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公开(公告)号：DK1886704T3
公开(公告)日：2017-01-16
申请号：DK06730892
申请日：2006-03-31
Applicant: TORAY INDUSTRIES
Inventor： SHIMAGAKI MASAAKI , YAMAMURA YASUFUMI , SATO KATSUHISA , TERAMOTO KAZUO , OOZEKI TAKESHIGE , WADA SHIGEHISA
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公开(公告)号：DE3271819D1
公开(公告)日：1986-07-31
申请号：DE3271819
申请日：1982-03-16
Applicant: TORAY INDUSTRIES
Inventor： YOSHIOKA TOSHIO , TERAMOTO KAZUO , SHIMAMURA MASAHARU
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公开(公告)号：CA1204667A
公开(公告)日：1986-05-20
申请号：CA438186
申请日：1983-10-03
Applicant: TORAY INDUSTRIES
Inventor： KODAMA MASASHI , KATAYAMA YUTAKA , TANI TORU , TERAMOTO KAZUO , MURAKAMI MUTSUO
IPC: A61K31/715 , A61K35/74 , A61K31/735
Abstract: BLOOD TREATING AGENT The present invention provides (1) a blood-treating material containing a lipopolysaccharide derived from cell walls of Gram-negative bacteria and immobilized by an insoluble carrier containing an amino group and/or a carboxyl group, and (2) a process for producing the blood-treating material in which a condensing agent is reacted with a mixture of the lipopolysaccharide and the insoluble carrier. Lipopolysaccharides have been known to exhibit antitumor effects against malignant tumors. However, they have not been used safely, since their fatal doses are very close to the minimum effective doses in the treatment of such tumors. The present invention makes it possible to reduce the lethal toxicity of the abovementioned lipopolysaccharides and provide a therapy for cancer, because the unique bloodtreating material disclosed herein not only has antitumor effects similar to those of the lipopolysaccharides derived from the cell walls of Gram-negative bacteria but no fatal effects are observed at antitumor effective dosage levels.
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公开(公告)号：CA3073500A1
公开(公告)日：2019-03-14
申请号：CA3073500
申请日：2018-09-07
Inventor： KASUYA JUNICHI , MATSUNAGA RYO , UENO YOSHIYUKI , UEDA YUJI , TERAMOTO KAZUO , OGASAWARA KAZUMASA
Abstract: The purpose of the present disclosure is to provide an adsorbing material in which the physical strength of a carrier material is maintained and immunosuppressive proteins are efficiently adsorbed. The present disclosure provides an immunosuppressive-protein-adsorbing material that includes a water-insoluble carrier to which is bonded one or more nitrogen-containing compounds selected from polyamines represented by a prescribed formula and aliphatic amines represented by a prescribed formula, the total amount of amino groups on the water-insoluble carrier being greater than 0 µmol and no greater than 2500 µmol per gram, and the amount of primary amino groups on the water-insoluble carrier being no greater than 450 µmol per gram.
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公开(公告)号：CA2603073A1
公开(公告)日：2006-10-12
申请号：CA2603073
申请日：2006-03-31
Applicant: TORAY INDUSTRIES
Inventor： SHIMAGAKI MASAAKI , TERAMOTO KAZUO , YAMAMURA YASUFUMI , OOZEKI TAKESHIGE , WADA SHIGEHISA , SATO KATSUHISA
Abstract: The present invention provides an absorbent which can remove cells present in blood including activated leukocytes such as granulocytes and monocytes, and cancer cells as well as can remove cytokines which facilitate the activation of the remaining cells, and further has no concern for pressure loss and has high configuration stability. That is, the present invention provides an absorbent which absorbs the granulocytes and the monocytes in blood, an absorbent for cancer therapy which absorbs an immunosuppressive protein and an absorbent having a bilayer structure of a net and a nonwoven fabric, having a zeta potential of -20 mV or more, as well as a blood circulation column containing any of the absorbents filled therein.
