公开(公告)号：EP3074134B1

公开(公告)日：2020-03-18

申请号：EP14865949.3

申请日：2014-11-26

Applicant: STC.UNM

Inventor： BRUECK, Steven, R.J. ,  EDWARDS, Jeremy, Scott ,  NEUMANN, Alexander ,  KUZNETSOVA, Yuliya ,  MENDOZA, Edgar, A.

IPC: B01L7/00 ,  C12M1/34 ,  C12Q1/68 ,  G01N33/487

公开(公告)号：EP3152788A1

公开(公告)日：2017-04-12

申请号：EP15807428.6

申请日：2015-06-09

Applicant: Stc.Unm

Inventor： BRUECK, Steven, R., J. ,  NEUMANN, Alexander ,  ZARKESH-HA, Payman

IPC: H01L33/58 ,  H01L33/48 ,  F21S2/00

CPC classification number: G01J1/06 ,  G01J1/44 ,  G01J3/0218 ,  G01J3/0259 ,  G01J3/18 ,  G01J3/1895 ,  G01J3/2803 ,  G01J2001/448 ,  G02B6/00 ,  G02B6/10 ,  G02B6/12004 ,  G02B6/122 ,  G02B6/124 ,  H01L27/1446 ,  H01L31/02019 ,  H01L31/02164 ,  H01L31/02327 ,  H01L31/103

Abstract: A 2-D sensor array includes a semiconductor substrate and a plurality of pixels disposed on the semiconductor substrate. Each pixel includes a coupling region and a junction region, and a slab waveguide structure disposed on the semiconductor substrate and extending from the coupling region to the region. The slab waveguide includes a confinement layer disposed between a first cladding layer and a second cladding layer. The first cladding and the second cladding each have a refractive index that is lower than a refractive index of the confinement layer. Each pixel also includes a coupling structure disposed in the coupling region and within the slab waveguide. The coupling structure includes two materials having different indices of refraction arranged as a grating defined by a grating period. The junction region comprises a p-n junction in communication with electrical contacts for biasing and collection of carriers resulting from absorption of incident radiation.

Abstract translation: 2维传感器阵列包括半导体衬底和设置在半导体衬底上的多个像素。 每个像素包括耦合区域和结区域，以及设置在半导体衬底上并从耦合区域延伸到该区域的平板波导结构。 平板波导包括设置在第一包层和第二包层之间的限制层。 第一包层和第二包层各自具有低于限制层的折射率的折射率。 每个像素还包括设置在耦合区域中并且在平板波导内的耦合结构。 耦合结构包括具有不同的折射率布置为由光栅周期限定的光栅的两种材料。 结区域包括与电触点连通的p-n结，用于偏移和收集由吸收入射辐射引起的载流子。

公开(公告)号：WO2015191557A1

公开(公告)日：2015-12-17

申请号：PCT/US2015/034868

申请日：2015-06-09

Applicant: STC.UNM

Inventor： BRUECK, Steven, R., J. ,  NEUMANN, Alexander ,  ZARKESH-HA, Payman

IPC: H01L33/58 ,  H01L33/48 ,  F21S2/00

CPC classification number: G01J1/06 ,  G01J1/44 ,  G01J3/0218 ,  G01J3/0259 ,  G01J3/18 ,  G01J3/1895 ,  G01J3/2803 ,  G01J2001/448 ,  G02B6/00 ,  G02B6/10 ,  G02B6/12004 ,  G02B6/122 ,  G02B6/124 ,  H01L27/1446 ,  H01L31/02019 ,  H01L31/02164 ,  H01L31/02327 ,  H01L31/103

Abstract: A 2-D sensor array includes a semiconductor substrate and a plurality of pixels disposed on the semiconductor substrate. Each pixel includes a coupling region and a junction region, and a slab waveguide structure disposed on the semiconductor substrate and extending from the coupling region to the region. The slab waveguide includes a confinement layer disposed between a first cladding layer and a second cladding layer. The first cladding and the second cladding each have a refractive index that is lower than a refractive index of the confinement layer. Each pixel also includes a coupling structure disposed in the coupling region and within the slab waveguide. The coupling structure includes two materials having different indices of refraction arranged as a grating defined by a grating period. The junction region comprises a p-n junction in communication with electrical contacts for biasing and collection of carriers resulting from absorption of incident radiation.

Abstract translation: 2维传感器阵列包括半导体衬底和设置在半导体衬底上的多个像素。 每个像素包括耦合区域和结区域，以及设置在半导体衬底上并从耦合区域延伸到该区域的平板波导结构。 平板波导包括设置在第一包层和第二包层之间的限制层。 第一包层和第二包层各自具有低于限制层的折射率的折射率。 每个像素还包括设置在耦合区域中并且在平板波导内的耦合结构。 耦合结构包括具有不同折射率的两种材料，其布置为由光栅周期限定的光栅。 结区域包括与电触点连通的p-n结，用于偏移和收集由吸收入射辐射引起的载流子。

公开(公告)号：EP3074134A2

公开(公告)日：2016-10-05

申请号：EP14865949.3

申请日：2014-11-26

Applicant: STC.UNM

Inventor： BRUECK, Steven, R.J. ,  EDWARDS, Jeremy, Scott ,  NEUMANN, Alexander ,  KUZNETSOVA, Yuliya ,  MENDOZA, Edgar, A.

IPC: B01L7/00 ,  C12M1/34 ,  C12Q1/68

Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture “tortuous” nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.

Abstract translation: 用于长读取，无标记的光学纳米孔长链分子测序的方法和设备。 通常，本公开描述了一种新颖的测序技术，其基于纳米通道的整合以递送具有广泛间隔（>波长），〜1nm孔径“曲折”纳米孔的单个长链分子，其缓慢移位足以提供大量平行的， 使用光学技术的单基准分辨率。 使用简单的胶体纳米颗粒的新型定向自组装纳米加工方案用于在展开长链分子的纳米通道上形成纳米孔阵列。 在纳米颗粒阵列的表面，工程化等离子体/极化结构中的强定位电磁场允许使用光学技术的单碱基分辨率。

公开(公告)号：WO2015081294A9

公开(公告)日：2015-06-04

申请号：PCT/US2014/067764

申请日：2014-11-26

Applicant: STC.UNM ,  BRUECK, Steven, R.J. ,  EDWARDS, Jeremy, Scott ,  NEUMANN, Alexander ,  KUZNETSOVA, Yuliya ,  MENDOZA, Edgar, A.

Inventor： BRUECK, Steven, R.J. ,  EDWARDS, Jeremy, Scott ,  NEUMANN, Alexander ,  KUZNETSOVA, Yuliya ,  MENDOZA, Edgar, A.

IPC: B01L7/00 ,  C12M1/34 ,  C12Q1/68

Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (> wavelength), ~ 1-nm aperture "tortuous" nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.