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公开(公告)号：EP3247397A4
公开(公告)日：2018-06-20
申请号：EP16739852
申请日：2016-01-19
Applicant: THERALASE TECH INC
Inventor： MANDEL ARKADY
IPC: A61K41/00 , A61K31/498 , A61K33/24 , A61K38/40 , A61P31/00 , A61P35/00 , C07D213/04 , C07D215/02 , C07D239/24 , C07D401/14 , C07D471/04 , C07D471/14 , C07D471/22 , C07D487/04 , C07D487/14 , C07K14/79
CPC classification number: A61K33/24 , A61K9/0009 , A61K38/40 , A61K41/0042 , A61K41/0057 , A61K49/0021 , A61N5/062 , A61N2005/0659 , A61K2300/00
Abstract: Compositions of the invention include glycoproteins, such as transferrin, and metal-based coordination complexes, which are preferably chemotherapeutic compounds and more preferably tunable photodynamic compounds. The compositions are useful as in vivo diagnostic agents, and as therapeutic agents for treating or preventing diseases including those that involve hyperproliferating cells in their etiology, such as cancer. Compositions of the invention are further capable of destroying microbial cells, such as bacteria, fungi, and protozoa, and destroying viruses.
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公开(公告)号：EP3137165A4
公开(公告)日：2018-02-14
申请号：EP15786751
申请日：2015-04-29
Applicant: THERALASE TECH INC
Inventor： LILGE LOTHAR , MANDEL ARKADY , DUMOULIN-WHITE ROGER , EMBREE WAYNE
CPC classification number: A61N5/062 , A61B2018/2035 , A61B2018/2065 , A61K41/0057 , A61N5/0616 , A61N2005/0626 , A61N2005/0651 , A61N2005/0652 , A61N2005/0659 , A61N2005/0662 , A61N2005/067
Abstract: A method for treating a condition in a tissue, includes the steps: (1) providing a PS within the tissue; (2) irradiating the tissue containing the PS with a first light of a first wavelength; and (3) irradiating the tissue containing the PS with a second light of a second wavelength so as to treat the condition in the tissue, wherein: (a) the PS absorbs light at the first wavelength and the second wavelength; and (b) the second light is more strongly absorbed by the tissue than the first light or vice versa, so as to achieve a predetermined absorbed photon density gradient. An apparatus for conducting the method includes first and second light sources, a power supply, a focusing device, and a controller which adjusts light emission such that I(d)=I(λ1 at d=0)×exp (μeff (λ1)×d)+I(λ2 at d=0)×exp (μeff(λ2)χd).
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公开(公告)号：CA2947392A1
公开(公告)日：2015-11-05
申请号：CA2947392
申请日：2015-04-29
Applicant: THERALASE TECH INC
Inventor： DUMOULIN-WHITE ROGER , EMBREE WAYNE , MANDEL ARKADY
Abstract: A method for treating a condition in a tissue, includes the steps: (1 ) providing a PS within the tissue; (2) irradiating the tissue containing the PS with a first light of a first wavelength; and (3) irradiating the tissue containing the PS with a second light of a second wavelength so as to treat the condition in the tissue, wherein: (a) the PS absorbs light at the first wavelength and the second wavelength; and (b) the second light is more strongly absorbed by the tissue than the first light or vice versa, so as to achieve a predetermined absorbed photon density gradient. An apparatus for conducting the method includes first and second light sources, a power supply, a focusing device, and a controller which adjusts light emission such that 1(d) = ?(?1 at d=0) x exp (µeff (?1) x d) + ?(?2 at d=0) x exp (µeff(?2) ? d).
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公开(公告)号：CA2947392C
公开(公告)日：2022-11-01
申请号：CA2947392
申请日：2015-04-29
Applicant: THERALASE TECH INC
Inventor： DUMOULIN-WHITE ROGER , EMBREE WAYNE , MANDEL ARKADY
Abstract: A method for treating a condition in a tissue, includes the steps: (1 ) providing a PS within the tissue; (2) irradiating the tissue containing the PS with a first light of a first wavelength; and (3) irradiating the tissue containing the PS with a second light of a second wavelength so as to treat the condition in the tissue, wherein: (a) the PS absorbs light at the first wavelength and the second wavelength; and (b) the second light is more strongly absorbed by the tissue than the first light or vice versa, so as to achieve a predetermined absorbed photon density gradient. An apparatus for conducting the method includes first and second light sources, a power supply, a focusing device, and a controller which adjusts light emission such that 1(d) = ?(?1 at d=0) x exp (µeff (?1) x d) + ?(?2 at d=0) x exp (µeff(?2) ? d).
