公开(公告)号：DE1470327A1

公开(公告)日：1969-08-07

申请号：DE1470327

申请日：1964-05-08

Applicant: STAMICARBON

Inventor： WILLEM GARRITSEN JOHAN ,  ALBERT BIGOT JOHAN

IPC: C07D201/04 ,  C07D41/06

Abstract: A lactam is prepared by reacting a cycloaliphatic ketoxime hydrochloride with hydrogen chloride at between 50 DEG and 125 DEG C. and decomposing the lactam hydrochloride formed. Alternatively, the oxime hydrochloride may contain more than the equimolecular amount of hydrogen chloride and the reaction carried out without further addition of hydrogen chloride. The reaction may be in a liquid diluent, e.g. a hydrocarbon, or in a non-aqueous solvent in which both the oxime- and lactam-hydrochlorides are soluble. Lactam hydrochloride may be present at the start of the reaction. A catalyst may be used, e.g. phosgene, 1,3,5-trichloro - 5 - triazine, 2,4 - dibromopyrimidine, 2 - chloro - azocycloalkene or 2 - chloroazoalkene. Solvents used are nitro-hydrocarbons, halogenated hydrocarbons and nitriles. Examples refer to the preparation of caprolactam, oenantholactam and caprylolactam.

公开(公告)号：DE1645445A1

公开(公告)日：1970-07-30

申请号：DE1645445

申请日：1965-03-29

Applicant: STAMICARBON

Inventor： ALBERT BIGOT JOHAN ,  MOURIK JOHANNES VAN ,  BEVEREN JOHANNES VAN

IPC: C08G69/20 ,  C08F

公开(公告)号：DE1493197A1

公开(公告)日：1969-02-06

申请号：DE1493197

申请日：1964-10-16

Applicant: STAMICARBON

Inventor： ALBERT BIGOT JOHAN ,  JOHANNES MEYERINK THEO ALBERTU

IPC: C07C51/25 ,  C07D315/00

公开(公告)号：DE1620478A1

公开(公告)日：1970-04-30

申请号：DE1620478

申请日：1965-11-03

Applicant: STAMICARBON

Inventor： WILLEM GARRITSEN JOHAN ,  ALBERT BIGOT JOHAN

IPC: C07D201/04 ,  C07D41/00

Abstract: o -Laurolactam is prepared by reacting cyclododecanone oxime hydrochloride with hydrogen chloride in the presence of a polar organic solvent. Suitable solvents are nitro compounds of hydrocarbons, e.g. nitromethane, nitropropane, nitrobenzene and nitrocyclohexane, halogenated hydrocarbons, e.g. chlorobenzene, chloroform, trichloro-ethylene and isopropyl chloride and nitriles, e.g. acetonitrile, benzonitrile and adiponitrile. The cyclododecanone oxime hydrochloride may contain more than the equimolecular amount of hydrogen chloride, the reaction being carried out with or without further addition of hydrogen chloride. A catalyst may be used, suitable ones being phosgene and halogenated organic nitrogen compounds. The reaction is preferably carried out at between 30 DEG and 125 DEG C.

公开(公告)号：DE1620474A1

公开(公告)日：1970-04-02

申请号：DEST023950

申请日：1965-06-09

Applicant: STAMICARBON

Inventor： ALBERT BIGOT JOHAN ,  LAURENS KERKHOFFS PIETER

IPC: C07D201/10

Abstract: o -Lactams are prepared by reacting cycloalkyl ketones of formula R-CO-R1 where R and R1 are hydrocarbon groups at least one being a cycloalkyl group, with a nitrosating agent in the presence of boron trifluoride. As by-products carboxylic acid derivatives are formed which may be hydrolysed to the acids. A list of suitable nitrosating reagents is given and nitrosyl chloride is exemplified. It is also possible to use a complex of the nitrosating agent and boron trifluoride. When dicycloalkyl ketones are used caprolactam is formed together with a cycloalkyl carboxylic acid which may then react further with the nitrosating reagent to give more caprolactam. The reaction may be carried out in solution, suitably in a saturated hydrocarbon, and is preferably carried out in the presence of water. The examples describe the preparation of capryl lactam from cyclooctyl methyl ketone, and caprolactam from cyclohexyl methyl ketone, using nitrosylchloride.