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公开(公告)号：CA1204667A
公开(公告)日：1986-05-20
申请号：CA438186
申请日：1983-10-03
Applicant: TORAY INDUSTRIES
Inventor： KODAMA MASASHI , KATAYAMA YUTAKA , TANI TORU , TERAMOTO KAZUO , MURAKAMI MUTSUO
IPC: A61K31/715 , A61K35/74 , A61K31/735
Abstract: BLOOD TREATING AGENT The present invention provides (1) a blood-treating material containing a lipopolysaccharide derived from cell walls of Gram-negative bacteria and immobilized by an insoluble carrier containing an amino group and/or a carboxyl group, and (2) a process for producing the blood-treating material in which a condensing agent is reacted with a mixture of the lipopolysaccharide and the insoluble carrier. Lipopolysaccharides have been known to exhibit antitumor effects against malignant tumors. However, they have not been used safely, since their fatal doses are very close to the minimum effective doses in the treatment of such tumors. The present invention makes it possible to reduce the lethal toxicity of the abovementioned lipopolysaccharides and provide a therapy for cancer, because the unique bloodtreating material disclosed herein not only has antitumor effects similar to those of the lipopolysaccharides derived from the cell walls of Gram-negative bacteria but no fatal effects are observed at antitumor effective dosage levels.
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公开(公告)号：AT25337T
公开(公告)日：1987-02-15
申请号：AT83109905
申请日：1983-10-04
Applicant: TORAY INDUSTRIES
Inventor： KODAMA MASASHI , KATAYAMA YUTAKA , TANI TORU , TERAMOTO KAZUO , MURAKAMI MATSUO
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公开(公告)号：DE3481280D1
公开(公告)日：1990-03-15
申请号：DE3481280
申请日：1984-06-14
Applicant: TORAY INDUSTRIES
Inventor： KODAMA MASASHI , TANI TORU , HANAZAWA KAZUYOSHI , OKA TOTARO , TERAMOTO KAZUO , NISHIUMI SHIRO
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公开(公告)号：DE3369646D1
公开(公告)日：1987-03-12
申请号：DE3369646
申请日：1983-10-04
Applicant: TORAY INDUSTRIES
Inventor： KODAMA MASASHI , KATAYAMA YUTAKA , TANI TORU , TERAMOTO KAZUO , MURAKAMI MATSUO
IPC: A61K31/715 , A61K35/74 , A61K47/00 , A61K37/20 , A61M1/36
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