公开(公告)号：EP1644384A4

公开(公告)日：2009-09-02

申请号：EP03812974

申请日：2003-12-10

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PENDRI YADAGIRI R ,  CHEN CHUNG-PIN H ,  PATEL SUNIL S ,  EVANS JEFFREY M ,  LIANG JING ,  KRONENTHAL DAVID R ,  POWERS GERALD L ,  PRASAD SIVA JOSYULA ,  BIEN JEFFREY T ,  SHI ZHONGPING ,  PATEL RAMESH N ,  CHAN YEUNG Y ,  RIJHWANI SUSHIL K ,  SINGH AMBARISH K ,  WANG SHAOPENG ,  STOJANOVIC MILAN ,  POLNIASZEK RICHARD ,  LEWIS CHARLES ,  THOTTATHIL JOHN ,  KRISHNAMURTY DHILEEPKUMAR

IPC: C07D473/18 ,  C07D473/12 ,  C07F7/08 ,  C07F7/18

CPC classification number: C07F7/1856 ,  C07D473/18 ,  C07F7/0812 ,  C07F7/0814 ,  C07F7/0818 ,  C07F7/0827 ,  C07F7/083

Abstract: Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.

公开(公告)号：EP1751158A4

公开(公告)日：2009-05-13

申请号：EP05756404

申请日：2005-06-03

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： ZHOU MAOTANG X ,  REIFF EMILY A ,  VEMISHETTI PURUSHOTHAM ,  PENDRI YADAGIRI R ,  SINGH AMBARISH K ,  PRASAD SIVA J ,  DHOKTE ULHAS P ,  QIAN XINHUA ,  MOUNTFORD PIA ,  HARTUNG KERRY B ,  SAILES HELEN

IPC: C07D473/18 ,  C07C41/16 ,  C07C41/26 ,  C07C43/178 ,  C07C43/215 ,  C07C43/23 ,  C07D473/10 ,  C07F7/04 ,  C07F7/08 ,  C07F7/18

CPC classification number: C07C41/16 ,  C07C41/26 ,  C07C2601/10 ,  C07D473/18 ,  C07F7/0854 ,  C07F7/1892 ,  C07C43/23 ,  C07C43/215

Abstract: Processes for preparing entecavir (I) and novel intermediates thereof using carbon-silicon oxidation.

公开(公告)号：PL397715A1

公开(公告)日：2012-03-26

申请号：PL39771503

申请日：2003-12-10

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PENDRI YADAGIRI ,  CHEN CHUNG-PIN H ,  PATEL SUNIL S ,  EVANS JEFFREY M ,  LIANG JING ,  KRONENTHAL DAVID R ,  POWERS GERALD L ,  PRASAD SIVA JOSYULA ,  BIEN JEFFREY T ,  SHI ZHONGPING ,  CHAN YEUNG Y ,  RIJHWANI SUSHIL K ,  SINGH AMBARISH K ,  WANG SHAOPENG ,  STOJANOVIC MILAN ,  POLNIASZEK RICHARD ,  LEWIS CHARLES ,  THOTTATHIL JOHN K ,  KRISHNAMURTY DHILEEPKUMAR ,  ZHOU MAOTANG X ,  VEMISHETTI PURUSHOTHAM ,  BANERJEE AMIT ,  PATEL RAMESH N ,  KUCERA DAVID J

IPC: C07F7/08 ,  C07D473/12 ,  C07D473/18 ,  C07F7/18

公开(公告)号：BR0317255A

公开(公告)日：2005-11-08

申请号：BR0317255

申请日：2003-12-10

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： BANERJEE AMIT ,  KUCERA DAVID J ,  PENDRI YADAGIRI ,  CHEN CHUNG-PIN ,  PATEL SUNIL S ,  EVANS JEFFREY M ,  LIANG JING ,  KRONENTHAL DAVID R ,  POWERS GERALD L ,  PRASAD SIVA JOSYULA ,  BIEN JEFFREY T ,  SHI ZHONGPING ,  PATEL RAMESH N ,  CHAN YEUNG Y ,  RIJHWANI SUSHIL K ,  SINGH AMBARISH K ,  WANG SHAOPENG ,  STOJANOVIC MILAN ,  POLNIASZEK RICHARD ,  LEWIS CHARLES ,  THOTTATHIL JOHN ,  KRISHNAMURTY DHILEEPKUMAR ,  ZHOU MAOTANG X ,  VEMISHETTI PURUSHOTHAM

IPC: C07D473/12 ,  C07D473/18 ,  C07F7/08 ,  C07F7/18

Abstract: The invention refers to a method for isolating entecavir or an entecavir intermediate from a diluted mixture, the diluted mixture comprising entecavir and water or a mixture comprising an entecavir intermediate and other process reagents comprising: (a) adsorbing the diluted mixture onto a hydrophobic resin bed; (b) washing the resin bed with water to remove salt; and (c) eluting the entecavir or entecavir intermediate from the resin bed with an organic solvent.

