公开(公告)号：WO2006029079A3

公开(公告)日：2006-06-01

申请号：PCT/US2005031541

申请日：2005-09-02

Applicant: SQUIBB BRISTOL MYERS CO ,  VEMISHETTI PURUSHOTHAM ,  CHADWICK SCOTT T ,  COSTELLO CARRIE A ,  DESIKAN SRIDHAR ,  REIFF EMILY A

Inventor： VEMISHETTI PURUSHOTHAM ,  CHADWICK SCOTT T ,  COSTELLO CARRIE A ,  DESIKAN SRIDHAR ,  REIFF EMILY A

IPC: C07D265/18

CPC classification number: C07D265/18

Abstract: The present invention provides novel methods for the synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one of formula (III) which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

Abstract translation: 本发明提供了合成式（III）的（S）-6-氯-4-环丙基乙炔基-4-三氟甲基-1,4-二氢-2H-3,1-苯并恶嗪-2-酮的新方法，它是 可用作人类免疫缺陷病毒（HIV）逆转录酶抑制剂。

公开(公告)号：EP1751158A4

公开(公告)日：2009-05-13

申请号：EP05756404

申请日：2005-06-03

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： ZHOU MAOTANG X ,  REIFF EMILY A ,  VEMISHETTI PURUSHOTHAM ,  PENDRI YADAGIRI R ,  SINGH AMBARISH K ,  PRASAD SIVA J ,  DHOKTE ULHAS P ,  QIAN XINHUA ,  MOUNTFORD PIA ,  HARTUNG KERRY B ,  SAILES HELEN

IPC: C07D473/18 ,  C07C41/16 ,  C07C41/26 ,  C07C43/178 ,  C07C43/215 ,  C07C43/23 ,  C07D473/10 ,  C07F7/04 ,  C07F7/08 ,  C07F7/18

CPC classification number: C07C41/16 ,  C07C41/26 ,  C07C2601/10 ,  C07D473/18 ,  C07F7/0854 ,  C07F7/1892 ,  C07C43/23 ,  C07C43/215

Abstract: Processes for preparing entecavir (I) and novel intermediates thereof using carbon-silicon oxidation.

公开(公告)号：EP1786791A4

公开(公告)日：2009-04-15

申请号：EP05794096

申请日：2005-09-02

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： VEMISHETTI PURUSHOTHAM ,  CHADWICK SCOTT T ,  COSTELLO CARRIE A ,  DESIKAN SRIDHAR ,  REIFF EMILY A

IPC: C07D265/18

CPC classification number: C07D265/18

Abstract: The present invention provides novel methods for the synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one of formula (III) which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

公开(公告)号：ZA200610141B

公开(公告)日：2008-09-25

申请号：ZA200610141

申请日：2006-12-04

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： ZHOU MAOTANG X ,  PURUSHOTHAM VEMISHETTI ,  SIGH AMBARISH K ,  DHOKTE ULHAS P ,  PIA MOUNTFORD ,  HELEN SAILES ,  REIFF EMILY A ,  PENDRI YADAGIRI R ,  PRASAD SIVA J ,  XINHUA QIAN ,  HARTUNG KERRY B

IPC: C07D20090101

公开(公告)号：BRPI0514842A

公开(公告)日：2008-06-24

申请号：BRPI0514842

申请日：2005-09-02

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： VEMISHETTI PURUSHOTHAM ,  CHADWICK SCOTT T ,  COSTELLO CARRIE A ,  DESIKAN SRIDHAR ,  REIFF EMILY A

IPC: C07D265/18

Abstract: The present invention provides novel methods for the synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one of formula (III) which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

公开(公告)号：CA2578966A1

公开(公告)日：2006-03-16

申请号：CA2578966

申请日：2005-09-02

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： DESIKAN SRIDHAR ,  REIFF EMILY A ,  COSTELLO CARRIE A ,  VEMISHETTI PURUSHOTHAM ,  CHADWICK SCOTT T

IPC: C07D265/18

Abstract: The present invention provides novel methods for the synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one of formula (III) which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

公开(公告)号：CA2569484A1

公开(公告)日：2005-12-15

申请号：CA2569484

申请日：2005-06-03

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： REIFF EMILY A ,  HARTUNG KERRY B ,  PRASAD SIVA J ,  SAILES HELEN ,  DHOKTE ULHAS P ,  ZHOU MAOTANG X ,  QIAN XINHUA ,  VEMISHETTI PURUSHOTHAM ,  PENDRI YADAGIRI R ,  SINGH AMBARISH K ,  MOUNTFORD PIA

IPC: C07D473/18 ,  C07C41/16 ,  C07C41/26 ,  C07C43/178 ,  C07C43/215 ,  C07C43/23 ,  C07D473/10 ,  C07F7/04 ,  C07F7/08 ,  C07F7/18

Abstract: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.

公开(公告)号：AU2005251377A1

公开(公告)日：2005-12-15

申请号：AU2005251377

申请日：2005-06-03

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： HARTUNG KERRY B ,  SINGH AMBARISH K ,  PRASAD SIVA J ,  REIFF EMILY A ,  QIAN XINHUA ,  VEMISHETTI PURUSHOTHAM ,  DHOKTE ULHAS P ,  MOUNTFORD PIA ,  PENDRI YADAGIRI R ,  SAILES HELEN ,  ZHOU MAOTANG X

IPC: C07C41/16 ,  C07C41/26 ,  C07C43/178 ,  C07C43/215 ,  C07C43/23 ,  C07D473/10 ,  C07D473/18 ,  C07F7/04 ,  C07F7/08 ,  C07F7/18

Abstract: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.

公开(公告)号：AU2005282576B2

公开(公告)日：2011-11-24

申请号：AU2005282576

申请日：2005-09-02

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： COSTELLO CARRIE A ,  REIFF EMILY A ,  PURUSHOTHAM VEMISHETTI ,  SRIDHAR DESIKAN ,  CHADWICK SCOTT T

IPC: C07D265/18

Abstract: The present invention provides novel methods for the synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one of formula (III) which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

公开(公告)号：MXPA06014003A

公开(公告)日：2007-02-08

申请号：MXPA06014003

申请日：2005-06-03

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PENDRI YADAGIRI R ,  QIAN XINHUA ,  VEMISHETTI PURUSHOTHAM ,  ZHOU MAOTANG X ,  REIFF EMILY A ,  SINGH AMBARISH K ,  PRASAD SIVA J ,  DHOKTE ULHAS P ,  MOUNTFORD PIA ,  HARTUNG KERRY B ,  SAILES HELEN

IPC: C07D473/18 ,  C07C41/16 ,  C07C41/26 ,  C07C43/178 ,  C07C43/215 ,  C07C43/23 ,  C07D473/10 ,  C07F7/04 ,  C07F7/08 ,  C07F7/18

Abstract: Se describen los procesos para la preparacion del entecavir y los nuevos intermediarios del mismo, utilizando la oxidacion de carbono-silicio (Ver formula I).