公开(公告)号：EP0833614A4

公开(公告)日：2001-07-11

申请号：EP96918456

申请日：1996-06-06

Applicant: STANFORD RES INST INT

Inventor： BOMBERGER DAVID C ,  CATZ PAUL G ,  SMEDLEY MARK I ,  STEARNS PAUL C

IPC: A61K9/14 ,  A61K9/16 ,  A61K38/00 ,  A61K38/17 ,  A61K39/00 ,  B01J2/00

CPC classification number: B01J2/00 ,  A61K9/1652 ,  A61K9/1694 ,  A61K38/1774

公开(公告)号：CA2224074A1

公开(公告)日：1996-12-19

申请号：CA2224074

申请日：1996-06-06

Applicant: STANFORD RES INST INT

Inventor： SMEDLEY MARK I ,  STEARNS PAUL C ,  CATZ PAUL G ,  BOMBERGER DAVID C

IPC: A61K9/14 ,  A61K9/16 ,  A61K38/00 ,  A61K38/17 ,  A61K39/00 ,  B01J2/00 ,  A61J3/00 ,  A61K47/36

Abstract: Method and system of producing microparticles loaded with biologically active drugs, including proteins such as ICAM-1, for controlled release of the drugs in a nasal passageway. The method includes introducing a drug/polymer feed solution and an emulsifier into a first mixing chamber to create an emulsion, then mixing a cross-linking agent together with the emulsion under controlled conditions to create microparticles loaded with the drug. The system includes a first mixing chamber, in which the emulsion is created, having a first port for introducing the drug/polymer solution, and a second port angled substantially perpendicular to the first port for introducing the emulsifier. A second mixing chamber adjacent to the first mixing chamber receives the emulsion and either contains a cross-linking agent or receives a stream of a cross-linking agent to solidify the microparticles. The formed microparticles are filtered and deaggregated to form individual microparticles that then may be formulated for nasal passageway delivery.

公开(公告)号：ES2281084T3

公开(公告)日：2007-09-16

申请号：ES96918456

申请日：1996-06-06

Applicant: STANFORD RES INST INT

Inventor： BOMBERGER DAVID C ,  CATZ PAUL G ,  SMEDLEY MARK I ,  STEARNS PAUL C

IPC: A61K9/14 ,  A61K9/16 ,  A61K38/00 ,  A61K38/17 ,  A61K39/00 ,  B01J2/00

Abstract: METODO Y SISTEMA PARA PRODUCIR MICROPARTICULAS CARGADAS CON FARMACOS BIOLOGICAMENTE ACTIVOS, INCLUYENDO PROTEINAS TALES COMO ICAM-1, PARA LA LIBERACION CONTROLADA DE LOS FARMACOS EN LAS FOSAS NASALES. EL METODO INCLUYE LA INTRODUCCION DE UN FARMACO/SOLUCION DE POLIMERO DE ALIMENTACION Y UN EMULSIVO EN UNA PRIMERA CAMARA DE MEZCLA PARA CREAR UNA EMULSION, MEZCLANDO A CONTINUACION UN AGENTE DE ENTRELAZADO JUNTO CON LA EMULSION BAJO CONDICIONES CONTROLADAS PARA CREAR MICROPARTICULAS CARGADAS CON EL FARMACO. EL SISTEMA INCLUYE UNA PRIMERA CAMARA DE MEZCLA, EN LA QUE SE CREA LA EMULSION, QUE POSEE UN PRIMER PUERTO PARA INTRODUCIR EL FARMACO/SOLUCION DE POLIMERO, Y UN SEGUNDO PUERTO EN UN ANGULO PRACTICAMENTE PERPENDICULAR AL PRIMERO PARA INTRODUCIR EL EMULSIVO. UNA SEGUNDA CAMARA DE MEZCLA, ADYACENTE A LA PRIMERA CAMARA, RECIBE LA EMULSION QUE CONTIENE UN AGENTE DE ENTRELAZADO O QUE RECIBE UN CHORRO DE UN AGENTE DE ENTRECRUZAMIENTO PARA SOLIDIFICAR LAS MICROPARTICULAS. LAS MICROPARTICULAS FORMADAS SE FILTRAN Y SE DESAGREGAN PARA FORMAR MICROPARTICULAS INDIVIDUALES QUE PUEDEN ENTONCES SER FORMULADAS PARA SU ADMINISTRACION EN LAS FOSAS NASALES.

公开(公告)号：CA2224074C

公开(公告)日：2009-09-08

申请号：CA2224074

申请日：1996-06-06

Applicant: STANFORD RES INST INT

Inventor： STEARNS PAUL C ,  CATZ PAUL G ,  BOMBERGER DAVID C ,  SMEDLEY MARK I

IPC: A61K9/14 ,  A61K38/17 ,  A61J3/00 ,  A61K9/16 ,  A61K38/00 ,  A61K39/00 ,  A61K47/36 ,  B01J2/00

Abstract: Method and system of producing microparticles loaded with biologically activ e drugs, including proteins such as ICAM-1, for controlled release of the drugs in a nasal passageway. The method includes introducing a drug/polymer feed solution and an emulsifier into a first mixing chamber to create an emulsion, then mixing a cross-linking agent together with the emulsion under controlled conditions to create microparticles loaded with the drug. The system includes a first mixi ng chamber, in which the emulsion is created, having a first port for introducing the drug/polymer solution, and a second port angled substantially perpendicular to the first port for introducing the emulsifier. A second mixing chamber adjacent to the first mixing chamber receives the emulsion and either contains a cross-linking agent or receives a stream of a cross-linking agent to solidify the microparticles . The formed microparticles are filtered and deaggregated to form individual microparticles that then may be formulated for nasal passageway delivery.

公开(公告)号：AT353631T

公开(公告)日：2007-03-15

申请号：AT96918456

申请日：1996-06-06

Applicant: STANFORD RES INST INT

Inventor： BOMBERGER DAVID C ,  CATZ PAUL G ,  SMEDLEY MARK I ,  STEARNS PAUL C

IPC: A61K9/14 ,  A61K9/16 ,  A61K38/00 ,  A61K38/17 ,  A61K39/00 ,  B01J2/00

Abstract: Method and system of producing microparticles loaded with biologically active drugs, including proteins such as ICAM-1, for controlled release of the drugs in a nasal passageway. The method includes introducing a drug/polymer feed solution and an emulsifier into a first mixing chamber to create an emulsion, then mixing a cross-linking agent together with the emulsion under controlled conditions to create microparticles loaded with the drug. The system includes a first mixing chamber, in which the emulsion is created, having a first port for introducing the drug/polymer solution, and a second port angled substantially perpendicular to the first port for introducing the emulsifier. A second mixing chamber adjacent to the first mixing chamber receives the emulsion and either contains a cross-linking agent or receives a stream of a cross-linking agent to solidify the microparticles. The formed microparticles are filtered and deaggregated to form individual microparticles that then may be formulated for nasal passageway delivery.