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公开(公告)号：ES2387586T3
公开(公告)日：2012-09-26
申请号：ES08704230
申请日：2008-01-31
Applicant: TORAY INDUSTRIES
Inventor： HAYASHI RYOJI , KIKUCHI TSUKASA , ARAI MASAKI , KUROSAWA SATOSHI , HASEBE KO , KANIE SAYOKO , OZONO SEIICHIRO , OTSUKA ATSUSHI
IPC: C07C311/08 , A61K31/18 , A61P13/02
Abstract: Derivado de bencilamina representado por la fórmula general (I)(en el que R1 es alquilo C1-C6, R2 es alquilo C1-C6, R3 y R5 son cada uno, independientemente, alquilo C1-C6,haloalquilo C1-C6, alcoxi C1-C6 o halógeno, y R4 es hidrógeno o alcoxi C1-C6)o una sal de adición de ácido del mismo farmacéuticamente aceptable.
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公开(公告)号：DK2119700T3
公开(公告)日：2012-10-22
申请号：DK08704230
申请日：2008-01-31
Applicant: TORAY INDUSTRIES
Inventor： HAYASHI RYOJI , KIKUCHI TSUKASA , ARAI MASAKI , KUROSAWA SATOSHI , HASEBE KO , KANIE SAYOKO , OZONO SEIICHIRO , OTSUKA ATSUSHI
IPC: C07C311/08 , A61K31/18 , A61P13/02
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公开(公告)号：CA2677061A1
公开(公告)日：2008-08-07
申请号：CA2677061
申请日：2008-01-31
Applicant: TORAY INDUSTRIES
Inventor： KIKUCHI TSUKASA , HAYASHI RYOJI , ARAI MASAKI , KANIE SAYOKO , OTSUKA ATSUSHI , OZONO SEIICHIRO , KUROSAWA SATOSHI , HASEBE KO
IPC: C07C311/08 , A61K31/18 , A61P13/02
Abstract: Disclosed are: a benzylamine derivative typified by the formula below and a pharmaceutically acceptable acid addition salt thereof; a pharmaceutical agent comprising the derivative or the pharmaceutically acceptable acid addi tion salt thereof; and a therapeutic or prophylactic agent for frequent urin ation or urinary incontinence, which comprises the derivative or the pharmac eutically acceptable acid addition salt thereof. The benzylamine derivative and the pharmaceutically acceptable acid addition salt thereof have reduced adverse side effects compared to conventional compounds and high therapeutic effect on frequent urination or urinary incontinence. Therefore, the benzyl amine derivative and the pharmaceutically acceptable acid addition salt ther eof can be used as an excellent therapeutic or prophylactic agent for freque nt urination or urinary incontinence.
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公开(公告)号：AU2008210637A1
公开(公告)日：2008-08-07
申请号：AU2008210637
申请日：2008-01-31
Applicant: TORAY INDUSTRIES
Inventor： KIKUCHI TSUKASA , KUROSAWA SATOSHI , ARAI MASAKI , HASEBE KO , HAYASHI RYOJI , OZONO SEIICHIRO , KANIE SAYOKO , OTSUKA ATSUSHI
IPC: C07C311/08 , A61K31/18 , A61P13/02
Abstract: The benzylamine derivative represented by the formula below and a pharmaceutically acceptable acid addition salt thereof, and a pharmaceutical containing the derivative or the pharmaceutically acceptable acid addition salt thereof, and a therapeutic or prophylactic agent for pollakiuria or urinary incontinence containing the derivative or the pharmaceutically acceptable acid addition salt thereof are provided. The benzylamine derivative of the present invention and the pharmaceutically acceptable acid addition salt thereof have less possibility of occurrence of side effects than known compounds, and show a better therapeutic effect against pollakiuria or urinary incontinence, so that they can be used as excellent therapeutic or prophylactic agents for pollakiuria or urinary incontinence.
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公开(公告)号：CA2508623A1
公开(公告)日：2004-06-24
申请号：CA2508623
申请日：2003-12-05
Applicant: TORAY INDUSTRIES
Inventor： OHNO MICHIHIRO , UEDA HIROSHI , ISOGAYA MASAFUMI , HAYASHI RYOJI
IPC: A61K31/538 , A61P7/02 , A61P9/00 , A61P9/10 , C07D265/36 , C07D413/12
Abstract: Benzomorpholine derivatives typified by compounds represented by the followi ng general formula (VIII), pharmaceutically acceptable salts thereof and platel et aggregation inhibitors comprising the same. Because of having a potent effec t of inhibiting platelet aggregation, these compounds are efficacious in treating and preventing diseases to which thrombi relate. (VIII)
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Patent Agency Ranking
公开(公告)号：CA2374731A1
公开(公告)日：2001-10-04
申请号：CA2374731
申请日：2001-03-30
Applicant: TORAY INDUSTRIES
Inventor： YAMADA NAOHIRO , HAYASHI RYOJI , MORI TAKESHI , ISOGAYA MASAFUMI , KUMAGAI HIROKI
Abstract: Agents controlling hair growth or hair formation which have an excellent effect of controlling hair growth or hair formation while showing little sid e effect. These agents contain as the active ingredient a prostaglandin EP4 receptor agonist.
