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    4.
    发明专利
    未知

    公开(公告)号：AT470710T

    公开(公告)日：2010-06-15

    申请号：AT02749365

    申请日：2002-07-24

    Applicant: TOSOH CORP

    Inventor： TSUCHIYA SHIGEO ,  MASUDA NORIYOSHI ,  MARUYAMA TAKAHIRO ,  MATSUBA TAKAO ,  ISHIGURO TAKAHIKO

    IPC: C12N15/00 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/566 ,  G01N33/569 ,  G01N33/58

    Abstract: Oligonucleotides comprising not less than 10 consecutive bases in the sequences of (I)-(XX) with 20-23 base pairs for use in cleaving, detecting or amplifying essential pab genes of tubercle bacillus or RNA originated from them and capable of binding specifically with such genes or RNA, or their complementary oligonucleotides, are new. An independent claim is also included for a method for the detection of tubercle bacillus-originated pab genes comprising: (a) using specific sequences of the pab genes or their derived RNA in a sample as template, and a first primer containing sequences analogous to such specific sequences and a second primer containing sequences complementary to these specific sequences (provided that any of the first and second primers has a sequence attached with a promoter sequence of RNA polymerase at its 5'-side), with RNA-dependent DNA polymerase for cDNA synthesis, and producing single-stranded DNA by decomposition of the RNA of an RNA-DNA double strand by ribonuclease H; (b) using the single-stranded DNA as template for DNA-dependent DNA polymerase to form a double-stranded DNA with a promoter sequence for transcription of an RNA from the specific sequences or their complementary sequences and subsequently producing an RNA product in the presence of an RNA polym erase with the double-stranded DNA; (c) RNA amplification with such RNA transcription product as template for cDNA synthesis by the RNA-dependent DNA polymerase, wherein the first and second primers can also be those of not less than 10 bases long derived from sequences (XXVIII)-(XXXIII) all with 51 base pairs and from sequences (XXXIV)-(XLI) with 20-23 base pairs, identical to a part of the RNA sequence originating in the pab genes or their complementary sequences, for amplification.

    Replicator for multi-well plate
    8.
    发明专利
    Replicator for multi-well plate 审中-公开
    多层板替代者

    公开(公告)号：JP2008079517A

    公开(公告)日：2008-04-10

    申请号：JP2006260934

    申请日：2006-09-26

    Applicant: Tosoh Corp ,  東ソー株式会社

    Inventor： MIYAUCHI YUKA ,  MATSUBA TAKAO

    IPC: C12M1/00

    Abstract: PROBLEM TO BE SOLVED: To provide a replicator the pin-like members of which are readily replaceable, at low cost.
    SOLUTION: The replicator 10 is equipped with a first substrate 12 and a second substrate 14 provided with holes 28 for pins corresponding to implanted positions of the pin-like members 16. Furthermore, the pin-like members 16 have a rod-like leg part 20 and a head part 18 overhanging at least a part in the radial direction of the leg part 20, respectively. The leg part 20 is projected from each hole 28 for the pins of the second substrate. The head part 18 is nipped between the first substrate 12 and the second substrate 14 and fixed.
    COPYRIGHT: (C)2008,JPO&INPIT

    Abstract translation: 要解决的问题：为了提供可以以低成本容易地替换的销状构件的复制器。 解决方案：复制器10配备有第一基板12和第二基板14，第二基板14设置有与针状部件16的注入位置对应的销的孔28.另外，销状部件16具有杆状部件16。 并且分别在腿部20的径向方向上悬伸至少一部分的头部18。 腿部20从每个孔28突出，用于第二基底的销。 头部18夹在第一基板12和第二基板14之间并固定。 版权所有（C）2008，JPO＆INPIT

    Antibody, antibody-containing adsorbent and immunoassay reagent
    9.
    发明专利
    Antibody, antibody-containing adsorbent and immunoassay reagent 有权
    抗体，含抗菌药物和免疫测试试剂

