公开(公告)号：JPH01143884A

公开(公告)日：1989-06-06

申请号：JP30519487

申请日：1987-12-01

Applicant: TORAY INDUSTRIES

Inventor： MUTOU MASANORI ,  FUJIKAWA KAZUHIRO ,  IMAMURA SHINZO ,  SUGAWARA YOSHINORI

IPC: A61K31/555 ,  A61K31/28 ,  A61K31/282 ,  A61K33/24 ,  A61P35/00 ,  C07F15/00

Abstract: NEW MATERIAL:A compound expressed by formula I (R represents 2-buryl or 2-tetrahydrofuryl). EXAMPLE:Bis(2-furancarboxylate) (trans-l-diaminocyxlohexane) platinum (II) complex. USE:A remedy for malignant tumor, which is administered at a daily dose of 0.01-50mg/adult body weight. PREPARATION:2-Furancarboxylic acid or 2-tetrahydrofurancarboxylic acid is reacted with dihydroxodiaminocyclohexane platinum (II) expressed by formula II normally at ordinary temperature under ordinary pressure in an aqueous solution.

公开(公告)号：JPH01165594A

公开(公告)日：1989-06-29

申请号：JP32649787

申请日：1987-12-22

Applicant: TORAY INDUSTRIES

Inventor： MUTOU MASANORI ,  FUJIKAWA KAZUHIRO ,  IMAMURA SHINZO ,  SUGAWARA YOSHINORI

IPC: C07D207/452 ,  C07F15/00

Abstract: NEW MATERIAL:A compound expressed by formula I. USE:A remedy for malignant tumor having low toxicity. PREPARATION:N-(4-Carboxylphenyl)maleimide expressed by formula II is reacted with dihydroxodiaminocyclohexane platinum (II) expressed by formula III, normally under ordinary temperature and ordinary pressure in an aqueous solution to provide the compound expressed by formula I. Furthermore, the compound expressed by formula III which is a starting raw material is produced by heating N-(4-carboxyphenyl)maleimide in an acetic anhydride solvent in the presence of sodium acetate. The compound expressed by formula III is produced by reacting a compound expressed by the formula K2PtCl4 with a compound expressed by formula IV, reacting the resultant compound expressed by formula V with AgNO3 and then treating the resultant compound expressed by formula VI with a OH type anion exchange resin.