公开(公告)号：WO02053724A3

公开(公告)日：2003-01-16

申请号：PCT/US0149115

申请日：2001-12-18

Applicant: SQUIBB BRISTOL MYERS CO ,  PATEL RAMESH ,  BRZOZOWSKI DAVID ,  NANDURI VENKATA B

Inventor： PATEL RAMESH ,  BRZOZOWSKI DAVID ,  NANDURI VENKATA B

IPC: C12Q1/04 ,  C12N1/00 ,  C12N1/20 ,  C12P13/00 ,  C12P13/04 ,  C12P17/00 ,  C12P17/10 ,  C12P41/00 ,  C12R1/01 ,  C12N9/78

CPC classification number: C12P41/007 ,  C12P17/00 ,  C12P17/10 ,  C12P41/004

Abstract: Provided is a method of deprotecting a hydroxide or amine protected with a group of formula ArC (R)H-(CH2)n-O-C(=O)- where the substituents are as described below, the method comprising: contacting the protected hydroxide or amine with an enzyme effective to remove the protecting group; and recovering the amine. Also provided is a method of isolating a bacteria producing an enzyme effective to remove a protecting group comprising: growing prospective bacteria on a medium having a growth selective amount of an amine compound that is protected as above; and isolating bacteria that grow on said medium.

Abstract translation: 本发明提供了用下式所示保护的氢氧化物或胺基（H）（R）H（CH 2）n OC（= O） - 基取代的方法，其中取代基如下所述，该方法包括：使被保护的氢氧化物 或胺与有效去除保护基团的酶反应; 并回收胺。 还提供了分离产生有效去除保护基团的酶的细菌的方法，包括：在具有生长选择量的如上所述保护的胺化合物的培养基上培养未来细菌; 并分离在所述培养基上生长的细菌。

公开(公告)号：AT431422T

公开(公告)日：2009-05-15

申请号：AT01959109

申请日：2001-07-20

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PATEL RAMESH ,  CHU LINDA

IPC: C12P7/02 ,  C12P13/02 ,  C07D301/26 ,  C07D303/36 ,  C12P13/00 ,  C12R1/01 ,  C12S99/00

Abstract: The present invention relates to a process for the stereoselective enzymatic reduction of 1-halo-2-oxo-3-(protected)amino-4-substituted-butanes utilizing certain species of Rhodococcus and Brevibacterium. The product 1-halo-2-hydroxy-3-(protected)amino-4-substituted-butanes, which are useful as intermediates in the synthesis of compounds that are inhibitors of ACE, renin and HIV proteases, are obtained in high yield and, particularly, in very high diastereomeric purity. The process is advantageously highly selective for the (3S,2R) enantiomer of the product.

公开(公告)号：AU2002232651B2

公开(公告)日：2007-04-19

申请号：AU2002232651

申请日：2001-12-18

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PATEL RAMESH ,  BRZOZOWSKI DAVID ,  NANDURI VENKATA B

IPC: C12Q1/04 ,  C12N1/00 ,  C12N1/20 ,  C12P13/00 ,  C12P13/04 ,  C12P17/00 ,  C12P17/10 ,  C12P41/00 ,  C12R1/01

Abstract: Provided is a method of deprotecting a hydroxide or amine protected with a group of formulawhere the substituents are as described below, the method comprising: contacting the protected hydroxide or amine with an enzyme effective to remove the protecting group; and recovering the amine. Also provided is a method of isolating a bacteria producing an enzyme effective to remove a protecting group comprising: growing prospective bacteria on a medium having a growth selective amount of an amine compound that is protected as above; and isolating bacteria that grow on said medium.

公开(公告)号：BR0208265A

公开(公告)日：2004-03-02

申请号：BR0208265

申请日：2002-03-06

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PATEL RAMESH ,  GOSWAMI ANIMESH ,  CHU LINDA ,  NANDURI VENKATA ,  GOLDBERG STEVEN ,  JOHNSTON ROBERT ,  DONOVAN MARY JO ,  MIRFAKHRAE K DAVID

IPC: C12N15/09 ,  C12P7/22 ,  C12R1/84 ,  C12P41/00

Abstract: The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of gamma-secretase useful in the treatment of Alzheimer's disease.

