公开(公告)号：EP1131278A4

公开(公告)日：2002-07-24

申请号：EP99958972

申请日：1999-11-16

Applicant: STALEY MFG CO A E

Inventor： COCKREM MICHAEL CHARLES MILNER

IPC: C07C67/08 ,  C07B53/00 ,  C07B61/00 ,  C07C67/54 ,  C07C69/68 ,  C07C67/00 ,  C12P7/00 ,  C12P7/46 ,  C12P7/62

CPC classification number: C07C67/08 ,  C07C69/68

Abstract: A process for producing an ester comprises the steps of: (a) feeding to a first vessel a feed that comprises organic acid, alcohol, and water, whereby organic acid and alcohol react to form monomeric ester and water, and whereby a first liquid effluent is produced that comprises as its components at least some ester, alcohol, and water, the components of the first liquid effluent being substantially in reaction equilibrium; and (b) feeding the first liquid effluent to a second vessel, whereby a vapor product stream and a second liquid effluent stream are produced, the vapour stream comprising ester, alcohol, and water, wherein the second vessel is maintained substantially at vapor-liquid equilibrium but not substantially at reaction equilibrium.

公开(公告)号：EP1173402A4

公开(公告)日：2002-08-14

申请号：EP00926160

申请日：2000-04-19

Applicant: STALEY MFG CO A E

Inventor： COCKREM MICHAEL CHARLES MILNER

IPC: C07C51/41 ,  C07C51/42 ,  C07C67/08 ,  C07C59/08 ,  C07C69/66

CPC classification number: C07C51/42 ,  C07C51/412 ,  C07C67/08 ,  C07C59/08 ,  C07C69/68

Abstract: A process is disclosed for producing an organic acid and optionally for simultaneously producing an ester of the organic acid. The process comprises the steps of: (a) combining an aqueous diluent, an ammonium salt of an organic acid, and an alcohol, thereby forming a homogeneous liquid feed mixture; (b) rapidly heating the feed mixture at a pressure sufficient to suppress at least some vaporization of the alcohol and holding it at a temperature and for a time sufficient to decompose the ammonium salt of the organic acid into ammonia and free organic acid while rapidly removing the ammonia from the reaction-mass transfer equipment, and optionally to react at least some of the free organic acid with the alcohol to form an ester of the organic acid, thereby producing (i) a vapor product stream that comprises ammonia, water, and alcohol, and (ii) a liquid product stream that comprises free organic acid, optionally ester, and alcohol, where of the total quantity of alcohol in the vapor product stream and the liquid product stream, at least about 10 % by weight is present in the liquid product stream; and (c) recovering the free organic acid and optionally the ester from the liquid product stream. The liquid feed mixture can comprise a concentrated crude or partially purified broth produced by a fermentation process.

公开(公告)号：EP1412043A4

公开(公告)日：2004-09-29

申请号：EP02778185

申请日：2002-03-06

Applicant: STALEY MFG CO A E

Inventor： COCKREM MICHAEL CHARLES MILNER ,  KOVACS ISTVAN

IPC: B01D3/36 ,  C07C51/42 ,  C07C51/46 ,  B01D3/10 ,  B01D3/16 ,  B01D3/38 ,  C07C51/48 ,  C07C59/06 ,  C07C59/08 ,  C07C59/10 ,  C07C69/68

CPC classification number: C07C51/46 ,  B01D3/36 ,  C07C51/42 ,  C07C59/06 ,  C07C59/08

Abstract: Cyclic esters of hydroxy organic acids can be produced and recovered via azeotropic distillation. In certain embodiments, cyclic esters such as glycolide and lactide can be produced from a fermentation broth or other feedstream that comprises a hydroxy organic acid, an ammonium salt of a hydroxy organic acid, or an ester of a hydroxy organic acid using azeotropic distillation. The hydroxy organic acid for the feedstream or the organic acid derived from the feedstream by decomposition is related to produce the cyclic ester. In other embodiments a crude composition of a cyclic ester of an organic ester can be purified using azeotropic distillation. The feedstream (10) and an azeotroping agent (12) are mixed in a reactor (14). A first vapor stream (20) can be purified using a first column (22), a second column (27) and a separator (38). A first column bottoms stream (24) from the first column (22) can be recycled back to reactor (14).

