公开(公告)号：CA2586181C

公开(公告)日：2012-11-27

申请号：CA2586181

申请日：2005-11-04

Applicant: TORAY INDUSTRIES

Inventor： IZUMIMOTO NAOKI ,  KAWAMURA KUNIAKI ,  KOMAGATA TOSHIKAZU ,  HASHIMOTO TADATOSHI ,  NAGABUKURO HIROSHI

IPC: A61K31/485 ,  A61P25/04 ,  C07D489/08

Abstract: An analgesic which may be applied to wide variety of pain from various causes is disclosed. The analgesic comprises as an effective ingredient a specific morphinan derivative having a nitrogen containing heterocyclic group, such as comopound 1: (see compound 1)

公开(公告)号：CA2451133C

公开(公告)日：2012-09-18

申请号：CA2451133

申请日：2002-05-08

Applicant: TORAY INDUSTRIES

Inventor： SUZUKI TOMOHIKO ,  INADA HIDEAKI ,  YOSHIZAWA YOSHITAKA ,  KAWAMURA KUNIAKI ,  TANAKA TOSHIAKI

IPC: A61K38/07 ,  A61K31/40 ,  A61K31/485 ,  A61K38/00 ,  A61P7/08 ,  A61P31/02 ,  A61P31/04 ,  C07D489/08 ,  C07K5/107

Abstract: A therapeutic agent for sepsis and various symptoms accompanying sepsis (such as septic shock, disseminated intravascular coagulation syndrome, adult respiratory distress syndrome and multiple organ dysfunction) is disclosed. The therapeutic agent for sepsis according to the present invention comprises as an effective ingredient an opioid .kappa. receptor agonist compound such as (-)-17-(cyclopropylmethyl)-3,14.beta.-dihydroxy-4,5.alpha.-epoxy-6.beta.[N-methyl-trans-3-(3-furyl)acrylamido] morphinan derivative. The opioid .kappa. receptor agonist compound may be administered as it is or in the form of a pharmaceutical composition prepared by mixing the compound with a known pharmaceutically acceptable acid, carrier or vehicle orally or parenterally.

公开(公告)号：HK1115808A1

公开(公告)日：2008-12-12

申请号：HK08106279

申请日：2008-06-05

Applicant: TORAY INDUSTRIES

Inventor： IZUMIMOTO NAOKI ,  KAWAMURA KUNIAKI ,  KOMAGATA TOSHIKAZU ,  HASHIMOTO TADATOSHI ,  NAGABUKURO HIROSHI

IPC: A61K20060101 ,  A61P20060101 ,  C07D20060101

Abstract: An analgesic which may be applied to wide variety of pain from various causes is disclosed. The analgesic comprises as an effective ingredient a specific morphinan derivative having a nitrogen containing heterocyclic group, such as comopound 1 :

公开(公告)号：DE60039444D1

公开(公告)日：2008-08-21

申请号：DE60039444

申请日：2000-08-24

Applicant: TORAY INDUSTRIES

Inventor： NAGASE HIROSHI ,  ENDO TAKASHI ,  KAWAMURA KUNIAKI ,  TANAKA TOSHIAKI ,  SUZUKI TOMOHIKO ,  SUZUKI TSUTOMU ,  KURAISHI YASUSHI ,  SHIRAKI KIMIYASU

IPC: C07D489/06 ,  A61K31/4738 ,  A61K31/4745 ,  A61K31/485 ,  A61K45/00 ,  A61P25/04 ,  C07D471/04 ,  C07D489/08

Abstract: The present invention relates to a therapeutic agent for neuropathic pain containing, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof: (wherein R , R , R , R , R , R , R , R , A, and B have the same definitions as those described in the specification), and an animal model produced by administering (+)-4a-(3-hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octohydro-trans- quinolinoÄ2,3-gÜisoquinoline. The present invention makes it possible to perform drug treatment for neuropathic pain. The therapeutic effect of a compound against neuropathic pain can also be evaluated.

公开(公告)号：MX2007005336A

公开(公告)日：2007-06-25

申请号：MX2007005336

申请日：2005-11-04

Applicant: TORAY INDUSTRIES

Inventor： NAGABUKURO HIROSHI ,  HASHIMOTO TADATOSHI ,  IZUMIMOTO NAOKI ,  KAWAMURA KUNIAKI ,  KOMAGATA TOSHIKAZU

IPC: C07D489/08 ,  A61K31/00 ,  A61P25/04

Abstract: Es descrito un analgesico el cual puede ser aplicado a una amplia variedad de dolor a partir de varias causas. El analgesico comprende como un ingrediente efectivo un derivado de morfinan especifico el cual tiene un grupo heterociclico el cual contiene nitrogeno, tal como el compuesto 1: (ver formula 1).

