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公开(公告)号:JPH0372497A
公开(公告)日:1991-03-27
申请号:JP13235090
申请日:1990-05-22
Applicant: TOSOH CORP , STAMICARBON
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公开(公告)号:AT134193T
公开(公告)日:1996-02-15
申请号:AT90201273
申请日:1990-05-19
Applicant: STAMICARBON , TOSOH CORP
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公开(公告)号:CA2017137A1
公开(公告)日:1990-11-22
申请号:CA2017137
申请日:1990-05-18
Applicant: STAMICARBON , TOSOH CORP
Inventor: IRINO SHIGEAKI , WAKAMATSU HIDETOSHI , KUNISAWA YUKIO , STOELWINDER CHRISTIAAN J C , TOUSSAINT ANTOON G T
Abstract: - 14 - (14) AE 6335 A method for crystallizing .alpha.-L-aspartyl-L-phenyl-alanine methyl ester, which comprises mixing a hot aqueous solution containing .alpha.-L-aspartyl-L-phenylalanine methyl ester and a cold aqueous solution which may contain .alpha.-L-aspartyl-L-phenylalanine methyl ester, in such proportions that the concentration of .alpha.-L-aspartyl-L-phenylalanine methyl ester after mixing exceeds its solubility in the mixture of the two aqueous solutions at the temperature of the mixture, to precipitate crystals of .alpha.-L-aspartyl-L-phenylalanine methyl ester, and if necessary, cooling the mixture, the total amount of .alpha.-L-aspartyl-L-phenylalanine methyl ester contained in the hot and cold aqueous solutions being such that when the two aqueous solutions are mixed to precipitate crystals of .alpha.-L-aspartyl-L-phenylalanine methyl ester, it exceeds the solubility level of .alpha.-L-aspartyl-L-phenylalanine methyl ester in the mixture of the two aqueous solutions at the temperature of the mixture.
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公开(公告)号:DE69025352D1
公开(公告)日:1996-03-28
申请号:DE69025352
申请日:1990-05-19
Applicant: STAMICARBON , TOSOH CORP
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公开(公告)号:JPH02174650A
公开(公告)日:1990-07-06
申请号:JP32620088
申请日:1988-12-26
Applicant: TOSOH CORP
Inventor: SHIOKAWA YUTAKA , KUNISAWA YUKIO , HARADA TSUNEO
Abstract: PURPOSE:To prepare a granular dipeptide sweetener having high purity and excellent fluidity and solubility by spray-drying a slurry of a dipeptide sweetener without using a crushing operation, granulating the dried product and, as necessary, further drying the granules. CONSTITUTION:A slurry liquid containing crystals of an alpha-L-aspartyl-L- phenylalanine lower alkyl ester is spray-dried to obtain a dried product having extremely poor fluidity and containing a large amount of fusiform fine powder of
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公开(公告)号:JPH05286994A
公开(公告)日:1993-11-02
申请号:JP11846492
申请日:1992-04-13
Applicant: TOSOH CORP
Inventor: WAKAMATSU HIDETOSHI , HARADA TSUNEO , KUNISAWA YUKIO , KOYAMA KIYOTAKA
Abstract: PURPOSE:To crystallize a crystal of the subject compound having good filtrating property and dehydrating property by continuously feeding a hot water solution containing alpha-L-aspartyl-L-phenylalanine methyl ester to a crystallizing tank cooled to a temperature or below at which the compound is dissolved. CONSTITUTION:Whenalpha-L-aspartyl-L-phenylalanine methyl ester (A2PM) is crystallized from a hot water solution containing alpha-L-aspartyl-L-phenylalanine methyl ester by cooling, the crystallization of A2PM is carried out by continuously feeding a hot water solution in which the content of L-aspartyl-Laspartyl-L- phenylalanine methyl ester (A2PM) is 0.6% smaller than the of alpha-L-spartyl-L- phenylalanine methyl ester to a crystallizing tank cooled to a temperature or below at which alpha-L-aspartyl-L-phenylalanine methyl ester is dissolved and simultaneously continuously drawing out the produced slurry from the crystallizing tank.
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公开(公告)号:JPH03106899A
公开(公告)日:1991-05-07
申请号:JP24081989
申请日:1989-09-19
Applicant: TOSOH CORP
Inventor: HARADA TSUNEO , WAKAMATSU HIDETOSHI , KUNISAWA YUKIO , KOYAMA KIYOTAKA
Abstract: PURPOSE:To prepare crystals free from impurities and having good filterability and dehydrating ability by continuously feeding a hot aqueous solution of aspartylphenylalanine methyl ester into a crystallization tank cooled to a specific temperature and subsequently separating the produced slurry to remove impurities. CONSTITUTION:A hot aqueous solution (preferably 30-80 deg.C) of alpha-L-aspartyl-L- phenylalanine methyl ester containing
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