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公开(公告)号：ES2171742T3
公开(公告)日：2002-09-16
申请号：ES96938475
申请日：1996-11-14
Applicant: TORAY INDUSTRIES
Inventor： KURUMATANI HAJIMU , KAWASHIMA AYAKO , ISOGAYA MASAFUMI , WAKITA HISANORI
IPC: C07D307/93 , A61K31/557
Abstract: This invention relates to an agent for decreasing ocular tension comprising as an effective ingredient a 4,8-inter-m-phenylene PGI2 derivative represented by the formula: or a pharmaceutically acceptable salt thereof. The agent for decreasing ocular tension according to the present invention is useful as a therapeutic agent for treating various high ocular tension states such as glaucoma, ocular hypertension and high ocular tension which occurs after surgery.
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公开(公告)号：DE69305419D1
公开(公告)日：1996-11-21
申请号：DE69305419
申请日：1993-05-27
Applicant: TORAY INDUSTRIES
Inventor： ISOGAYA MASAFUMI , NISHIO SHINTARO
IPC: A61K8/00 , A61K8/49 , A61K31/34 , A61K31/343 , A61K31/557 , A61P43/00 , A61Q5/00 , A61Q7/00 , C07D307/93 , A61K7/06
Abstract: A composition for stimulating hair growth is described. The composition comprises as an effective ingredient a 5,6,7-trinor-4 ,8-inter-m-phenylene prostaglandin I2 derivative of the formula (I) below or a pharmaceutically acceptable salt thereof: (wherein R represents hydrogen, carboxylic group or a functional derivative thereof, -CH2OH or a pharmaceutically acceptable cation; A represents (i) -(CH2)n-, (ii) -(CH2)m-CH=CH-(CH2)p-, (iii) -(CH2)m-C IDENTICAL C-(CH2)p- or (iv) -CH2-O-CH2- (wherein n represents an integer of 0 - 3, m and p, the same or different, represent 0 or 1); R represents (i) C5 - C10 straight or branched alkyl group, (ii) -CtH2t-OR (wherein t represents an integer of 1 - 5, R represents C1 - C5 straight or branched alkyl group or phenyl group), (iii) -CtH2t-CH=C(R )(R > (wherein t represents the same meaning as mentioned above, R and R , the same or different, represent hydrogen, methyl, ethyl, propyl or butyl group), or (iv) -CtH2t-C IDENTICAL C-R (wherein t represents the same meaning as mentioned above, R represents hydrogen, methyl or ethyl group, and -CtH2t in (ii), (iii) and (iv) represent straight or branched alkylene group); wherein said compound of the formula (I) may be d-, l- or dl-form.
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公开(公告)号：CA2097278A1
公开(公告)日：1993-11-30
申请号：CA2097278
申请日：1993-05-28
Applicant: TORAY INDUSTRIES
Inventor： ISOGAYA MASAFUMI , NISHIO SHINTARO
IPC: A61K8/00 , A61K8/49 , A61K31/34 , A61K31/343 , A61K31/557 , A61P43/00 , A61Q5/00 , A61Q7/00 , C07D307/93 , A61K7/06
Abstract: A composition for stimulating hair growth is described. The composition comprises as an effective ingredient a 5,6,7-trinor-4,8-inter-m-phenylene prostaglandin I2 derivative of the formula (I) below or a pharmaceutically acceptable salt thereof: (I) (wherein R1 represents hydrogen, carboxylic group or a functional derivative thereof, -CH2OH or a pharmaceutically acceptable cation; A represents (i) -(CH2)n-, (ii) -(CH2)m-CH=CH-(CH2)p-, (iii) -(CH2)m-C?C-(CH2)p- or (iv) -CH2-O-CH2- (wherein n represents an integer of 0 - 3, m and p, the same or different, represent 0 or 1); R2 represents (i) C5 - C10 straight or branched alkyl group, (ii) -CtH2t-OR3 (wherein t represents an integer of 1 5, R3 represents C1 - C5 straight or branched alkyl group or phenyl group), (iii) -CtH2t-CH=C(R4)(R5) (wherein t represents the same meaning as mentioned above, R4 and R5, the same or different, represent hydrogen, methyl, ethyl, propyl or butyl group), or (iv) -CtH2t-C?C-R6 (wherein t represents the same meaning as mentioned above, R6 represents hydrogen, methyl or ethyl group, and -CtH2t in (ii), (iii) and (iv) represent straight or branched alkylene group); wherein said compound of the formula (I) may be d-, l- or dl-form.
