公开(公告)号：DE69636904T2

公开(公告)日：2007-11-15

申请号：DE69636904

申请日：1996-06-06

Applicant: STANFORD RES INST INT

Inventor： BOMBERGER C ,  CATZ G ,  SMEDLEY I ,  STEARNS C

IPC: A61K9/14 ,  A61K9/16 ,  A61K38/00 ,  A61K38/17 ,  A61K39/00 ,  B01J2/00

Abstract: Method and system of producing microparticles loaded with biologically active drugs, including proteins such as ICAM-1, for controlled release of the drugs in a nasal passageway. The method includes introducing a drug/polymer feed solution and an emulsifier into a first mixing chamber to create an emulsion, then mixing a cross-linking agent together with the emulsion under controlled conditions to create microparticles loaded with the drug. The system includes a first mixing chamber, in which the emulsion is created, having a first port for introducing the drug/polymer solution, and a second port angled substantially perpendicular to the first port for introducing the emulsifier. A second mixing chamber adjacent to the first mixing chamber receives the emulsion and either contains a cross-linking agent or receives a stream of a cross-linking agent to solidify the microparticles. The formed microparticles are filtered and deaggregated to form individual microparticles that then may be formulated for nasal passageway delivery.

公开(公告)号：DE69636904D1

公开(公告)日：2007-03-29

申请号：DE69636904

申请日：1996-06-06

Applicant: STANFORD RES INST INT

Inventor： BOMBERGER C ,  CATZ G ,  SMEDLEY I ,  STEARNS C

IPC: A61K9/14 ,  A61K9/16 ,  A61K38/00 ,  A61K38/17 ,  A61K39/00 ,  B01J2/00

Abstract: Method and system of producing microparticles loaded with biologically active drugs, including proteins such as ICAM-1, for controlled release of the drugs in a nasal passageway. The method includes introducing a drug/polymer feed solution and an emulsifier into a first mixing chamber to create an emulsion, then mixing a cross-linking agent together with the emulsion under controlled conditions to create microparticles loaded with the drug. The system includes a first mixing chamber, in which the emulsion is created, having a first port for introducing the drug/polymer solution, and a second port angled substantially perpendicular to the first port for introducing the emulsifier. A second mixing chamber adjacent to the first mixing chamber receives the emulsion and either contains a cross-linking agent or receives a stream of a cross-linking agent to solidify the microparticles. The formed microparticles are filtered and deaggregated to form individual microparticles that then may be formulated for nasal passageway delivery.