公开(公告)号：WO0032629A3

公开(公告)日：2000-08-17

申请号：PCT/NL9900732

申请日：1999-12-01

Applicant: STICHTING TECH WETENSCHAPP ,  NIEUW AMERONGEN ARIE VAN ,  VEERMAN ENGELMUNDUS CORNELIS I ,  T HOF WILLEM VAN ,  NIBBERING PETER HENDRICUS

Inventor： VAN NIEUW AMERONGEN ARIE ,  VEERMAN ENGELMUNDUS CORNELIS I ,  VAN T HOF WILLEM ,  NIBBERING PETER HENDRICUS

IPC: A61K38/00 ,  C07K7/08 ,  C07K14/47 ,  A61K38/10 ,  A61K38/17 ,  A61P31/12 ,  A61P31/18

CPC classification number: C07K7/08 ,  A61K38/00 ,  C07K14/4723

Abstract: The invention relates to peptides for use as antiviral agent, consisting of an amino acid chain which contains a domain of 10 to 25 amino acids, wherein the majority of the amino acids of the one half of the domain are positively charged amino acids and the majority of the amino acids of the other half of the domain are uncharged amino acids. The invention further relates to oligomers of these peptides consisting of at least two such peptides which are coupled to each other, optionally via a spacer, for use as antiviral agent, in addition to the use of the peptides and/or oligomers for the manufacture of a medicine for treating viral infections.

Abstract translation: 本发明涉及用作抗病毒剂的肽，其由包含10至25个氨基酸的结构域的氨基酸链组成，其中该域的一半的大部分氨基酸是带正电荷的氨基酸，并且多数 的另一半结构域的氨基酸是不带电荷的氨基酸。 本发明还涉及由至少两种这样的肽组成的这些肽的寡聚体，除了使用肽和/或低聚物以外，还可以任选经由间隔物彼此偶联，用作抗病毒剂。 用于治疗病毒感染的药物。

公开(公告)号：WO9937678A3

公开(公告)日：1999-10-14

申请号：PCT/NL9900045

申请日：1999-01-26

Applicant: STICHTING TECH WETENSCHAPP ,  NIEUW AMERONGEN ARIE VAN ,  VEERMAN ENGELMUNDUS CORNELIS I ,  T HOF WILLEM VAN ,  HELMERHORST EVA JOSEPHINE

Inventor： VAN NIEUW AMERONGEN ARIE ,  VEERMAN ENGELMUNDUS CORNELIS I ,  VAN T HOF WILLEM ,  HELMERHORST EVA JOSEPHINE

IPC: A61K9/06 ,  A61K9/12 ,  A61K38/00 ,  A61P31/04 ,  A61P31/10 ,  C07K7/08 ,  C07K14/47 ,  A61K38/10 ,  A61K38/17

CPC classification number: C07K7/08 ,  A61K38/00 ,  C07K14/4723

Abstract: The invention relates to peptides with antimicrobial activity, consisting of an amino acid chain which contains a domain of 10 to 25 amino acids, wherein the majority of the amino acids of the one half of the domain are positively charged amino acids and the majority of the amino acids of the other half of the domain are uncharged amino acids.

Abstract translation: 本发明涉及具有抗微生物活性的肽，其由含有10至25个氨基酸的结构域的氨基酸链组成，其中结构域的一半的大部分氨基酸为带正电荷的氨基酸，并且大部分 另一半结构域的氨基酸是不带电荷的氨基酸。

公开(公告)号：CA2319094A1

公开(公告)日：1999-07-29

申请号：CA2319094

申请日：1999-01-26

Applicant: STICHTING TECH WETENSCHAPP

Inventor： HELMERHORST EVA JOSEPHINE ,  VAN T HOF WILLEM ,  VEERMAN ENGELMUNDUS CORNELIS I ,  VAN NIEUW AMERONGEN ARIE

IPC: A61K9/06 ,  A61K9/12 ,  A61K38/00 ,  A61P31/04 ,  A61P31/10 ,  C07K7/08 ,  C07K14/47 ,  A61K38/10 ,  A61K38/17

Abstract: The invention relates to peptides with antimicrobial activity, consisting of an amino acid chain which contains a domain of 10 to 25 amino acids, wherein the majority of the amino acids of the one half of the domain are positively charged amino acids and the majority of the amino acids of the other half of the domain are uncharged amino acids.

公开(公告)号：CA2319094C

公开(公告)日：2009-03-17

申请号：CA2319094

申请日：1999-01-26

Applicant: STICHTING TECH WETENSCHAPP

Inventor： VAN NIEUW AMERONGEN ARIE ,  VEERMAN ENGELMUNDUS CORNELIS IGNATIUS ,  VAN T HOF WILLEM ,  HELMERHORST EVA JOSEPHINE

IPC: A61K9/06 ,  C07K14/47 ,  A61K9/12 ,  A61K38/00 ,  A61K38/10 ,  A61K38/17 ,  A61P31/04 ,  A61P31/10 ,  C07K7/08

Abstract: The invention relates to peptides with antimicrobial activity, consisting of an amino acid chain which contains a domain of 10 to 25 amino acids, wherein the majority of the amino acids of the one half of the domain are positively charged amino acids and the majority of the amino acids of the other half of the domain are uncharged amino acids.