公开(公告)号：JPH06142181A

公开(公告)日：1994-05-24

申请号：JP29434492

申请日：1992-11-02

Applicant: TORAY INDUSTRIES

Inventor： SHOJI HISANORI ,  YAMAMOTO YASUHIRO ,  KODAMA MASATOMO ,  MITSUNAGA MASAHIRO ,  MURAKAMI MUTSUO ,  SUYAMA TOMOKO ,  NAGAYASU NAOTO

IPC: A61K9/70 ,  A61K38/00 ,  A61L15/44 ,  A61K37/02

Abstract: PURPOSE:To provide the wound coating material which exhibits an antimicrobial property even without releasing drugs and has a detoxication power to a bacterial toxin by immobilizing polypeptide antibiotics by cavalent bonding to the surfaces of fibers constituting cloth. CONSTITUTION:A polypeptide-based antibiotic is immobilized by covalent bonding to the surfaces of the fibers constituting cloth of a wound coating material. The ratio of the extension rate in the biaxial directions orthogonal to each other of the cloth surface is specified to >=50%. The cloth is formed of a knitted fabric cross knitted of blended fiber consisting of plural blank materials, combined filament yarns and/or plural fibers. As a result, the treatment of the wound is possible without allowing the intrusion of antibiotic into the body through the wound part, and therefore, side effects are prevented. Since an infection prevented, the treatment environment of the wound is improved and further the microbial cell toxin is adsorbed, and therefore an inflammation reaction is suppressed and healing is accelerated.