00 , A61P1/04 , A61P3/10 , A61P5/14 , A61P9/10 , A61P11/00 , A61P11/04 , A61P11/06 , A61P17/04 , A61P17/06 , A61P17/14 , A61P19/00 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10 , C07D498/10 , A61K31/5375 , A61K31/55 , C07D239/42 , C07D403/04
Abstract: Pyrimidine phosphodiesterase 7 (PDE 7) inhibitors of the following formula [insert chemical structure here] wherein R1, R2, Z, J and L are described herein, and analogs thereof are provided which are useful in treating T-cell mediated diseases.
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公开(公告)号：AU764479B2
公开(公告)日：2003-08-21
申请号：AU1131500
申请日：1999-10-22
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： LIU CHUNJIAN , DHAR T G MURALI , GU HENRY H , IWANOWICZ EDWIN J , LEFTHERIS KATERINA , PITTS WILLIAM JOHN
IPC: A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/513 , A61K31/53 , A61K31/5377 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07D263/32 , C07D263/48 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D521/00
Abstract: The present invention discloses the identification of the novel inhibitors of IMPDH (inosine-5'-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH mediated diseases, such as transplant rejection and autoimmune diseases.
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公开(公告)号：UY27276A1
公开(公告)日：2003-07-31
申请号：UY27276
申请日：2002-04-30
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： WATSON ANDREW J , DODD JOHN H , PITTS WILLIAM JOHN
IPC: A61K31/00 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/522 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/16 , C07D487/04 , C07D491/10 , C07D498/10 , C07D239/28 , C07D277/32 , C07D473/34 , C07D473/40
Abstract: Se proporcionan en la presente inhibidores duales de PDE7 Y PDE4, junto con su uso para el tratamiento de trastornos asociados con la activacinn del leucocito (que incluyen el rechazo al trasplante, artritis reumatoide, enfermedad inflamatoria del intestino, psoriasis, asma, enfermedad pulmonar obstructiva crónica, lupus y esclerosis múltiples).
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公开(公告)号：AU1131500A
公开(公告)日：2000-05-22
申请号：AU1131500
申请日：1999-10-22
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： LIU CHUNJIAN , DHAR T G MURALI , GU HENRY H , IWANOWICZ EDWIN J , LEFTHERIS KATERINA , PITTS WILLIAM JOHN
IPC: A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/513 , A61K31/53 , A61K31/5377 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07D263/32 , C07D263/48 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D521/00
Abstract: The present invention discloses the identification of the novel inhibitors of IMPDH (inosine-5'-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH mediated diseases, such as transplant rejection and autoimmune diseases.
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