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Patent Agency Ranking
公开(公告)号：ES2608854T3
公开(公告)日：2017-04-17
申请号：ES06730892
申请日：2006-03-31
Applicant: TORAY INDUSTRIES
Inventor： SHIMAGAKI MASAAKI , YAMAMURA YASUFUMI , SATO KATSUHISA , TERAMOTO KAZUO , OOZEKI TAKESHIGE , WADA SHIGEHISA
Abstract: Un absorbente que tiene la capacidad de absorber granulocitos, monocitos y citocina en sangre, caracterizado por que el absorbente tiene un potencial zeta de -20 mV o mas, el absorbente comprende un portador insoluble en agua que tiene un grupo funcional unido al mismo y el portador insoluble en agua tiene una sal de amonio cuaternario y/o un grupo amino de cadena lineal unidos al mismo.
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公开(公告)号：CA2603073C
公开(公告)日：2012-12-04
申请号：CA2603073
申请日：2006-03-31
Applicant: TORAY INDUSTRIES
Inventor： SHIMAGAKI MASAAKI , YAMAMURA YASUFUMI , SATO KATSUHISA , TERAMOTO KAZUO , OOZEKI TAKESHIGE , WADA SHIGEHISA
Abstract: The present invention provides an absorbent which can remove cells present in blood including activated leukocytes such as granulocytes and monocytes, and cancer cells as well as can remove cytokines which facilitate the activation of the remaining cells, and further has no concern for pressure loss and has high configuration stability. That is, the present invention provides an absorbent which absorbs the granulocytes and the monocytes in blood, an absorbent for cancer therapy which absorbs an immunosuppressive protein and an absorbent having a bilayer structure of a net and a nonwoven fabric, having a zeta potential of -20 mV or more, as well as a blood circulation column containing any of the absorbents filled therein.
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公开(公告)号：AT25337T
公开(公告)日：1987-02-15
申请号：AT83109905
申请日：1983-10-04
Applicant: TORAY INDUSTRIES
Inventor： KODAMA MASASHI , KATAYAMA YUTAKA , TANI TORU , TERAMOTO KAZUO , MURAKAMI MATSUO
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公开(公告)号：AU2018329887A1
公开(公告)日：2020-02-20
申请号：AU2018329887
申请日：2018-09-07
Inventor： UENO YOSHIYUKI , KASUYA JUNICHI , ARAKANE TORU , MATSUNAGA RYO , SEKIYA YUMIKO , UEDA YUJI , TERAMOTO KAZUO , OGASAWARA KAZUMASA
Abstract: An objective of the present disclosure is to provide an adsorption material that can selectively adsorb immunosuppressive leukocyte. The present disclosure provides an adsorption material for immunosuppressive leukocyte. The adsorption material includes a water-insoluble carrier to which at least one nitrogen-containing compound selected from a polyamine represented by a predetermined formula and aliphatic amines represented by predetermined formulae are bound. A form of the water-insoluble carrier is a fiber or a particle, a diameter of the fiber or the particle is 15 to 50 µm, and an arithmetic mean roughness of a surface of the water-insoluble carrier is 0.1 to 3.0 µm.
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公开(公告)号：CA3072044A1
公开(公告)日：2019-03-14
申请号：CA3072044
申请日：2018-09-07
Inventor： UENO YOSHIYUKI , KASUYA JUNICHI , ARAKANE TORU , MATSUNAGA RYO , SEKIYA YUMIKO , UEDA YUJI , TERAMOTO KAZUO , OGASAWARA KAZUMASA
Abstract: The purpose of the present invention is to provide an adsorption material capable of selectively adsorbing immunosuppressive leukocytes. The present disclosure provides an immunosuppressive leukocyte adsorption material containing a water-insoluble carrier to which is bonded one or more nitrogen-containing compounds selected from polyamines represented by a prescribed formula and aliphatic amines represented by a prescribed formula, the water-insoluble carrier having the form of fibers or particles, the diameter of the fibers or the particles being 15-50 µm, and the arithmetic mean roughness of the surface of the water-insoluble carrier being 0.1-3.0 µm.
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