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Patent Agency Ranking1.发明申请RECOMBINANT CLASSICAL SWINE FEVER VIRUS (CSFV) COMPRISING A MODIFIED E2 PROTEIN AND METHODS FOR GENERATING SAID RECOMBINANT CSFV. 审中-公开包含修饰的E2蛋白的重组经典开关病毒（CSFV）和用于产生上述重组体CSFV的方法。
公开(公告)号：WO2010074575A2
公开(公告)日：2010-07-01
申请号：PCT/NL2009/050801
申请日：2009-12-23
Applicant: STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK , KORTEKAAS, Jeroen Alexander , VLOET, Rianka Petronella Maria
IPC: C12N7/04 , C07K14/18 , A61K39/12 , G01N33/569
CPC classification number: C12N7/00 , C07K14/005 , C12N2770/24322 , C12N2770/24361 , G01N33/56983
Abstract: The invention relates to a recombinant classical swine fever virus (CSFV). A preferred recombinant CSFV comprises a deletion of at least one amino acid in a "TAVSPTTLR" domain of the E2 protein. The invention further relates to a vaccine comprising the recombinant CSFV, a method for generating a recombinant CSFV, and use of a recombinant CSFV.
Abstract translation: 本发明涉及重组典型猪瘟病毒（CSFV）。 优选的重组CSFV包含E2蛋白的“TAVSPTTLR”结构域中至少一个氨基酸的缺失。 本发明还涉及包含重组CSFV的疫苗，产生重组CSFV的方法和重组CSFV的使用。
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2.发明申请BUNYAVIRUSES WITH SEGMENTED GLYCOPROTEIN PRECURSOR GENES AND METHODS FOR GENERATING THESE VIRUSES 审中-公开具有分离的GLYCOPROTEIN前体基因的芽孢杆菌和产生这些病毒的方法
公开(公告)号：WO2014189372A1
公开(公告)日：2014-11-27
申请号：PCT/NL2014/050321
申请日：2014-05-21
Applicant: STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK
Inventor： KORTEKAAS, Jeroen Alexander , WICHGERS SCHREUR, Paulus-Jozef , ORESHKOVA, Nadia Dimitrova , MOORMANN, Robertus Jacobus Maria
IPC: C12N7/00
CPC classification number: A61K39/12 , A61K2039/525 , C12N7/00 , C12N2760/12034 , C12N2760/12221 , C12N2760/12234 , C12N2760/12243 , C12N2760/12262
Abstract: Title: Bunyaviruses with segmented glycoprotein precursor genes and methods for generating these viruses Abstract: The invention relates to a bunyavirus, in which separated (NSm)Gn and Gc coding regions are functionally present on two different genome segments, preferably a bunyavirus that comprises a total of at least 4 genome segments. The invention further relates to methods for producing said bunyavirus, and to a composition comprising said bunyavirus and a suitable excipient.
Abstract translation: 标题：具有分段糖蛋白前体基因的布尼亚病毒和产生这些病毒的方法摘要：本发明涉及一种布尼亚病毒，其中分离的（NSm）Gn和Gc编码区功能上存在于两个不同的基因组片段上，优选布尼亚病毒，其包含总数 至少4个基因组片段。 本发明还涉及用于生产所述布尼亚病毒的方法，以及包含所述布尼亚病毒和合适赋形剂的组合物。
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3.发明申请USE OF NEWCASTLE DISEASE VIRUS-BASED VECTOR FOR INDUCING AN IMMUNE RESPONSE IN MAMMALS 审中-公开使用基于病毒的基于病毒的矢量来诱导哺乳动物的免疫反应
公开(公告)号：WO2011059334A1
公开(公告)日：2011-05-19
申请号：PCT/NL2010/050763
申请日：2010-11-16
Applicant: STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK , MOORMANN, Robertus Jacobus Maria , KORTEKAAS, Jeroen Alexander , ANTONIS, Adrianus Franciscus Gerardus , PEETERS, Bernardus Petrus Hubertus , DEKKER, Aldo
Inventor： MOORMANN, Robertus Jacobus Maria , KORTEKAAS, Jeroen Alexander , ANTONIS, Adrianus Franciscus Gerardus , PEETERS, Bernardus Petrus Hubertus , DEKKER, Aldo
CPC classification number: C12N15/86 , A61K39/12 , A61K39/17 , A61K48/0075 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/54 , A61K2039/543 , C12N2760/12234 , C12N2760/18134 , C12N2760/18143 , A61K2300/00
Abstract: The invention relates to methods of stimulating an immune response against an antigenic protein in a mammalian subject. More specifically, the invention relates to routes of administration of a hybrid Newcastle Disease Virus-vector (NDV-vector) for eliciting an immune response against an antigenic protein that is encoded by the hybrid NDV-vector.
