公开(公告)号：NL1008139C2

公开(公告)日：1999-07-28

申请号：NL1008139

申请日：1998-01-27

Applicant: STICHTING TECH WETENSCHAPP

Inventor： AMERONGEN ARIE VAN NIEUW ,  VEERMAN ENGELMUNDUS CORNELIS I ,  HOF WILLEM VAN T ,  HELMERHORST EVA JOHANNA

IPC: A61K9/06 ,  A61K9/12 ,  A61K38/00 ,  A61P31/04 ,  A61P31/10 ,  C07K7/08 ,  C07K14/47 ,  A61K38/10 ,  A61K38/17

公开(公告)号：NL1010692C2

公开(公告)日：2000-06-06

申请号：NL1010692

申请日：1998-12-01

Applicant: STICHTING TECH WETENSCHAPP

Inventor： AMERONGEN ARIE VAN NIEUW ,  VEERMAN ENGELMUNDUS CORNELIS I ,  HOF WILLEM VAN T ,  NIBBERING PETER HENDRICUS

IPC: A61K38/00 ,  C07K7/08 ,  C07K14/47 ,  A61K38/10 ,  A61K38/17

Abstract: The invention relates to peptides for use as antiviral agent, consisting of an amino acid chain which contains a domain of 10 to 25 amino acids, wherein the majority of the amino acids of the one half of the domain are positively charged amino acids and the majority of the amino acids of the other half of the domain are uncharged amino acids. The invention further relates to oligomers of these peptides consisting of at least two such peptides which are coupled to each other, optionally via a spacer, for use as antiviral agent, in addition to the use of the peptides and/or oligomers for the manufacture of a medicine for treating viral infections.

公开(公告)号：NL1008745C2

公开(公告)日：1999-10-01

申请号：NL1008745

申请日：1998-03-30

Applicant: STICHTING TECH WETENSCHAPP

Inventor： AMERONGEN ARIE VAN NIEUW ,  VEERMAN ENGELMUNDUS CORNELIS I ,  HOF WILLEM VAN T ,  REIJDEN WILLY ALEXANDER VAN DE ,  RUISSEN ANNETJE LENA ADRIANA

IPC: A61K38/00 ,  A61K47/48 ,  C07K14/47 ,  C07K7/00

Abstract: Conjugates of an antifungal peptide and a mucoadhesive polymer are new. The peptide has a domain of 10 - 25 amino acids in which most of the amino acids in one half of the domain are positively charged amino acids and most of the amino acids in the other half of the domain are uncharged amino acids.