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    SYNTHETIC LONG READ DNA SEQUENCING
    2.
    发明申请
    SYNTHETIC LONG READ DNA SEQUENCING 审中-公开
    合成长读DNA序列

    公开(公告)号：WO2015053943A1

    公开(公告)日：2015-04-16

    申请号：PCT/US2014/057260

    申请日：2014-09-24

    Applicant: STC.UNM ,  EDWARDS, Jeremy, Scott

    Inventor： EDWARDS, Jeremy, Scott

    IPC: C12Q1/68

    CPC classification number: C12Q1/689 ,  C12Q1/6853 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2525/161 ,  C12Q2525/179 ,  C12Q2563/179

    Abstract: The disclosure describes a method for sequencing long portions of DNA sequence by assembling a plurality of shorter polynucleotide reads. Generally, The method includes annealing a plurality of primers to a denatured DNA molecule, appending a barcode polynucleotide to the 5' end of the primer, subjecting the DNA molecules to a plurality of cycles of (1) pooling, (2) dividing, and (3) appending a barcode polynucleotide to the 5' end of the primer, sequencing the barcode polynucleotides and the genomic DNA, and assembling the short read polynucleotide sequences having identical barcode polynucleotides.

    Abstract translation: 本公开描述了通过组装多个较短的多核苷酸读取来测序DNA序列的长部分的方法。 通常，该方法包括将多个引物退火至变性DNA分子，将条形码多核苷酸附加到引物的5'末端，对DNA分子进行多个循环（1）合并，（2）分裂和 （3）将条形码多核苷酸添加到引物的5'末端，对条形码多核苷酸和基因组DNA进行测序，并组装具有相同条形码多核苷酸的短读多核苷酸序列。

    INNOVATIVE NANOPORE SEQUENCING TECHNOLOGY
    5.
    发明公开
    INNOVATIVE NANOPORE SEQUENCING TECHNOLOGY 审中-公开
    创新型纳米级定量测定仪

    公开(公告)号：EP3074134A2

    公开(公告)日：2016-10-05

    申请号：EP14865949.3

    申请日：2014-11-26

    Applicant: STC.UNM

    Inventor： BRUECK, Steven, R.J. ,  EDWARDS, Jeremy, Scott ,  NEUMANN, Alexander ,  KUZNETSOVA, Yuliya ,  MENDOZA, Edgar, A.

    IPC: B01L7/00 ,  C12M1/34 ,  C12Q1/68

    Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture “tortuous” nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.

    Abstract translation: 用于长读取，无标记的光学纳米孔长链分子测序的方法和设备。 通常，本公开描述了一种新颖的测序技术，其基于纳米通道的整合以递送具有广泛间隔（>波长），〜1nm孔径“曲折”纳米孔的单个长链分子，其缓慢移位足以提供大量平行的， 使用光学技术的单基准分辨率。 使用简单的胶体纳米颗粒的新型定向自组装纳米加工方案用于在展开长链分子的纳米通道上形成纳米孔阵列。 在纳米颗粒阵列的表面，工程化等离子体/极化结构中的强定位电磁场允许使用光学技术的单碱基分辨率。

    DNA SEQUENCING AND EPIGENOME ANALYSIS
    6.
    发明公开
    DNA SEQUENCING AND EPIGENOME ANALYSIS 有权
    DNA测序和核酸分析

    公开(公告)号：EP3027775A1

    公开(公告)日：2016-06-08

    申请号：EP14832389.2

    申请日：2014-08-01

    Applicant: STC.UNM ,  Edwards, Jeremy, Scott

    Inventor： EDWARDS, Jeremy, Scott

    IPC: C12Q1/68

    CPC classification number: C12Q1/6874 ,  C12Q1/6825 ,  C12Q1/6841 ,  C12Q2523/303 ,  C12Q2543/10 ,  C12Q2523/307

    Abstract: This disclosure describes, in one aspect, methods for DNA sequencing and performing epigenomic analyses. Generally, the methods include immobilizing a plurality of copies of a DNA molecule on a surface, stretching at least a portion of the immobilized DNA molecules, and sequencing at least a portion of the immobilized, stretched DNA molecules.

    Abstract translation: 在一个方面，本公开描述了用于DNA测序和进行表观基因组分析的方法。 通常，这些方法包括将多个DNA分子拷贝固定在表面上，拉伸至少一部分固定的DNA分子，并对至少一部分固定的，拉伸的DNA分子进行测序。

    DNA SEQUENCING AND EPIGENOME ANALYSIS
    8.
    发明申请
    DNA SEQUENCING AND EPIGENOME ANALYSIS 审中-公开
    DNA序列和分析

    公开(公告)号：WO2015017759A1

    公开(公告)日：2015-02-05

    申请号：PCT/US2014/049372

    申请日：2014-08-01

    Applicant: STC.UNM ,  EDWARDS, Jeremy, Scott

    Inventor： EDWARDS, Jeremy, Scott

    IPC: C12Q1/68

    CPC classification number: C12Q1/6874 ,  C12Q1/6825 ,  C12Q1/6841 ,  C12Q2523/303 ,  C12Q2543/10 ,  C12Q2523/307

    Abstract: This disclosure describes, in one aspect, methods for DNA sequencing and performing epigenomic analyses. Generally, the methods include immobilizing a plurality of copies of a DNA molecule on a surface, stretching at least a portion of the immobilized DNA molecules, and sequencing at least a portion of the immobilized, stretched DNA molecules.

    Abstract translation: 本公开在一个方面描述了用于DNA测序和进行表观基因组分析的方法。 通常，所述方法包括将多个拷贝的DNA分子固定在表面上，拉伸固定的DNA分子的至少一部分，以及测序至少一部分固定的，拉伸的DNA分子。

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