公开(公告)号：JPH0931010A

公开(公告)日：1997-02-04

申请号：JP18416895

申请日：1995-07-20

Applicant: UBE INDUSTRIES

Inventor： YOKOTA NAOYUKI ,  MIYATA HIROYUKI ,  YAMAMOTO YASUHITO ,  ATAKA KIKUO ,  HASHIMOTO YOICHI ,  BANNOU TADASHI ,  UMENO MASAYUKI

IPC: C07D333/22 ,  C07C45/45 ,  C07C45/48 ,  C07C49/563 ,  C07C49/567

Abstract: PROBLEM TO BE SOLVED: To industrially obtain in high yield the subject compound important as a raw material for producing medicines and agrochemicals (esp. medicines). SOLUTION: An arylacetic acid of the formula R CH2 COOH (I) [R is (alkyl- or halogen-substituted) phenyl or 2-thienyl] is reacted with a haloalkylmagnesium of the formula R MgX (II) (R is an alkyl; X is a halogen atom) in an organic solvent followed by reaction with a cyclopropanecarboxylic ester of the formula R COOR (III) [R is a (alkyl- or fluorine-substituted) cyclopropyl group; R is an alkyl] to obtain the objective aryl cyclopropyl ketone of the formula R CH2 COR (IV). In this case, 2.5-5mol equivalent of the Grignard reagent (II) based on the arylacetic acid (I) is used.