公开(公告)号：JPH01163191A

公开(公告)日：1989-06-27

申请号：JP32230087

申请日：1987-12-18

Applicant: TORAY INDUSTRIES

Inventor： HASEGAWA SAKIE ,  IMAMURA SHINZO ,  MUTOU MASANORI ,  SAWAHATA TADASHI

IPC: A61K33/24 ,  A61K31/555 ,  A61P35/00 ,  C07F15/00

Abstract: NEW MATERIAL:A compound expressed by formula I (R represents 1-17C alkyl). EXAMPLE:5-Acetyl-2,2-dimethyl-1,3-dioxan-4,6-dione-hydroxo(trans-l-1,2- diaminocyclohexane) platinum(II). USE:A remedy for malignant tumor, which is administrated at 0.01-50mg per day.adult body weight. PREPARATION:Dinitrato(1,2-diaminocyclohexane)platinum(II) expressed by formula II is reacted with a 5-acyl-2,2-dimethyl-1,3-dioxane-4,6-dione expressed by formula III in the presence of an alkali hydroxide normally at ordinary temperature under ordinary pressure.

公开(公告)号：JPS63303988A

公开(公告)日：1988-12-12

申请号：JP13868187

申请日：1987-06-02

Applicant: TORAY INDUSTRIES

Inventor： MATSUNAGA KEIICHI ,  FUJIKAWA KAZUHIRO ,  MUTOU MASANORI

IPC: C07F15/00 ,  A61K31/28 ,  A61K31/282 ,  A61P35/00

Abstract: NEW MATERIAL:A compound expressed by the formula (R represents H, methyl or benzyl). EXAMPLE:cis-Dichloro(L-3-aminoperhydroazepine)platinum (II). USE:A remedy for therioma. PREPARATION:Potassium chloroplatinate (II) is reacted with a 3-aminoperhydroa zepine derivative in an aqueous solution at normal temperature under normal pressure.

公开(公告)号：JPH01143883A

公开(公告)日：1989-06-06

申请号：JP30519387

申请日：1987-12-01

Applicant: TORAY INDUSTRIES

Inventor： MUTOU MASANORI ,  MATSUNAGA KEIICHI ,  IMAMURA SHINZO ,  HANADA SATORU

IPC: A61K31/28 ,  A61K31/282 ,  A61K33/24 ,  A61P35/00 ,  C07F15/00

Abstract: NEW MATERIAL:A compound expressed by formula I. USE:A remedy for malignant tumor, which is administered at a rate of 0.01-50mg/day. adult body weight. PREPARATION:An aqueous solution of dinitrato (1,2-diaminocyclohexane) platinum (II) expressed by formula II is passed through a column packed with an anion-exchange resin to afford dihydroxo (1,2-diaminocyclohexane) platinum (II) expressed by formula III, which is reacted with salicylaldehyde expressed by formula IV normally at ordinary temperature under ordinary pressure in an inert gas atmosphere using water as a solvent.

公开(公告)号：JPS63303987A

公开(公告)日：1988-12-12

申请号：JP13868087

申请日：1987-06-02

Applicant: TORAY INDUSTRIES

Inventor： FUJIKAWA KAZUHIRO ,  IMAMURA SHINZO ,  MUTOU MASANORI ,  HANADA SATORU

IPC: C07F15/00 ,  A61K31/28 ,  A61K31/282 ,  A61P35/00

Abstract: NEW MATERIAL:m-Hydroxybenzonate-hydroxo ( trans-l-diaminocyclohexane ) platinum (II) complex expressed by formula I. USE:A remedy for therioma. PREPARATION:A m-hydroxybenzoic acid expressed by formula II is reacted with an aqueous solution of dihydroxodiaminocyclohexane-platinum (II) expressed by formula III preferably at 50-80 deg.C under normal pressure.

公开(公告)号：JPH01165593A

公开(公告)日：1989-06-29

申请号：JP32499487

申请日：1987-12-21

Applicant: TORAY INDUSTRIES

Inventor： MUTOU MASANORI ,  FUJIKAWA KAZUHIRO ,  IMAMURA SHINZO ,  HASHIMOTO HIDEYUKI

IPC: C07F15/00 ,  A61K31/28 ,  A61K31/282 ,  A61K33/24 ,  A61P35/00

Abstract: NEW MATERIAL:A compound expressed by formula I. USE:A remedy for malignant tumor having low toxicity. PREPARATION:Methoxyethoxymethylcarboxylic acid expressed by formula II is reacted with dihydroxodiaminocyclohexane platinum (II) expressed by formula III, normally under ordinary temperature and ordinary pressure to provide the compound expressed by formula I. Furthermore, the compound expressed by formula III which is a starting raw material can be produced by reacting a compound expressed by the formula K2PtCl4 with a compound expressed by formula IV, reacting the resultant compound expressed by formula V with AgNO3 and treating the resultant compound expressed by formula VI with a OH type anion exchange resin. The compound expressed by formula II can be synthesized from methylcellosolve and monochloroacetic acid using metal sodium.