公开(公告)号：DK1644384T3

公开(公告)日：2013-02-11

申请号：DK03812974

申请日：2003-12-10

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PENDRI YADAGIRI R ,  CHEN CHUNG-PIN H ,  PATEL SUNIL S ,  EVANS JEFFREY M ,  LIANG JING ,  KRONENTHAL DAVID R ,  POWERS GERALD L ,  PRASAD SIVA JOSYULA ,  BIEN JEFFREY T ,  SHI ZHONGPING ,  PATEL RAMESH N ,  CHAN YEUNG Y ,  RIJHWANI SUSHIL K ,  SINGH AMBARISH K ,  WANG SHAOPENG ,  STOJANOVIC MILAN ,  POLNIASZEK RICHARD ,  LEWIS CHARLES ,  THOTTATHIL JOHN ,  VEMISHETTI PURUSHOTHAM ,  KRISHNAMURTY DHILEEPKUMAR ,  ZHOU MAOTANG X ,  BANERJEE AMIT ,  KUCERA DAVID J

IPC: C07D473/18 ,  C07D473/12 ,  C07F7/08 ,  C07F7/18

公开(公告)号：MXPA06014003A

公开(公告)日：2007-02-08

申请号：MXPA06014003

申请日：2005-06-03

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PENDRI YADAGIRI R ,  QIAN XINHUA ,  VEMISHETTI PURUSHOTHAM ,  ZHOU MAOTANG X ,  REIFF EMILY A ,  SINGH AMBARISH K ,  PRASAD SIVA J ,  DHOKTE ULHAS P ,  MOUNTFORD PIA ,  HARTUNG KERRY B ,  SAILES HELEN

IPC: C07D473/18 ,  C07C41/16 ,  C07C41/26 ,  C07C43/178 ,  C07C43/215 ,  C07C43/23 ,  C07D473/10 ,  C07F7/04 ,  C07F7/08 ,  C07F7/18

Abstract: Se describen los procesos para la preparacion del entecavir y los nuevos intermediarios del mismo, utilizando la oxidacion de carbono-silicio (Ver formula I).

公开(公告)号：CA2508811A1

公开(公告)日：2004-06-24

申请号：CA2508811

申请日：2003-12-10

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： KRISHNAMURTY DHILEEPKUMAR ,  THOTTATHIL JOHN ,  PENDRI YADAGIRI R ,  KRONENTHAL DAVID R ,  LEWIS CHARLES ,  POWERS GERALD L ,  PRASAD SIVA JOSYULA ,  VEMISHETTI PURUSHOTHAM ,  SHI ZHONGPING ,  BIEN JEFFREY T ,  ZHOU MAOTANG X ,  PATEL RAMESH N ,  CHEN CHUNG-PIN H ,  LIANG JING ,  RIJHWANI SUSHIL K ,  CHAN YEUNG Y ,  WANG SHAOPENG ,  SINGH AMBARISH K ,  STOJANOVIC MILAN ,  EVANS JEFFREY M ,  PATEL SUNIL S ,  POLNIASZEK RICHARD ,  BANERJEE AMIT ,  KUCERA DAVID J

IPC: C07D473/12 ,  C07D473/18 ,  C07F7/08 ,  C07F7/18

Abstract: Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.

公开(公告)号：PL212790B1

公开(公告)日：2012-11-30

申请号：PL37726303

申请日：2003-12-10

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PENDRI YADAGIRI R ,  CHEN CHUNG-PIN H ,  PATEL SUNIL S ,  EVANS JEFFREY M ,  LIANG JING ,  KRONENTHAL DAVID R ,  POWERS GERALD L ,  PRASAD SIVA JOSYULA ,  BIEN JEFFREY T ,  SHI ZHONGPING ,  PATEL RAMESH N ,  CHAN YEUNG Y ,  RIJHWANI SUSHIL K ,  SINGH AMBARISH K ,  WANG SHAOPENG ,  STOJANOVIC MILAN ,  POLNIASZEK RICHARD ,  LEWIS CHARLES ,  THOTTATHIL JOHN K ,  KRISHNAMURTY DHILEEPKUMAR ,  ZHOU MAOTANG X ,  VEMISHETTI PURUSHOTHAM ,  BANERJEE AMIT ,  KUCERA DAVID J

IPC: C07F7/08 ,  C07D473/12 ,  C07D473/18 ,  C07F7/18

公开(公告)号：PL377263A1

公开(公告)日：2006-01-23

申请号：PL37726303

申请日：2003-12-10

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PENDRI YADAGIRI R ,  CHEN CHUNG-PIN H ,  PATEL SUNIL S ,  EVANS JEFFREY M ,  LIANG JING ,  KRONENTHAL DAVID R ,  POWERS GERALD L ,  PRASAD SIVA JOSYULA ,  BIEN JEFFREY T ,  SHI ZHONGPING ,  PATEL RAMESH N ,  CHAN YEUNG Y ,  RIJHWANI SUSHIL K ,  SINGH AMBARISH K ,  WANG SHAOPENG ,  STOJANOVIC MILAN ,  POLNIASZEK RICHARD ,  LEWIS CHARLES ,  THOTTATHIL JOHN K ,  KRISHNAMURTY DHILEEPKUMAR ,  ZHOU MAOTANG X ,  VEMISHETTI PURUSHOTHAM ,  BANERJEE AMIT ,  KUCERA DAVID J

IPC: C07F7/08 ,  C07D473/12 ,  C07D473/18 ,  C07F7/18

公开(公告)号：CA2569484A1

公开(公告)日：2005-12-15

申请号：CA2569484

申请日：2005-06-03

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： REIFF EMILY A ,  HARTUNG KERRY B ,  PRASAD SIVA J ,  SAILES HELEN ,  DHOKTE ULHAS P ,  ZHOU MAOTANG X ,  QIAN XINHUA ,  VEMISHETTI PURUSHOTHAM ,  PENDRI YADAGIRI R ,  SINGH AMBARISH K ,  MOUNTFORD PIA

IPC: C07D473/18 ,  C07C41/16 ,  C07C41/26 ,  C07C43/178 ,  C07C43/215 ,  C07C43/23 ,  C07D473/10 ,  C07F7/04 ,  C07F7/08 ,  C07F7/18

Abstract: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.