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公开(公告)号：CA2341542A1
公开(公告)日：2000-12-28
申请号：CA2341542
申请日：2000-06-22
Applicant: TORAY INDUSTRIES
Inventor： OHMORI EIJI , ISOGAYA MASAFUMI , HAYASHI RYOJI , MORIWAKI MITSUHIRO , KUMAGAI HIROKI
IPC: A61K31/4545 , A61K31/496 , A61P9/00 , A61P9/12 , A61P43/00 , C07D209/14 , C07D211/14 , C07D401/04 , C07D401/06 , C07D401/14 , C07D405/04 , C07D413/04 , C07D209/16 , C07D401/12 , C07D215/42 , C07D209/44 , A61K31/4525 , A61K31/454 , A61K31/4709 , A61K31/4725
Abstract: Compounds of the general formula (I) or pharmacologically acceptable acid addition salts thereof; and .alpha.1B-adrenergic receptor antagonists comprising the compounds or the salts: [wherein Ar is indole or the like; R1 is hydrogen or the like; B is a bond or B-N-R1 may form a ring structure suc h as piperidine; n is 0, 1 or the like; A is trimethylene, butylene, or the like; and Q is piperidine, isoindoline, or the like]. The compounds and the salts serve as antagonists having a high affinity for .alpha.1B-adrenergic receptor and are useful as drugs to be used in the prevention and/or treatme nt of .alpha.1B-adrenergic receptor-related diseases (such as hypertension) or as pharmacological tools for the elucidation of physiologic actions occurring through .alpha.1B-adrenergic receptor.
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公开(公告)号：CA2332427A1
公开(公告)日：2000-09-21
申请号：CA2332427
申请日：2000-03-15
Applicant: TORAY INDUSTRIES
Inventor： HAYASHI RYOJI , KUMAGAI HIROKI , OCHI YASUO
IPC: A61K31/5585 , A61P13/12 , A61P43/00 , A61K45/00 , A61K31/557
Abstract: A prostaglandin EP4 receptor agonist containing as the active ingredient a prostaglandin I2 derivative. This compound binds strongly to prostaglandin E P4 receptor, which makes it useful as a pharmacological tool for clarifying physiological functions mediated by prostaglandin EP4 receptor or as a drug to be used in preventing/treating diseases in which prostaglandin EP4 receptor participates.
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公开(公告)号：CA2677061C
公开(公告)日：2014-07-29
申请号：CA2677061
申请日：2008-01-31
Applicant: TORAY INDUSTRIES
Inventor： HAYASHI RYOJI , KIKUCHI TSUKASA , ARAI MASAKI , KUROSAWA SATOSHI , HASEBE KO , KANIE SAYOKO , OZONO SEIICHIRO , OTSUKA ATSUSHI
IPC: C07C311/08 , A61K31/18 , A61P13/02
Abstract: The benzylamine derivative represented by the formula below and a pharmaceutically acceptable acid addition salt thereof, and a pharmaceutical containing the derivative or the pharmaceutically acceptable acid addition salt thereof, and a therapeutic or prophylactic agent for pollakiuria or urinary incontinence containing the derivative or the pharmaceutically acceptable acid addition salt thereof are provided. The benzylamine derivative of the present invention and the pharmaceutically acceptable acid addition salt thereof have less possibility of occurrence of side effects than known compounds, and show a better therapeutic effect against pollakiuria or urinary incontinence, so that they can be used as excellent therapeutic or prophylactic agents for pollakiuria or urinary incontinence. (see above formula)
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公开(公告)号：PL2119700T3
公开(公告)日：2013-01-31
申请号：PL08704230
申请日：2008-01-31
Applicant: TORAY INDUSTRIES
Inventor： HAYASHI RYOJI , KIKUCHI TSUKASA , ARAI MASAKI , KUROSAWA SATOSHI , HASEBE KO , KANIE SAYOKO , OZONO SEIICHIRO , OTSUKA ATSUSHI
IPC: C07C311/08 , A61K31/18 , A61P13/02
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