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Patent Agency Ranking
公开(公告)号：CA2974329A1
公开(公告)日：2016-07-28
申请号：CA2974329
申请日：2016-01-19
Applicant: THERALASE TECH INC
Inventor： MANDEL ARKADY
IPC: A61K41/00 , A61K31/498 , A61K33/24 , A61K38/40 , A61P31/00 , A61P35/00 , C07D213/04 , C07D215/02 , C07D239/24 , C07D401/14 , C07D471/04 , C07D471/14 , C07D471/22 , C07D487/04 , C07D487/14 , C07K14/79
Abstract: Compositions of the invention include glycoproteins, such as transferrin, and metal-based coordination complexes, which are preferably chemotherapeutic compounds and more preferably tunable photodynamic compounds. The compositions are useful as in vivo diagnostic agents, and as therapeutic agents for treating or preventing diseases including those that involve hyperproliferating cells in their etiology, such as cancer. Compositions of the invention are further capable of destroying microbial cells, such as bacteria, fungi, and protozoa, and destroying viruses.
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公开(公告)号：CA3001273A1
公开(公告)日：2017-04-13
申请号：CA3001273
申请日：2016-10-10
Applicant: THERALASE TECH INC , UNIV HEALTH NETWORK , UNIV HEALTH NETWORK
Inventor： LIGLE LOTHAR , DUMOULIN-WHITE ROGER , EMBREE WAYNE , LEM DON , MANDEL ARKADY , WU JENNY
Abstract: Apparatus for illuminating comprises one or more fibers, the one or more fibers including fiber portions meeting at an apex and a bottom location to form a three dimensional cage; a detector attached to each of the fiber portions for receiving light and transmitting light along each of the fiber portions, respectively; and an illumination member situated within the cage. A method for illuminating a hollow member includes the steps of inserting one or more fibers into the hollow member, wherein one or more fibers include fiber portions that meet at a location to form a three-dimensional cage; permitting light to emit from within the three-dimensional cage and towards the fiber portions; receiving light at distinct locations on each of said fibers; and allowing each of the fibers to transmit the light received on each of the fiber portions out of the hollow member.
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公开(公告)号：CA3151035A1
公开(公告)日：2022-09-04
申请号：CA3151035
申请日：2022-03-04
Applicant: THERALASE TECH INC
Inventor： DUMOULIN-WHITE ROGER , MANDEL ARKADY
Abstract: A method for eliciting an immune response in a patient includes the sequential steps of: providing an immunogenic composition including an immunogen; adding a metal-based coordination complex to the immunogenic composition to inactivate or attenuate the immunogen; and administering the immunogenic composition to the patient so as to elicit the immune response against the immunogen. A method for preparing an attenuated immunogenic composition includes the steps of: providing an immunogenic composition including an immunogen; and adding a metal-based coordination complex to the immunogenic composition to inactivate or attenuate the immunogen in the immunogenic composition to provide the attenuated immunogenic composition.
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公开(公告)号：CA3038108A1
公开(公告)日：2019-09-26
申请号：CA3038108
申请日：2019-03-26
Applicant: THERALASE TECH INC
Inventor： DUMOULIN-WHITE ROGER , MANDEL ARKADY
IPC: A61K41/00 , A61K31/05 , A61K31/352 , A61P35/00
Abstract: Disclosed is a method for treating a condition associated with hyperproliferating cells, the method including the steps of administering to a subject having the condition a composition including at least one cannabinoid receptor agonist, optionally administering to the subject a photodynamic compound, and administering radiation to the subject in whom the at least one cannabinoid receptor agonist is present so as to treat the condition.
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公开(公告)号：CA2974329C
公开(公告)日：2018-10-02
申请号：CA2974329
申请日：2016-01-19
Applicant: THERALASE TECH INC
Inventor： MANDEL ARKADY
IPC: A61K41/00 , A61K31/498 , A61K33/24 , A61K38/40 , A61P31/00 , A61P35/00 , C07D213/04 , C07D215/02 , C07D239/24 , C07D401/14 , C07D471/04 , C07D471/14 , C07D471/22 , C07D487/04 , C07D487/14 , C07K14/79
Abstract: Compositions of the invention include glycoproteins, such as transferrin, and metal-based coordination complexes, which are preferably chemotherapeutic compounds and more preferably tunable photodynamic compounds. The compositions are useful as in vivo diagnostic agents, and as therapeutic agents for treating or preventing diseases including those that involve hyperproliferating cells in their etiology, such as cancer. Compositions of the invention are further capable of destroying microbial cells, such as bacteria, fungi, and protozoa, and destroying viruses.
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