公开(公告)号：DE69728585T2

公开(公告)日：2004-08-05

申请号：DE69728585

申请日：1997-11-21

Applicant: TORAY INDUSTRIES

Inventor： NAGASE HIROSHI ,  UTSUMI JUN ,  ENDOH TAKASHI ,  TANAKA TOSHIAKI ,  KAWAMURA KUNIAKI ,  KAMEI JUNZO

IPC: A61K31/40 ,  A61K31/4025 ,  A61K31/435 ,  A61K31/485 ,  A61K31/5377 ,  A61K31/541 ,  A61P17/04 ,  C07D489/00 ,  C07D489/08 ,  C07D221/28

Abstract: This invention provides an antipruritic comprising an opiate K receptor agonist as an effective component, and morphinian derivatives which are useful for the treatment of pruritus caused by various diseases.

公开(公告)号：DE69728585D1

公开(公告)日：2004-05-13

申请号：DE69728585

申请日：1997-11-21

Applicant: TORAY INDUSTRIES

Inventor： NAGASE HIROSHI ,  UTSUMI JUN ,  ENDOH TAKASHI ,  TANAKA TOSHIAKI ,  KAWAMURA KUNIAKI ,  KAMEI JUNZO

IPC: A61K31/40 ,  A61K31/4025 ,  A61K31/435 ,  A61K31/485 ,  A61K31/5377 ,  A61K31/541 ,  A61P17/04 ,  C07D489/00 ,  C07D489/08 ,  C07D221/28

Abstract: This invention provides an antipruritic comprising an opiate K receptor agonist as an effective component, and morphinian derivatives which are useful for the treatment of pruritus caused by various diseases.

公开(公告)号：AT263563T

公开(公告)日：2004-04-15

申请号：AT03001740

申请日：1997-11-21

Applicant: TORAY INDUSTRIES

Inventor： NAGASE HIROSHI ,  UTSUMI JUN ,  ENDOH TAKASHI ,  TANAKA TOSHIAKI ,  KAWAMURA KUNIAKI ,  KAMEI JUNZO

IPC: A61K31/40 ,  A61K31/4025 ,  A61K31/435 ,  A61K31/485 ,  A61K31/5377 ,  A61K31/541 ,  A61P17/04 ,  C07D489/00 ,  C07D489/08 ,  C07D221/28

Abstract: This invention provides an antipruritic comprising an opiate K receptor agonist as an effective component, and morphinian derivatives which are useful for the treatment of pruritus caused by various diseases.

公开(公告)号：CA2392993A1

公开(公告)日：2001-06-07

申请号：CA2392993

申请日：2000-11-30

Applicant: TORAY INDUSTRIES

Inventor： KAMEI JUNZO ,  HIRANO NORIYUKI ,  NAGASE HIROSHI ,  KAWAMURA KUNIAKI

IPC: A61K31/4738 ,  A61K31/4745 ,  A61K31/498 ,  A61P25/28 ,  C07D471/04

Abstract: Agents for improving learning or memory which are useful in treating dementi a in association with dysmnesia caused by cerebrovascular disorder, nerve degeneration diseases such as Alzheimer's disease, endocrine diseases, nutritional/metabolic errors, tumor, infectious diseases, drug poisoning, et c. These agents contain as the active ingredient isoquinoline derivatives havin g a specific structure (for example, (4aR,12aR)-2-methyl-4a-(3-hydroxyphenyl)- 1,2,3,4,4a,5,12,12a-octahydro-quinoline[2,3-g]isoquinoline) or pharmacologically acceptable salts thereof.

公开(公告)号：AU6020300A

公开(公告)日：2001-02-05

申请号：AU6020300

申请日：2000-07-19

Applicant: TORAY INDUSTRIES

Inventor： TANAKA TOSHIAKI ,  NAGASE HIROSHI ,  ENDOH TAKASHI ,  KAWAMURA KUNIAKI ,  FUJIMURA MORIHIRO ,  KOMAGATA TOSHIKAZU

IPC: A61K31/485 ,  A61P13/02 ,  C07D489/09 ,  C07D491/20

Abstract: A therapeutic or prophylatic agent for frequent urination or urinary incontinence comprising as an effective ingredient a quinolinomorphinane derivative, for example, of the formula: or a pharmaceutically acceptable acid addition salt thereof.n