公开(公告)号：EP1385593A4

公开(公告)日：2004-08-11

申请号：EP02753604

申请日：2002-03-06

Applicant: STALEY MFG CO A E

Inventor： COCKREM MICHAEL CHARLES MILNER ,  KOVACS ISTVAN

IPC: B01D3/36 ,  C07C51/02 ,  C07C51/06 ,  C07C51/46 ,  C07C231/24 ,  C07C235/06 ,  B01D3/10 ,  B01D3/16 ,  B01D3/38 ,  C07C51/48 ,  C07C59/06 ,  C07C59/08 ,  C07C59/10 ,  C07C69/68

CPC classification number: C07C235/06 ,  B01D3/36 ,  C07C51/02 ,  C07C51/06 ,  C07C51/46 ,  C07C231/24 ,  Y10S516/07 ,  C07C59/08

Abstract: A method for the recovery of an organic acid, such as a heat stable lactic acid, from a feedstream (1) comprising at least one of an organic acid amide, an organic acid ammonium salt or an alkylamine-organic acid complex. The feedstream is mixed with at least one azeotroping agent (2) and the mixture fed to a fractional distillation apparatus or reactor (3). The azeotroping agent is a hydrocarbon capable of forming at least one azeotrope with the organic acid that is produced by the thermal decomposition of the amide, ammonium salt, or complex in the feedstream. The mixture is heated to produce vapor stream (11) that comprises an azeotrope. The vapor stream can be condensed in condenser (12) to a liquid stream, and the organic acid is recovered in the liquid stream that is produced. When the azeotrope is a heteroazeotrope, the vapor stream can be condensed into a liquid stream, which can be separated into a first phase (18) and a second phase (17). The first phase contains the highest concentration of organic acid and the second phase comprises azetroping agent. The organic acid can be further purified and/or concentrated from the separated first phase or form the liquid stream.

Abstract translation: 一种从包含有机酸酰胺，有机酸铵盐或烷基胺 - 有机酸络合物中的至少一种的进料流（1）回收有机酸（例如热稳定乳酸）的方法。 进料流与至少一种共沸剂（2）混合并将混合物进料到分馏装置或反应器（3）。 共沸剂是能够与通过原料流中的酰胺，铵盐或络合物的热分解产生的有机酸形成至少一种共沸物的烃。 加热混合物以产生包含共沸物的蒸气流（11）。 蒸汽流可以在冷凝器（12）中冷凝成液体流，并且将有机酸回收在所产生的液体流中。 当共沸混合物是一种异相共沸混合物时，蒸汽流可以冷凝成液体流，该液流可以分成第一相（18）和第二相（17）。 第一相含有最高浓度的有机酸，第二相含有共沸剂。 有机酸可以从分离的第一相中进一步纯化和/或浓缩或形成液体流。

公开(公告)号：EP1370335A4

公开(公告)日：2004-08-11

申请号：EP02707956

申请日：2002-03-06

Applicant: STALEY MFG CO A E

Inventor： COCKREM MICHAEL CHARLES MILNER ,  KOVACS ISTVAN

IPC: B01D3/36 ,  C07C51/46 ,  C07C231/24 ,  C07C235/06 ,  B01D3/10 ,  B01D3/16 ,  B01D3/38 ,  C07C51/48 ,  C07C59/06 ,  C07C59/08 ,  C07C59/10 ,  C07C69/68

CPC classification number: C07C231/24 ,  B01D3/36 ,  C07C51/46 ,  Y10S203/13 ,  C07C59/08 ,  C07C235/06

Abstract: A method for the recovery of at least one of an organic acid or an organic acid amide, such as heat stable lactic acid or lactamide, from a feedstream (1) including mixing said feedstream that comprises the organic acid and/or organic acid amide with at least one azeotroping agent (2) in reactor (3). The azeotroping agent is a hydrocarbon capable of forming at least one heteroazeotrope with the organic acid or the organic acid amide. The mixture is heated to produce a vapor stream (11) and the vapor stream is further heated to separate components or it can be condensed in condenser (12) into a liquid stream. The liquid stream is capable of being separated into a first phase (18) and a second phase (17). The liquid stream can be further distilled or, alternatively, the two phases of the liquid stream can be separated. The first phase can be separated from the remainder of the liquid stream resulting in recovery of the organic acid and/or organic acid amide. The recovered organic acid and/or organic acid amide can be further purified and/or concentrated from the separated first phase.

公开(公告)号：EP1470099A4

公开(公告)日：2006-04-12

申请号：EP02797276

申请日：2002-12-11

Applicant: STALEY MFG CO A E

Inventor： COCKREM MICHAEL CHARLES MILNER ,  KOVACS ISTVAN ,  MOHAMEDNUR IDRIS ,  HEIDEL DAVID ,  BANIEL AVRAHAM M

IPC: C07C51/48 ,  C07C59/08

CPC classification number: C07C51/48 ,  C07C59/08

Abstract: A process is disclosed for purifying an aqueous feed stream (10) comtaining a product organic acid and a strong contaminant such as another organic acid. The molar concentration of the organic acid in the feed stream (10) is at least 20 times greater than that of the contaminant. The feed stream (10) is contacted with an immiscible basic extractant (18) that has a greater affinity for the contaminant and which complexes with the contaminant and some of the organic acid. The complexed extractant is separated from the aqueous stream (10), so as to produce a first effluent stream (20) comprising product organic acid. The complexed extractant is contacted with a displacing acid, for which the extractant has a greater affinity than contaminant or extractant. As a result, a second effluent stream (28) comprising organic acid and a third effluent stream (30) are produced.

