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公开(公告)号：EP1097236A4
公开(公告)日：2006-10-04
申请号：EP99933744
申请日：1999-07-07
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： DONOVAN MARY JO , GOLDBERG STEVEN , HANSON RONALD L , JASS PAUL A , LI WEN-SEN , PATEL RAMESH N , RAMIG KEITH , SZARKA LASZLO J , VENIT JOHN J
IPC: C12N15/09 , C12N1/19 , C12N9/06 , C12P7/62 , C12P13/00 , C12P17/04 , C12P17/06 , C12P41/00 , C12R1/01 , C12R1/84 , C12P13/04 , C07C59/185 , C07C229/24 , C12N1/16 , C12N1/20 , C12N9/02 , C12N15/00 , C12N15/70 , C12N15/81 , C12R1/19
CPC classification number: C12N9/0018 , C12P7/62 , C12P41/002 , C12P41/006
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公开(公告)号：AU2003203698B2
公开(公告)日：2004-06-10
申请号：AU2003203698
申请日：2003-03-11
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： PATEL RAMESH N , WENSEN LI , JASS PAUL A , RAMIG KEITH , HANSON RONALD L , GOLDBERG STEVEN , DONOVAN MARY JO , VENIT JOHN J , SZARKA LASZLO J
IPC: C12P007/00
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Patent Agency Ranking
公开(公告)号：CA2337230A1
公开(公告)日：2000-01-27
申请号：CA2337230
申请日：1999-07-07
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： VENIT JOHN J , SZARKA LASZLO J , RAMIG KEITH , PATEL RAMESH N , DONOVAN MARY JO , LI WEN-SEN , JASS PAUL A , HANSON RONALD L , GOLDBERG STEVEN
IPC: C12N15/09 , C12N1/19 , C12N9/06 , C12P7/62 , C12P13/00 , C12P17/04 , C12P17/06 , C12P41/00 , C12R1/01 , C12R1/84 , C12P7/00 , C12P17/00 , C12P17/02
Abstract: Processes for stereoselective enzymatic conversion of certain keto carboxyli c acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme.
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公开(公告)号：BR0208265A
公开(公告)日：2004-03-02
申请号：BR0208265
申请日：2002-03-06
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： PATEL RAMESH , GOSWAMI ANIMESH , CHU LINDA , NANDURI VENKATA , GOLDBERG STEVEN , JOHNSTON ROBERT , DONOVAN MARY JO , MIRFAKHRAE K DAVID
Abstract: The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of gamma-secretase useful in the treatment of Alzheimer's disease.
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公开(公告)号：AU755530B2
公开(公告)日：2002-12-12
申请号：AU4973599
申请日：1999-07-07
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： DONOVAN MARY JO , GOLDBERG STEVEN , HANSON RONALD L , JASS PAUL A , LI WEN-SEN , PATEL RAMESH N , RAMIG KEITH , SZARKA LASZLO J , VENIT JOHN J
IPC: C12N15/09 , C12N1/19 , C12N9/06 , C12P7/62 , C12P13/00 , C12P17/04 , C12P17/06 , C12P41/00 , C12R1/01 , C12R1/84 , C12P7/00 , C12P17/00 , C12P17/02
Abstract: Processes for stereoselective enzymatic conversion of certain keto carboxylic acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme.
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公开(公告)号：AU4973599A
公开(公告)日：2000-02-07
申请号：AU4973599
申请日：1999-07-07
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： DONOVAN MARY JO , GOLDBERG STEVEN , HANSON RONALD L , JASS PAUL A , LI WEN-SEN , PATEL RAMESH N , RAMIG KEITH , SZARKA LASZLO J , VENIT JOHN J
IPC: C12N15/09 , C12N1/19 , C12N9/06 , C12P7/62 , C12P13/00 , C12P17/04 , C12P17/06 , C12P41/00 , C12R1/01 , C12R1/84 , C12P7/00 , C12P17/00 , C12P17/02
Abstract: Processes for stereoselective enzymatic conversion of certain keto carboxylic acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme.
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公开(公告)号：CA2441267A1
公开(公告)日：2002-10-03
申请号：CA2441267
申请日：2002-03-06
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： PATEL RAMESH , GOSWAMI ANIMESH , GOLDBERG STEVEN , CHU LINDA , NANDURI VENKATA , MIRFAKHRAE K DAVID , DONOVAN MARY JO , JOHNSTON ROBERT
Abstract: The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of .gamma.- secretase useful in the treatment of Alzheimer's disease.
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