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公开(公告)号：CA2508623A1
公开(公告)日：2004-06-24
申请号：CA2508623
申请日：2003-12-05
Applicant: TORAY INDUSTRIES
Inventor： OHNO MICHIHIRO , UEDA HIROSHI , ISOGAYA MASAFUMI , HAYASHI RYOJI
IPC: A61K31/538 , A61P7/02 , A61P9/00 , A61P9/10 , C07D265/36 , C07D413/12
Abstract: Benzomorpholine derivatives typified by compounds represented by the followi ng general formula (VIII), pharmaceutically acceptable salts thereof and platel et aggregation inhibitors comprising the same. Because of having a potent effec t of inhibiting platelet aggregation, these compounds are efficacious in treating and preventing diseases to which thrombi relate. (VIII)
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公开(公告)号：AT215824T
公开(公告)日：2002-04-15
申请号：AT96938475
申请日：1996-11-14
Applicant: TORAY INDUSTRIES
Inventor： KURUMATANI HAJIMU , KAWASHIMA AYAKO , ISOGAYA MASAFUMI , WAKITA HISANORI
IPC: C07D307/93 , A61K31/557
Abstract: This invention relates to an agent for decreasing ocular tension comprising as an effective ingredient a 4,8-inter-m-phenylene PGI2 derivative represented by the formula: or a pharmaceutically acceptable salt thereof. The agent for decreasing ocular tension according to the present invention is useful as a therapeutic agent for treating various high ocular tension states such as glaucoma, ocular hypertension and high ocular tension which occurs after surgery.
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Patent Agency Ranking
公开(公告)号：CA2374731A1
公开(公告)日：2001-10-04
申请号：CA2374731
申请日：2001-03-30
Applicant: TORAY INDUSTRIES
Inventor： YAMADA NAOHIRO , HAYASHI RYOJI , MORI TAKESHI , ISOGAYA MASAFUMI , KUMAGAI HIROKI
Abstract: Agents controlling hair growth or hair formation which have an excellent effect of controlling hair growth or hair formation while showing little sid e effect. These agents contain as the active ingredient a prostaglandin EP4 receptor agonist.
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公开(公告)号：CA2341542A1
公开(公告)日：2000-12-28
申请号：CA2341542
申请日：2000-06-22
Applicant: TORAY INDUSTRIES
Inventor： OHMORI EIJI , ISOGAYA MASAFUMI , HAYASHI RYOJI , MORIWAKI MITSUHIRO , KUMAGAI HIROKI
IPC: A61K31/4545 , A61K31/496 , A61P9/00 , A61P9/12 , A61P43/00 , C07D209/14 , C07D211/14 , C07D401/04 , C07D401/06 , C07D401/14 , C07D405/04 , C07D413/04 , C07D209/16 , C07D401/12 , C07D215/42 , C07D209/44 , A61K31/4525 , A61K31/454 , A61K31/4709 , A61K31/4725
Abstract: Compounds of the general formula (I) or pharmacologically acceptable acid addition salts thereof; and .alpha.1B-adrenergic receptor antagonists comprising the compounds or the salts: [wherein Ar is indole or the like; R1 is hydrogen or the like; B is a bond or B-N-R1 may form a ring structure suc h as piperidine; n is 0, 1 or the like; A is trimethylene, butylene, or the like; and Q is piperidine, isoindoline, or the like]. The compounds and the salts serve as antagonists having a high affinity for .alpha.1B-adrenergic receptor and are useful as drugs to be used in the prevention and/or treatme nt of .alpha.1B-adrenergic receptor-related diseases (such as hypertension) or as pharmacological tools for the elucidation of physiologic actions occurring through .alpha.1B-adrenergic receptor.