公开(公告)号：BR0208251A

公开(公告)日：2004-03-02

申请号：BR0208251

申请日：2002-03-06

Applicant: STALEY MFG CO A E

Inventor： COCKREM MICHAEL CHARLES MILNER ,  KOVACS ISTVAN

IPC: B01D3/36 ,  C07C51/46 ,  C07C231/24 ,  C07C235/06 ,  B01D3/10 ,  B01D3/16 ,  B01D3/38 ,  C07C51/48 ,  C07C59/06 ,  C07C59/08 ,  C07C59/10 ,  C07C69/68

Abstract: Disclosed herein are methods for the recovery of at least one of an organic acid or an organic acid amide, such as a heat stable lactic acid or lactamide, from a feed stream which contains the organic acid and/or organic acid amide. The feed stream is mixed with at least one azeotroping agent. The azeotroping agent is a hydrocarbon capable of forming at least one heteroazeotrope with the organic acid or the organic acid amide in the feed stream. The mixture of the feed stream and the azeotroping agent is heated to produce a vapor stream. The heteroazeotrope is a component of that vapor stream. The vapor stream can be heated further to separate components or it can be condensed into a liquid stream. The liquid stream is capable of being separated into a first phase and a second phase. The first phase contains the highest concentration of the organic acid and/or the organic acid amide and the azeotroping agent is part of the second phase. The liquid stream can be further distilled or, alternatively, the two phases of the liquid stream can be separated. The first phase can be removed from the remainder of the liquid stream resulting in recovery of the organic acid and/or organic acid amide. The recovered organic acid and/or organic acid amide can be further purified and/or concentrated from the first phase.

公开(公告)号：CA2440987A1

公开(公告)日：2002-09-26

申请号：CA2440987

申请日：2002-03-06

Applicant: STALEY MFG CO A E

Inventor： COCKREM MICHAEL CHARLES MILNER ,  KOVACS ISTVAN

IPC: B01D3/36 ,  C07C51/02 ,  C07C51/06 ,  C07C51/46 ,  C07C231/24 ,  C07C235/06 ,  B01D3/10 ,  C07C59/06 ,  C07C59/08 ,  C07C59/10 ,  B01D3/16 ,  B01D3/38 ,  C07C51/48 ,  C07C69/68

Abstract: A method for the recovery of an organic acid, such as a heat stable lactic acid, from a feedstream (1) comprising at least one of an organic acid amide , an organic acid ammonium salt or an alkylamine-organic acid complex. The feedstream is mixed with at least one azeotroping agent (2) and the mixture fed to a fractional distillation apparatus or reactor (3). The azeotroping agent is a hydrocarbon capable of forming at least one azeotrope with the organic acid that is produced by the thermal decomposition of the amide, ammonium salt, or complex in the feedstream. The mixture is heated to produc e vapor stream (11) that comprises an azeotrope. The vapor stream can be condensed in condenser (12) to a liquid stream, and the organic acid is recovered in the liquid stream that is produced. When the azeotrope is a heteroazeotrope, the vapor stream can be condensed into a liquid stream, whi ch can be separated into a first phase (18) and a second phase (17). The first phase contains the highest concentration of organic acid and the second phas e comprises azetroping agent. The organic acid can be further purified and/or concentrated from the separated first phase or form the liquid stream.

公开(公告)号：AU4473200A

公开(公告)日：2000-11-10

申请号：AU4473200

申请日：2000-04-19

Applicant: STALEY MFG CO A E

Inventor： COCKREM MICHAEL CHARLES MILNER

IPC: C07C51/41 ,  C07C51/42 ,  C07C67/08 ,  C07C59/08 ,  C07C69/66

公开(公告)号：BR0215459A

公开(公告)日：2005-04-05

申请号：BR0215459

申请日：2002-12-11

Applicant: STALEY MFG CO A E

Inventor： COCKREM MICHAEL CHARLES MILNER ,  KOVACS ISTVAN ,  MOHAMEDNUR IDRIS ,  HEIDEL DAVID ,  BANIEL AVRAHAM M

IPC: C07C51/48 ,  C07C59/08