Abstract translation: 本发明涉及在哺乳动物受试者中刺激针对抗原蛋白的免疫应答的方法。 更具体地，本发明涉及用于引发针对由混合NDV载体编码的抗原性蛋白的免疫应答的混合新城疫病毒载体（NDV-载体）的给药途径。
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4.发明公开BUNYAVIRUSES WITH SEGMENTED GLYCOPROTEIN PRECURSOR GENES AND METHODS FOR GENERATING THESE VIRUSES 有权BUNYAVIREN MIT SEGMENTIGTENGLYCOPROTEINVORLÄUFERGENENUND VERFAHREN ZUR ERZEUGUNG DIESER VIREN
公开(公告)号：EP2999781A1
公开(公告)日：2016-03-30
申请号：EP14729458.1
申请日：2014-05-21
Applicant: Stichting Dienst Landbouwkundig Onderzoek
Inventor： KORTEKAAS, Jeroen Alexander , WICHGERS SCHREUR, Paulus-Jozef , ORESHKOVA, Nadia Dimitrova , MOORMANN, Robertus Jacobus Maria
IPC: C12N7/00
CPC classification number: A61K39/12 , A61K2039/525 , C12N7/00 , C12N2760/12034 , C12N2760/12221 , C12N2760/12234 , C12N2760/12243 , C12N2760/12262
Abstract: The invention relates to a bunyavirus, in which separated (NSm)Gn and Gc coding regions are functionally present on two different genome segments, preferably a bunyavirus that comprises a total of at least 4 genome segments. The invention further relates to methods for producing said bunyavirus, and to a composition comprising said bunyavirus and a suitable excipient.
Abstract translation: 本发明涉及布尼亚病毒，其中分离的（NSm）Gn和Gc编码区功能性地存在于两个不同的基因组片段上，优选包含总共至少4个基因组片段的布尼亚病毒。 本发明还涉及用于生产所述布尼亚病毒的方法，以及包含所述布尼亚病毒和合适赋形剂的组合物。
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5.发明公开USE OF NEWCASTLE DISEASE VIRUS-BASED VECTOR FOR INDUCING AN IMMUNE RESPONSE IN MAMMALS 审中-公开对非典型AVIAN基于向量的用于在哺乳动物中诱导免疫应答
公开(公告)号：EP2501404A1
公开(公告)日：2012-09-26
申请号：EP10787565.0
申请日：2010-11-16
Applicant: Stichting Dienst Landbouwkundig Onderzoek
Inventor： MOORMANN, Robertus Jacobus Maria , KORTEKAAS, Jeroen Alexander , ANTONIS, Adrianus Franciscus Gerardus , PEETERS, Bernardus Petrus Hubertus , DEKKER, Aldo
CPC classification number: C12N15/86 , A61K39/12 , A61K39/17 , A61K48/0075 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/54 , A61K2039/543 , C12N2760/12234 , C12N2760/18134 , C12N2760/18143 , A61K2300/00
Abstract: The invention relates to methods of stimulating an immune response against an antigenic protein in a mammalian subject. More specifically, the invention relates to routes of administration of a hybrid Newcastle Disease Virus-vector (NDV-vector) for eliciting an immune response against an antigenic protein that is encoded by the hybrid NDV-vector.
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