    公开(公告)号：JP2006029789A

    公开(公告)日：2006-02-02

    申请号：JP2004204271

    申请日：2004-07-12

    Applicant: Tosoh Corp ,  東ソー株式会社

    Inventor： YAMADA MASASHI ,  MISAWA KOICHI ,  HONMA NOBUYUKI ,  MATSUBA TAKAO

    IPC: G01N33/531 ,  B01J20/281 ,  C07K16/44 ,  G01N30/00 ,  G01N30/88 ,  G01N33/53

    Abstract: PROBLEM TO BE SOLVED: To provide a more excellent method for avoiding an effect of a medicine as a countermeasure against the problem wherein a case showing an abnormal value is confirmed when the specimen of a patient is measured using an immunoassay reagent.
    SOLUTION: A medicine metabolite adsorbent containing an antibody specifically reacting with the metabolite of the medicine is prepared, and this adsorbent is brought into contact with the specimen to adsorb the medicine metabolite in the specimen. The adsorbent is added to the immunoassay reagent and this immunoassay reagent is used to perform immunoassay reduced in fear showing the abnormal value. This method is especially useful when a metabolite of dichlorophenacs coexists in the specimen and the immunoassay of total triiodothyronine and/or free type triiodothyronine is performed.
    COPYRIGHT: (C)2006,JPO&NCIPI

    Abstract translation: 要解决的问题：提供一种更优异的避免药物效果的方法，作为对使用免疫测定试剂测定患者体内的病例的情况下的异常值的判定的对策。 解决方案：制备含有与药物代谢物特异性反应的抗体的药物代谢物吸附剂，使该吸附剂与样品接触以吸附样品中的药物代谢物。 将吸附剂加入到免疫测定试剂中，并使用该免疫测定试剂进行免疫测定，显示异常值的恐惧降低。 当二氯苯甲酸的代谢物共存在样品中并且进行总三碘甲状腺原氨酸和/或游离型三碘甲状腺原氨酸的免疫测定时，该方法特别有用。 版权所有（C）2006，JPO＆NCIPI

    Oligonucleotide for tubercule bacillus detection
    10.
    发明专利
    Oligonucleotide for tubercule bacillus detection 审中-公开
    用于管状杆菌检测的寡核苷酸

    公开(公告)号：JP2003033182A

    公开(公告)日：2003-02-04

    申请号：JP2001224436

    申请日：2001-07-25

    Applicant: Tosoh Corp ,  東ソー株式会社

    Inventor： TSUCHIYA SHIGEO ,  MASUDA NORIYOSHI ,  MARUYAMA TAKAHIRO ,  MATSUBA TAKAO ,  ISHIGURO NORIHIKO

    IPC: C12N15/09 ,  C12Q1/68

    Abstract: PROBLEM TO BE SOLVED: To obtain an oligonucleotide useful for specifically cleaving or amplifying a pab gene encoding antigen protein pab of tubercule bacillus or a RNA derived from the gene and detecting and identifying them in high sensitivity.
    SOLUTION: This oligonucleotide is useful for cleaving, detecting or amplifying a pab gene of tubercule bacillus or a RNA derived from the gene, can specifically be bonded to the pab gene or the RNA derived from the gene and is composed of at least ≥10 continuous bases in a specific sequence or an oligonucleotide complementary to the oligonucleotide.
    COPYRIGHT: (C)2003,JPO

    Abstract translation: 要解决的问题：获得用于特异性切割或扩增编码结核菌杆菌的抗原蛋白质pab的pab基因的寡核苷酸或从该基因衍生的RNA，并以高灵敏度检测和鉴定它们。 解决方案：该寡核苷酸可用于切割，检测或扩增结核杆菌的pab基因或源自该基因的RNA，可以特异性地结合到pab基因或源自该基因的RNA，并且由至少> = 10 与特定序列连续的碱基或寡核苷酸互补的寡核苷酸。

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