公开(公告)号：JPH01143884A

公开(公告)日：1989-06-06

申请号：JP30519487

申请日：1987-12-01

Applicant: TORAY INDUSTRIES

Inventor： MUTOU MASANORI ,  FUJIKAWA KAZUHIRO ,  IMAMURA SHINZO ,  SUGAWARA YOSHINORI

IPC: A61K31/555 ,  A61K31/28 ,  A61K31/282 ,  A61K33/24 ,  A61P35/00 ,  C07F15/00

Abstract: NEW MATERIAL:A compound expressed by formula I (R represents 2-buryl or 2-tetrahydrofuryl). EXAMPLE:Bis(2-furancarboxylate) (trans-l-diaminocyxlohexane) platinum (II) complex. USE:A remedy for malignant tumor, which is administered at a daily dose of 0.01-50mg/adult body weight. PREPARATION:2-Furancarboxylic acid or 2-tetrahydrofurancarboxylic acid is reacted with dihydroxodiaminocyclohexane platinum (II) expressed by formula II normally at ordinary temperature under ordinary pressure in an aqueous solution.

公开(公告)号：JPH01165594A

公开(公告)日：1989-06-29

申请号：JP32649787

申请日：1987-12-22

Applicant: TORAY INDUSTRIES

Inventor： MUTOU MASANORI ,  FUJIKAWA KAZUHIRO ,  IMAMURA SHINZO ,  SUGAWARA YOSHINORI

IPC: C07D207/452 ,  C07F15/00

Abstract: NEW MATERIAL:A compound expressed by formula I. USE:A remedy for malignant tumor having low toxicity. PREPARATION:N-(4-Carboxylphenyl)maleimide expressed by formula II is reacted with dihydroxodiaminocyclohexane platinum (II) expressed by formula III, normally under ordinary temperature and ordinary pressure in an aqueous solution to provide the compound expressed by formula I. Furthermore, the compound expressed by formula III which is a starting raw material is produced by heating N-(4-carboxyphenyl)maleimide in an acetic anhydride solvent in the presence of sodium acetate. The compound expressed by formula III is produced by reacting a compound expressed by the formula K2PtCl4 with a compound expressed by formula IV, reacting the resultant compound expressed by formula V with AgNO3 and then treating the resultant compound expressed by formula VI with a OH type anion exchange resin.

公开(公告)号：JPH01163192A

公开(公告)日：1989-06-27

申请号：JP32230187

申请日：1987-12-18

Applicant: TORAY INDUSTRIES

Inventor： HASEGAWA SAKIE ,  IMAMURA SHINZO ,  MUTOU MASANORI ,  OKAMOTO YUTAKA

IPC: A61K33/24 ,  A61K31/555 ,  A61P35/00 ,  C07F15/00

Abstract: NEW MATERIAL:A compound expressed by formula I (R represents 1-17C alkyl). EXAMPLE:5-Acetyl-2,4,6(1H,3H,5H)-pyrimidine-trione-hydroxo(trans-l-1,2- diaminocyclohexane)platinum(II) complex.monohydrate. USE:A remedy for malignant tumor, which is administrated at 0.01-50mg per day.adult body weight. PREPARATION:Dinitrato(1,2-diaminocyclohexane)platinum (II) expressd by formula II is reacted with a 5-acyl-2,4,6(1H,3H,5H)-pyrimidine-trione in the presence of an alkali hydroxide normally at ordinary temperature under ordinary pressure.

公开(公告)号：JPH01163190A

公开(公告)日：1989-06-27

申请号：JP32229987

申请日：1987-12-18

Applicant: TORAY INDUSTRIES

Inventor： MUTOU MASANORI ,  FUJIKAWA KAZUHIRO ,  IMAMURA SHINZO ,  HASHIMOTO HIDEYUKI

IPC: A61K33/24 ,  A61K31/555 ,  A61P35/00 ,  C07F15/00

Abstract: NEW MATERIAL:Bisphthaloylglycylglycinato-(trans->=-diaminocyclohexane) platinum(II) complex expressed by formula I. USE:A remedy for a malignant tumor with low toxicity and hardly any side-effect. PREPARATION:A sodium hydroxide-aqueous solution of sodium phthaloylglycylglycine expressed by formula II is reacted with an aqueous solu tion of dinitrate diaminocyclohexaneplatinum(II) diaquo complex expressed by formula III at normal temperature -100 deg.C under normal pressure.

公开(公告)号：JPH01132595A

公开(公告)日：1989-05-25

申请号：JP29249387

申请日：1987-11-19

Applicant: TORAY INDUSTRIES

Inventor： MUTOU MASANORI ,  MATSUNAGA KEIICHI ,  IMAMURA SHINZO ,  HANADA SATORU

IPC: A61K33/24 ,  A61K31/555 ,  A61P35/00 ,  C07F15/00

Abstract: NEW MATERIAL:A compound of formula I (R is H, acyl; dotted line means single or double bonds). EXAMPLE:Platinum (II) bis(indole-2-carboxylate)(trans-L-1,2-diaminocyclohexane). USE:A remedy for malignant tumor. PREPARATION:The reaction of dinitrato(1,2-diaminocyclohexane)platinum (II) with an indole-carboxylic acid or indoline-carboxylic acid or its acetyl derivative is carried out in the presence of an alkali hydroxide.