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公开(公告)号：WO2016135754A1
公开(公告)日：2016-09-01
申请号：PCT/IN2016/050068
申请日：2016-02-25
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD
Inventor： BOMMAGANI, Madhusudhan , BHOWMICK, Subhas Balaram , KANE, Prashant , DUBEY, Vaibhav
CPC classification number: A61K9/146 , A61K9/0014 , A61K9/06 , A61K9/10 , A61K9/122 , A61K31/65 , A61K47/14 , Y02A50/473
Abstract: The present invention relates to a nanoparticulate topical composition comprising (i) nanoparticles of a water soluble and water susceptible active ingredient or its pharmaceutically acceptable salt, having a particle size distribution such that 90% of the particles are less than 1000 nm, (ii) one or more wetting agent and (iii) a non-aqueous liquid vehicle, wherein the composition is free of water. The present invention also relates to a method of treating acne, rosacea, impetigo or a skin disease caused by a bacteria, by topical application of a nanoparticulate topical composition comprising nanoparticles of a water soluble and water susceptible active ingredient or its pharmaceutically acceptable salt, having a particle size distribution such that 90% of the particles are less than 1000 nm.
Abstract translation: 本发明涉及纳米颗粒局部组合物，其包含（i）水溶性和水易感活性成分或其药学上可接受的盐的纳米颗粒，其粒度分布使得90％的颗粒小于1000nm，（ii） 一种或多种润湿剂和（iii）非水液体载体，其中所述组合物不含水。 本发明还涉及通过局部施用包含水溶性和水敏感活性成分或其药学上可接受的盐的纳米颗粒的纳米颗粒局部组合物来治疗由细菌引起的痤疮，红斑痤疮，脓疱病或皮肤病的方法，其具有 使得90％的颗粒小于1000nm的粒度分布。
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公开(公告)号：WO2016135753A1
公开(公告)日：2016-09-01
申请号：PCT/IN2016/050067
申请日：2016-02-25
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.
Inventor： BOMMAGANI, Madhusudhan , BHOWMICK, Subhas Balaram , KANE, Prashant , DUBEY, Vaibhav
Abstract: The present invention relates to a method of preparing a nanoparticulate topical composition of a water soluble, water-susceptible active ingredient or its pharmaceutically acceptable salt, the method comprising steps of milling the water soluble, water-susceptible active ingredient or its salt, a wetting agent and a non-aqueous liquid vehicle to obtain a non-aqueous nanosuspension and converting the non-aqueous nanosuspension into a topical composition.
Abstract translation: 本发明涉及一种制备水溶性，水敏感性活性成分或其药学上可接受的盐的纳米颗粒局部组合物的方法，所述方法包括以下步骤：研磨水溶性，水敏感的活性成分或其盐，润湿 试剂和非水液体载体以获得非水性纳米悬浮液并将非水性纳米悬浮液转化成局部组合物。
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公开(公告)号：EP3261618A1
公开(公告)日：2018-01-03
申请号：EP16754874.2
申请日：2016-02-25
Applicant: Sun Pharma Advanced Research Company Ltd
Inventor： BOMMAGANI, Madhusudhan , BHOWMICK, Subhas Balaram , KANE, Prashant , DUBEY, Vaibhav
CPC classification number: A61K31/65 , A61K9/0014 , A61K9/06 , A61K9/10 , A61K9/122 , A61K9/143 , A61K9/146
Abstract: The present invention relates to a method of preparing a nanoparticulate topical composition of a water soluble, water-susceptible active ingredient or its pharmaceutically acceptable salt, the method comprising steps of milling the water soluble, water-susceptible active ingredient or its salt, a wetting agent and a non-aqueous liquid vehicle to obtain a non-aqueous nanosuspension and converting the non-aqueous nanosuspension into a topical composition.
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公开(公告)号：EP3261619A1
公开(公告)日：2018-01-03
申请号：EP16754875.9
申请日：2016-02-25
Applicant: Sun Pharma Advanced Research Company Ltd
Inventor： BOMMAGANI, Madhusudhan , BHOWMICK, Subhas Balaram , KANE, Prashant , DUBEY, Vaibhav
CPC classification number: A61K9/146 , A61K9/0014 , A61K9/06 , A61K9/10 , A61K9/122 , A61K31/65 , A61K47/14 , Y02A50/473
Abstract: The present invention also relates to a method of treating acne, rosacea, impetigo or a skin disease caused by a bacteria, by topical application of a nanoparticulate topical composition comprising nanoparticles of a water soluble and water susceptible active ingredient or its pharmaceutically acceptable salt, having a particle size distribution such that 90% of the particles are less than 1000 nm.
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