METHOD FOR CRYSTALLIZING &-L-ASPARTYL-L-PHENYLALANINE METHYL ESTER

    公开(公告)号:CA2017137A1

    公开(公告)日:1990-11-22

    申请号:CA2017137

    申请日:1990-05-18

    Abstract: - 14 - (14) AE 6335 A method for crystallizing .alpha.-L-aspartyl-L-phenyl-alanine methyl ester, which comprises mixing a hot aqueous solution containing .alpha.-L-aspartyl-L-phenylalanine methyl ester and a cold aqueous solution which may contain .alpha.-L-aspartyl-L-phenylalanine methyl ester, in such proportions that the concentration of .alpha.-L-aspartyl-L-phenylalanine methyl ester after mixing exceeds its solubility in the mixture of the two aqueous solutions at the temperature of the mixture, to precipitate crystals of .alpha.-L-aspartyl-L-phenylalanine methyl ester, and if necessary, cooling the mixture, the total amount of .alpha.-L-aspartyl-L-phenylalanine methyl ester contained in the hot and cold aqueous solutions being such that when the two aqueous solutions are mixed to precipitate crystals of .alpha.-L-aspartyl-L-phenylalanine methyl ester, it exceeds the solubility level of .alpha.-L-aspartyl-L-phenylalanine methyl ester in the mixture of the two aqueous solutions at the temperature of the mixture.

    PREPARATION OF GRANULAR DIPEPTIDE SWEETENER

    公开(公告)号:JPH02174650A

    公开(公告)日:1990-07-06

    申请号:JP32620088

    申请日:1988-12-26

    Applicant: TOSOH CORP

    Abstract: PURPOSE:To prepare a granular dipeptide sweetener having high purity and excellent fluidity and solubility by spray-drying a slurry of a dipeptide sweetener without using a crushing operation, granulating the dried product and, as necessary, further drying the granules. CONSTITUTION:A slurry liquid containing crystals of an alpha-L-aspartyl-L- phenylalanine lower alkyl ester is spray-dried to obtain a dried product having extremely poor fluidity and containing a large amount of fusiform fine powder of

    6.
    发明专利
    失效

    公开(公告)号:JPH05286994A

    公开(公告)日:1993-11-02

    申请号:JP11846492

    申请日:1992-04-13

    Applicant: TOSOH CORP

    Abstract: PURPOSE:To crystallize a crystal of the subject compound having good filtrating property and dehydrating property by continuously feeding a hot water solution containing alpha-L-aspartyl-L-phenylalanine methyl ester to a crystallizing tank cooled to a temperature or below at which the compound is dissolved. CONSTITUTION:Whenalpha-L-aspartyl-L-phenylalanine methyl ester (A2PM) is crystallized from a hot water solution containing alpha-L-aspartyl-L-phenylalanine methyl ester by cooling, the crystallization of A2PM is carried out by continuously feeding a hot water solution in which the content of L-aspartyl-Laspartyl-L- phenylalanine methyl ester (A2PM) is 0.6% smaller than the of alpha-L-spartyl-L- phenylalanine methyl ester to a crystallizing tank cooled to a temperature or below at which alpha-L-aspartyl-L-phenylalanine methyl ester is dissolved and simultaneously continuously drawing out the produced slurry from the crystallizing tank.

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