公开(公告)号：DE69722178T2

公开(公告)日：2003-11-27

申请号：DE69722178

申请日：1997-11-21

Applicant: TORAY INDUSTRIES

Inventor： UYAMA MASANOBU ,  TAKAHASHI KANJI ,  SONE SABURO ,  KIJIMA ATSUSHI ,  UTSUMI JUN

IPC: A61K38/21 ,  A61P27/02 ,  A61K38/19

Abstract: The remedy comprising interferon as the active principle in accordance with the present invention can be used as a remedy or preventive which is useful for retinal edema, and particularly cystoid macular edema which do not have established therapies and drug therapies.

公开(公告)号：CA2144580A1

公开(公告)日：1996-03-13

申请号：CA2144580

申请日：1995-03-14

Applicant: TORAY INDUSTRIES

Inventor： TOBE TAKAO ,  TAKAHASHI KANJI ,  OHKUMA HIROSHI ,  UYAMA MASANOBU

IPC: A61K38/21 ,  A61P27/02

Abstract: A pharmaceutical composition for use as a retinal pigment epithelial cell growth stimulating agent comprising an interferon and a pharmaceutically acceptable carrier is disclosed. The composition is useful as a therapeutic agent for oculopathies, such as pigmentary retinal degeneration, central chorioretinopathy, and macular dystrophy.

公开(公告)号：CA2243161A1

公开(公告)日：1998-05-28

申请号：CA2243161

申请日：1997-11-21

Applicant: TORAY INDUSTRIES

Inventor： KIJIMA ATSUSHI ,  UYAMA MASANOBU ,  UTSUMI JUN ,  TAKAHASHI KANJI ,  SONE SABURO

IPC: A61K38/21 ,  A61P27/02

Abstract: A therapeutic agent comprising interferon as the active ingredient, which is useful for the treatment and prevention of retinal edema, particularly cystlike macular edema, for which neither therapy nor pharmacotherapy have been satisfactorily established.

公开(公告)号：DE69722178D1

公开(公告)日：2003-06-26

申请号：DE69722178

申请日：1997-11-21

Applicant: TORAY INDUSTRIES

Inventor： UYAMA MASANOBU ,  TAKAHASHI KANJI ,  SONE SABURO ,  KIJIMA ATSUSHI ,  UTSUMI JUN

IPC: A61K38/21 ,  A61P27/02 ,  A61K38/19

Abstract: The remedy comprising interferon as the active principle in accordance with the present invention can be used as a remedy or preventive which is useful for retinal edema, and particularly cystoid macular edema which do not have established therapies and drug therapies.

公开(公告)号：JPH0881389A

公开(公告)日：1996-03-26

申请号：JP21721594

申请日：1994-09-12

Applicant: TORAY INDUSTRIES

Inventor： TOBE TAKAO ,  TAKAHASHI KANJI ,  OKUMA HIROSHI ,  UYAMA MASANOBU

IPC: A61K38/21 ,  A61P27/02

Abstract: PURPOSE: To obtain a new medicinal agent containing an interferon as an active ingredient, exhibiting an action for inhibiting a new blood vessel itself and activating and multiplying the pigment epithelial cells of the retinae, and useful for eye diseases such as central chorioretinitis. CONSTITUTION: The retinal pigment epithelial cell-multiplying agent contains preferably a natural interferon-β as an active ingredient. The natural interferon βis obtained as a human interferon β-containing solution by subjecting an interferon β-producing cell cultured on the surface of glass or plastics, etc., to e.g. an induction treatment using a synthetic double strand chain RNA such as Poly I:C, further subjecting the product to an ultrainduction treatment, and subsequently cultured in a culture medium for 20-48 hrs. The human interferon- containing solution is preferably concentrated and purified with a chromatography using a blue pigment-bound insoluble carrier and a metal chelate-bonded carrier. The agent is administered at a dose of 10000-10000000 units/day, preferably 1000000-6000000.

公开(公告)号：EP0878200A4

公开(公告)日：2000-05-17

申请号：EP97912538

申请日：1997-11-21

Applicant: TORAY INDUSTRIES

Inventor： UYAMA MASANOBU ,  TAKAHASHI KANJI ,  SONE SABURO ,  KIJIMA ATSUSHI ,  UTSUMI JUN

IPC: A61K38/21 ,  A61P27/02 ,  A61K38/19

CPC classification number: A61K38/21

Abstract: The remedy comprising interferon as the active principle in accordance with the present invention can be used as a remedy or preventive which is useful for retinal edema, and particularly cystoid macular edema which do not have established therapies and drug therapies.

Abstract translation: 包含根据本发明的干扰素作为活性成分的治疗方法可用作对视网膜水肿有用的补救措施或预防措施，特别是尚未建立治疗和药物治疗的囊状黄斑水肿。