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    METHOD FOR CRYSTALLIZING &-L-ASPARTYL-L-PHENYLALANINE METHYL ESTER
    3.
    发明专利
    METHOD FOR CRYSTALLIZING &-L-ASPARTYL-L-PHENYLALANINE METHYL ESTER 未知

    公开(公告)号：CA2017137A1

    公开(公告)日：1990-11-22

    申请号：CA2017137

    申请日：1990-05-18

    Applicant: STAMICARBON ,  TOSOH CORP

    Inventor： IRINO SHIGEAKI ,  WAKAMATSU HIDETOSHI ,  KUNISAWA YUKIO ,  STOELWINDER CHRISTIAAN J C ,  TOUSSAINT ANTOON G T

    IPC: C07K1/14 ,  C07K1/30 ,  C07K5/072 ,  C07K5/075 ,  C07K5/06

    Abstract: - 14 - (14) AE 6335 A method for crystallizing .alpha.-L-aspartyl-L-phenyl-alanine methyl ester, which comprises mixing a hot aqueous solution containing .alpha.-L-aspartyl-L-phenylalanine methyl ester and a cold aqueous solution which may contain .alpha.-L-aspartyl-L-phenylalanine methyl ester, in such proportions that the concentration of .alpha.-L-aspartyl-L-phenylalanine methyl ester after mixing exceeds its solubility in the mixture of the two aqueous solutions at the temperature of the mixture, to precipitate crystals of .alpha.-L-aspartyl-L-phenylalanine methyl ester, and if necessary, cooling the mixture, the total amount of .alpha.-L-aspartyl-L-phenylalanine methyl ester contained in the hot and cold aqueous solutions being such that when the two aqueous solutions are mixed to precipitate crystals of .alpha.-L-aspartyl-L-phenylalanine methyl ester, it exceeds the solubility level of .alpha.-L-aspartyl-L-phenylalanine methyl ester in the mixture of the two aqueous solutions at the temperature of the mixture.

    PREPARATION OF GRANULAR DIPEPTIDE SWEETENER
    5.
    发明专利
    PREPARATION OF GRANULAR DIPEPTIDE SWEETENER 失效

    公开(公告)号：JPH02174650A

    公开(公告)日：1990-07-06

    申请号：JP32620088

    申请日：1988-12-26

    Applicant: TOSOH CORP

    Inventor： SHIOKAWA YUTAKA ,  KUNISAWA YUKIO ,  HARADA TSUNEO

    IPC: A23L27/30 ,  C07K1/00 ,  C07K5/06 ,  C07K5/075

    Abstract: PURPOSE:To prepare a granular dipeptide sweetener having high purity and excellent fluidity and solubility by spray-drying a slurry of a dipeptide sweetener without using a crushing operation, granulating the dried product and, as necessary, further drying the granules. CONSTITUTION:A slurry liquid containing crystals of an alpha-L-aspartyl-L- phenylalanine lower alkyl ester is spray-dried to obtain a dried product having extremely poor fluidity and containing a large amount of fusiform fine powder of

    6.
    发明专利
    失效

    公开(公告)号：JPH05286994A

    公开(公告)日：1993-11-02

    申请号：JP11846492

    申请日：1992-04-13

    Applicant: TOSOH CORP

    Inventor： WAKAMATSU HIDETOSHI ,  HARADA TSUNEO ,  KUNISAWA YUKIO ,  KOYAMA KIYOTAKA

    IPC: A23L27/30 ,  C07K1/14 ,  C07K5/06 ,  C07K5/072 ,  C07K5/075

    Abstract: PURPOSE:To crystallize a crystal of the subject compound having good filtrating property and dehydrating property by continuously feeding a hot water solution containing alpha-L-aspartyl-L-phenylalanine methyl ester to a crystallizing tank cooled to a temperature or below at which the compound is dissolved. CONSTITUTION:Whenalpha-L-aspartyl-L-phenylalanine methyl ester (A2PM) is crystallized from a hot water solution containing alpha-L-aspartyl-L-phenylalanine methyl ester by cooling, the crystallization of A2PM is carried out by continuously feeding a hot water solution in which the content of L-aspartyl-Laspartyl-L- phenylalanine methyl ester (A2PM) is 0.6% smaller than the of alpha-L-spartyl-L- phenylalanine methyl ester to a crystallizing tank cooled to a temperature or below at which alpha-L-aspartyl-L-phenylalanine methyl ester is dissolved and simultaneously continuously drawing out the produced slurry from the crystallizing tank.

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