中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

5 records (took 0.018 seconds)

    INNOVATIVE NANOPORE SEQUENCING TECHNOLOGY
    2.
    发明公开
    INNOVATIVE NANOPORE SEQUENCING TECHNOLOGY 审中-公开
    创新型纳米级定量测定仪

    公开(公告)号：EP3074134A2

    公开(公告)日：2016-10-05

    申请号：EP14865949.3

    申请日：2014-11-26

    Applicant: STC.UNM

    Inventor： BRUECK, Steven, R.J. ,  EDWARDS, Jeremy, Scott ,  NEUMANN, Alexander ,  KUZNETSOVA, Yuliya ,  MENDOZA, Edgar, A.

    IPC: B01L7/00 ,  C12M1/34 ,  C12Q1/68

    Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture “tortuous” nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.

    Abstract translation: 用于长读取，无标记的光学纳米孔长链分子测序的方法和设备。 通常，本公开描述了一种新颖的测序技术，其基于纳米通道的整合以递送具有广泛间隔（>波长），〜1nm孔径“曲折”纳米孔的单个长链分子，其缓慢移位足以提供大量平行的， 使用光学技术的单基准分辨率。 使用简单的胶体纳米颗粒的新型定向自组装纳米加工方案用于在展开长链分子的纳米通道上形成纳米孔阵列。 在纳米颗粒阵列的表面，工程化等离子体/极化结构中的强定位电磁场允许使用光学技术的单碱基分辨率。

    DNA SAMPLE PREPARATION AND SEQUENCING
    3.
    发明申请
    DNA SAMPLE PREPARATION AND SEQUENCING 审中-公开
    DNA样品制备和测序

    公开(公告)号：WO2013049504A1

    公开(公告)日：2013-04-04

    申请号：PCT/US2012/057821

    申请日：2012-09-28

    Applicant: STC.UNM ,  EDWARDS, Jeremy ,  ZARKESH-HA, Payman ,  BRUECK, Steven, R.J.

    Inventor： EDWARDS, Jeremy ,  ZARKESH-HA, Payman ,  BRUECK, Steven, R.J.

    IPC: C12Q1/68 ,  C12N15/10 ,  C12N15/11

    CPC classification number: C12Q1/6869 ,  C12Q1/6806 ,  C12Q1/6874 ,  G01N27/414 ,  G01N27/4145 ,  Y10T436/143333 ,  C12Q2531/125 ,  C12Q2535/122

    Abstract: This disclosure describes, in one aspect, a method for preparing DNA molecule for sequencing. Generally, the method includes fragmenting the DNA molecule into double-stranded fragments; amplifying at least a portion of the double-stranded fragments; circularizing the fragments so that the first end of the fragment comprises a first loop connecting the strands and the second end of the fragment comprises a second loop connecting the strands; annealing a first sequencing primer to the first loop oriented to sequence at least a portion of one strand of the fragment; and annealing a second sequencing primer to the second loop oriented to sequence at least a portion of the other strand of the fragment. In another aspect, this disclosure describes a method for sequencing a DNA molecule. Generally, the method includes fragmenting the DNA molecule into double-stranded fragments; amplifying at least a portion of the double-stranded fragments; circularizing the fragments so that the first end of the fragment comprises a first loop connecting the strands and the second end of the fragment comprises a second loop connecting the strands; and sequencing at least one of the DNA strands.

    Abstract translation: 本公开一方面描述了用于测序的DNA分子的制备方法。 通常，该方法包括将DNA分子分成双链片段; 扩增至少一部分双链片段; 使片段环化，使得片段的第一端包含连接线束的第一环和片段的第二端包括连接线的第二环; 将第一测序引物退火至所述第一环以定向以序列所述片段的一条链的至少一部分; 以及将第二测序引物退火至所述第二环，其定向为序列所述片段的另一条链的至少一部分。 在另一方面，本公开描述了用于测序DNA分子的方法。 通常，该方法包括将DNA分子分成双链片段; 扩增至少一部分双链片段; 使片段环化，使得片段的第一端包含连接线束的第一环和片段的第二端包括连接线的第二环; 并测序至少一个DNA链。

    DOUBLE GATE ION SENSITIVE FIELD EFFECT TRANSISTOR
    5.
    发明申请
    DOUBLE GATE ION SENSITIVE FIELD EFFECT TRANSISTOR 审中-公开
    双栅极离子敏感场效应晶体管

    公开(公告)号：WO2013049463A2

    公开(公告)日：2013-04-04

    申请号：PCT/US2012/057758

    申请日：2012-09-28

    Applicant: STC.UNM ,  ZARKESH-HA, Payman ,  BRUECK, Steven, R.J. ,  EDWARDS, Jeremy

    Inventor： ZARKESH-HA, Payman ,  BRUECK, Steven, R.J. ,  EDWARDS, Jeremy

    CPC classification number: C12Q1/6869 ,  C12Q1/6806 ,  C12Q1/6874 ,  G01N27/414 ,  G01N27/4145 ,  Y10T436/143333 ,  C12Q2531/125 ,  C12Q2535/122

    Abstract: Devices that include a substrate; a source region and a drain region formed within the substrate and having a channel region provided therebetween; a first insulating layer formed over the channel region; a first floating gate formed over the first insulating layer, the first floating gate configured to respond to an analyte in a target material; and a second gate formed over the first floating gate, the second gate capacatively coupled but not electrically connected to the first floating gate.

    Abstract translation:

    包含衬底的器件; 源极区域和漏极区域，形成在所述衬底内并具有设置在其间的沟道区; 形成在沟道区上的第一绝缘层; 形成在所述第一绝缘层上方的第一浮置栅极，所述第一浮置栅极配置为响应靶材料中的分析物; 以及形成在第一浮置栅极之上的第二栅极，第二栅极电容耦合但不电连接到第一浮置栅极。

Patent Agency Ranking