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公开(公告)号：AU2650697A
公开(公告)日：1997-11-26
申请号：AU2650697
申请日：1997-05-01
Applicant: TORAY INDUSTRIES
Inventor： IKARI TAKASHI , MATSUMURA YUZURU , NAKAMURA TSUTOMU , YAJIMA MOTOYUKI , KURUMATANI HAJIMU , KAWASHIMA AYAKO , ISOGAYA MASAFUMI , WAKITA HISANORI
IPC: A61K31/5585 , C07D307/93 , A61K31/557
Abstract: An ophthalmic preparation which exhibits excellent pharmacological effects for various ophthalmic diseases is disclosed. The ophthalmic preparation according to the present invention contains a 4,8-inter-m-phenylene prostaglandin I2 derivative represented by the formula (I): or a pharmaceutically acceptable salt thereof as an effective ingredient.
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公开(公告)号：CA2097278C
公开(公告)日：2004-03-09
申请号：CA2097278
申请日：1993-05-28
Applicant: TORAY INDUSTRIES
Inventor： ISOGAYA MASAFUMI , NISHIO SHINTARO
IPC: A61K8/00 , A61K8/49 , A61K31/34 , A61K31/343 , A61K31/557 , A61P43/00 , A61Q5/00 , A61Q7/00 , C07D307/93 , A61K7/06
Abstract: A composition for stimulating hair growth is described. The composition comprises as an effective ingredient a 5,6,7-trinor-4,8-inter-m-phenylene prostaglandin I2 derivative of the formula (I) below or a pharmaceutically acceptable salt thereof: (see formula I) (wherein R1 represents hydrogen, carboxylic group or a functional derivative thereof, -CH2OH or a pharmaceutically acceptable cation; A represents (i) -(CH2)n-, (ii) -(CH2)m-CH=CH-(CH2)p-, (iii) -(CH2)m-C.ident.C-(CH2)p- or (iv) -CH2-O-CH2- (wherein n represents an integer of 0 - 3, m and p, the same or different, represent 0 or 1); -17- R2 represents (i) C5 - C10 straight or branched alkyl group, (ii) -C t H2t-OR3 (wherein t represents an integer of 1 - 5, R3 represents C1 - C5 straight or branched alkyl group or phenyl group), (iii) -C t H2t-CH=C(R4)(R5) (wherein t represents the same meaning as mentioned above, R4 and R5, the same or different, represent hydrogen, methyl, ethyl, propyl or butyl group), or (iv) -C t H2t-C.ident.C-R6 (wherein t represents the same meaning as mentioned above, R6 represents hydrogen, methyl or ethyl group, and -C t H2t in (ii), (iii) and (iv) represent straight or branched alkylene group); wherein said compound of the formula (I) may be d-, l- or dl-form.
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公开(公告)号：AU734650B2
公开(公告)日：2001-06-21
申请号：AU2650697
申请日：1997-05-01
Applicant: TORAY INDUSTRIES
Inventor： IKARI TAKASHI , MATSUMURA YUZURU , NAKAMURA TSUTOMU , YAJIMA MOTOYUKI , KURUMATANI HAJIMU , KAWASHIMA AYAKO , ISOGAYA MASAFUMI , WAKITA HISANORI
IPC: A61K31/5585 , C07D307/93 , A61K31/557
Abstract: An ophthalmic preparation which exhibits excellent pharmacological effects for various ophthalmic diseases is disclosed. The ophthalmic preparation according to the present invention contains a 4,8-inter-m-phenylene prostaglandin I2 derivative represented by the formula (I): or a pharmaceutically acceptable salt thereof as an effective ingredient.
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