公开(公告)号：CZ20032496A3

公开(公告)日：2003-12-17

申请号：CZ20032496

申请日：2002-03-06

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PATEL RAMESH ,  GOSWAMI ANIMESH ,  CHU LINDA N ,  NANDURI VENKATA B ,  GOLDBERG STEVEN L ,  JOHNSTON ROBERT M ,  DONOVAN MARY JO ,  MIRFAKHRAE K DAVID

IPC: C12N15/09 ,  C12P7/22 ,  C12R1/84

Abstract: The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of gamma-secretase useful in the treatment of Alzheimer's disease.

公开(公告)号：AU2002232651B9

公开(公告)日：2007-05-31

申请号：AU2002232651

申请日：2001-12-18

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： NANDURI VENKATA B ,  BRZOZOWSKI DAVID ,  PATEL RAMESH

IPC: C12Q1/04 ,  C12N1/00 ,  C12N1/20 ,  C12P13/00 ,  C12P13/04 ,  C12P17/00 ,  C12P17/10 ,  C12P41/00 ,  C12R1/01

Abstract: Provided is a method of deprotecting a hydroxide or amine protected with a group of formulawhere the substituents are as described below, the method comprising: contacting the protected hydroxide or amine with an enzyme effective to remove the protecting group; and recovering the amine. Also provided is a method of isolating a bacteria producing an enzyme effective to remove a protecting group comprising: growing prospective bacteria on a medium having a growth selective amount of an amine compound that is protected as above; and isolating bacteria that grow on said medium.

公开(公告)号：MXPA03008437A

公开(公告)日：2004-01-29

申请号：MXPA03008437

申请日：2002-03-06

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PATEL RAMESH

IPC: C12P7/22 ,  C12R1/84 ,  C12N15/09 ,  C12P41/00

公开(公告)号：CA2441267A1

公开(公告)日：2002-10-03

申请号：CA2441267

申请日：2002-03-06

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PATEL RAMESH ,  GOSWAMI ANIMESH ,  GOLDBERG STEVEN ,  CHU LINDA ,  NANDURI VENKATA ,  MIRFAKHRAE K DAVID ,  DONOVAN MARY JO ,  JOHNSTON ROBERT

IPC: C12N15/09 ,  C12P7/22 ,  C12R1/84 ,  C12P41/00

Abstract: The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of .gamma.- secretase useful in the treatment of Alzheimer's disease.

公开(公告)号：AU2002232651A1

公开(公告)日：2002-07-16

申请号：AU2002232651

申请日：2001-12-18

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PATEL RAMESH ,  BRZOZOWSKI DAVID ,  NANDURI VENKATA B

IPC: C12Q1/04 ,  C12N1/00 ,  C12N1/20 ,  C12P13/00 ,  C12P13/04 ,  C12P17/00 ,  C12P17/10 ,  C12P41/00 ,  C12R1/01

Abstract: Provided is a method of deprotecting a hydroxide or amine protected with a group of formulawhere the substituents are as described below, the method comprising: contacting the protected hydroxide or amine with an enzyme effective to remove the protecting group; and recovering the amine. Also provided is a method of isolating a bacteria producing an enzyme effective to remove a protecting group comprising: growing prospective bacteria on a medium having a growth selective amount of an amine compound that is protected as above; and isolating bacteria that grow on said medium.

公开(公告)号：CA2433628A1

公开(公告)日：2002-07-11

申请号：CA2433628

申请日：2001-12-18

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： NANDURI VENKATA B ,  BRZOZOWSKI DAVID ,  PATEL RAMESH

IPC: C12Q1/04 ,  C12N1/00 ,  C12N1/20 ,  C12P13/00 ,  C12P13/04 ,  C12P17/00 ,  C12P17/10 ,  C12P41/00 ,  C12R1/01 ,  C12N9/78

Abstract: Provided is a method of deprotecting a hydroxide or amine protected with a group of formula ArC*(R)H-(CH2)n-O-C(=O)- where the substituents are as described below, the method comprising: contacting the protected hydroxide o r amine with an enzyme effective to remove the protecting group; and recoverin g the amine. Also provided is a method of isolating a bacteria producing an enzyme effective to remove a protecting group comprising: growing prospectiv e bacteria on a medium having a growth selective amount of an amine compound that is protected as above; and isolating bacteria that grow on said medium.