-
公开(公告)号：DE69636904T2
公开(公告)日：2007-11-15
申请号：DE69636904
申请日：1996-06-06
Applicant: STANFORD RES INST INT
Inventor： BOMBERGER C , CATZ G , SMEDLEY I , STEARNS C
Abstract: Method and system of producing microparticles loaded with biologically active drugs, including proteins such as ICAM-1, for controlled release of the drugs in a nasal passageway. The method includes introducing a drug/polymer feed solution and an emulsifier into a first mixing chamber to create an emulsion, then mixing a cross-linking agent together with the emulsion under controlled conditions to create microparticles loaded with the drug. The system includes a first mixing chamber, in which the emulsion is created, having a first port for introducing the drug/polymer solution, and a second port angled substantially perpendicular to the first port for introducing the emulsifier. A second mixing chamber adjacent to the first mixing chamber receives the emulsion and either contains a cross-linking agent or receives a stream of a cross-linking agent to solidify the microparticles. The formed microparticles are filtered and deaggregated to form individual microparticles that then may be formulated for nasal passageway delivery.
-
公开(公告)号：DE69636904D1
公开(公告)日：2007-03-29
申请号：DE69636904
申请日：1996-06-06
Applicant: STANFORD RES INST INT
Inventor： BOMBERGER C , CATZ G , SMEDLEY I , STEARNS C
Abstract: Method and system of producing microparticles loaded with biologically active drugs, including proteins such as ICAM-1, for controlled release of the drugs in a nasal passageway. The method includes introducing a drug/polymer feed solution and an emulsifier into a first mixing chamber to create an emulsion, then mixing a cross-linking agent together with the emulsion under controlled conditions to create microparticles loaded with the drug. The system includes a first mixing chamber, in which the emulsion is created, having a first port for introducing the drug/polymer solution, and a second port angled substantially perpendicular to the first port for introducing the emulsifier. A second mixing chamber adjacent to the first mixing chamber receives the emulsion and either contains a cross-linking agent or receives a stream of a cross-linking agent to solidify the microparticles. The formed microparticles are filtered and deaggregated to form individual microparticles that then may be formulated for nasal passageway delivery.
-
公开(公告)号：DE69702503T2
公开(公告)日：2001-03-15
申请号：DE69702503
申请日：1997-03-19
Applicant: STANFORD RES INST INT
Inventor： ROSS S , JAYAWEERA INDIRA , BOMBERGER C , LEIF N
IPC: A62D3/00 , A62D3/20 , A62D3/34 , A62D3/35 , A62D3/36 , A62D3/38 , A62D101/02 , A62D101/04 , A62D101/06 , A62D101/22 , A62D101/24 , A62D101/26 , A62D101/28 , A62D101/40 , B01J3/00 , B01J19/00 , B09B3/00 , C02F1/72 , C02F11/08
Abstract: This invention relates to a process for the decomposition of material selected from halogenated organic compounds, to compounds which are environmentally acceptable, or are amenable to further degradation by conventional disposal systems to produce environmentally acceptable products, which process comprises: (a) conveying an aqueous solution or an aqueous slurry of material into a reaction zone capable of withstanding the temperatures and pressures of decomposition of the material; (b)contacting the material in the reaction zone with aqueous sodium carbonate as a reactant in an amount effective to decompose the material under hydrothermal oxidation conditions of between about 300 DEG and 400 DEG C. and a pressure of between about 20 and 400 atmospheres for between 0.01 and 120 min wherein the sodium carbonate at the reaction conditions is present at about 10% or less as a water soluble salt as compared to the solubility of the salt at ambient conditions, wherein the process occurs in the presence of a gaseous oxidant wherein said oxidant is present in an amount of between about 0.01 and 50% by weight of the material; (c) producing about 99% or greater of the decomposition of the material, or 99% or greater conversion of the material to compounds which are environmentally acceptable or to compounds which are amendable to further degradation; and (d) optionally degrading further the compounds produced in step (c) by reaction to environmentally acceptable products. Preferably, the specific reactant is sodium carbonate and the oxidant is oxygen or air. Preferably, the halogenated organic compound is selected from polychlorobiphenyl, polybromobiphenyl or chlorobenzodioxin compounds.
-
公开(公告)号：DE69702503D1
公开(公告)日：2000-08-17
申请号：DE69702503
申请日：1997-03-19
Applicant: STANFORD RES INST INT
Inventor： ROSS S , JAYAWEERA INDIRA , BOMBERGER C , LEIF N
IPC: A62D3/00 , A62D3/20 , A62D3/34 , A62D3/35 , A62D3/36 , A62D3/38 , A62D101/02 , A62D101/04 , A62D101/06 , A62D101/22 , A62D101/24 , A62D101/26 , A62D101/28 , A62D101/40 , B01J3/00 , B01J19/00 , B09B3/00 , C02F1/72 , C02F11/08
Abstract: This invention relates to a process for the decomposition of material selected from halogenated organic compounds, to compounds which are environmentally acceptable, or are amenable to further degradation by conventional disposal systems to produce environmentally acceptable products, which process comprises: (a) conveying an aqueous solution or an aqueous slurry of material into a reaction zone capable of withstanding the temperatures and pressures of decomposition of the material; (b)contacting the material in the reaction zone with aqueous sodium carbonate as a reactant in an amount effective to decompose the material under hydrothermal oxidation conditions of between about 300 DEG and 400 DEG C. and a pressure of between about 20 and 400 atmospheres for between 0.01 and 120 min wherein the sodium carbonate at the reaction conditions is present at about 10% or less as a water soluble salt as compared to the solubility of the salt at ambient conditions, wherein the process occurs in the presence of a gaseous oxidant wherein said oxidant is present in an amount of between about 0.01 and 50% by weight of the material; (c) producing about 99% or greater of the decomposition of the material, or 99% or greater conversion of the material to compounds which are environmentally acceptable or to compounds which are amendable to further degradation; and (d) optionally degrading further the compounds produced in step (c) by reaction to environmentally acceptable products. Preferably, the specific reactant is sodium carbonate and the oxidant is oxygen or air. Preferably, the halogenated organic compound is selected from polychlorobiphenyl, polybromobiphenyl or chlorobenzodioxin compounds.
-
-
-
Search Results
4
records
(took 0.023 seconds)
