公开(公告)号：AU2014244926A1

公开(公告)日：2015-11-12

申请号：AU2014244926

申请日：2014-03-28

Applicant: UBE INDUSTRIES

Inventor： SHIBAKAWA NOBUHIKO ,  YONEDA KENJI ,  KATSUBE TETSUSHI ,  KANDA TOMOKO ,  ITO KOJI ,  YAMAMOTO KIYOSHI ,  IWASE NORIAKI ,  USHIYAMA SHIGERU

IPC: C07D213/74 ,  A61K31/4436 ,  A61K31/444 ,  A61P11/00 ,  A61P43/00 ,  C07D409/12

Abstract: The present invention provides a substituted biaryl compound represented by general formula (I) (wherein R

公开(公告)号：AU2014312704A1

公开(公告)日：2016-04-14

申请号：AU2014312704

申请日：2014-09-02

Applicant: UBE INDUSTRIES

Inventor： YONEDA KENJI ,  SHIBAKAWA NOBUHIKO ,  KATSUBE TETSUSHI ,  KANDA TOMOKO ,  ITO KOJI ,  YAMAMOTO KIYOSHI ,  SHINOHARA MASARU ,  IWASE NORIAKI ,  USHIYAMA SHIGERU

IPC: A61K31/44 ,  A61K31/4436 ,  A61K31/444 ,  A61P11/00

Abstract: Provided is a pharmaceutical composition containing, as an active ingredient, a substituted biaryl compound represented by general formula (I) (where R

公开(公告)号：CA2923016A1

公开(公告)日：2015-03-05

申请号：CA2923016

申请日：2014-09-02

Applicant: UBE INDUSTRIES

Inventor： YONEDA KENJI ,  SHIBAKAWA NOBUHIKO ,  KATSUBE TETSUSHI ,  KANDA TOMOKO ,  ITO KOJI ,  YAMAMOTO KIYOSHI ,  SHINOHARA MASARU ,  IWASE NORIAKI ,  USHIYAMA SHIGERU

IPC: A61K31/44 ,  A61K31/4436 ,  A61K31/444 ,  A61P11/00

Abstract: Provided is a pharmaceutical composition containing, as an active ingredient, a substituted biaryl compound represented by general formula (I) (where R1, W, R2, and Z are each as defined in the claims and the description), or a pharmaceutically acceptable salt thereof. The pharmaceutical composition according to the present invention exhibits a superior anti-inflammatory effect, and is effective as a drug and/or prophylactic against chronic obstructive pulmonary disease.

公开(公告)号：SG11201507976YA

公开(公告)日：2015-10-29

申请号：SG11201507976Y

申请日：2014-03-28

Applicant: UBE INDUSTRIES

Inventor： SHIBAKAWA NOBUHIKO ,  YONEDA KENJI ,  KATSUBE TETSUSHI ,  KANDA TOMOKO ,  ITO KOJI ,  YAMAMOTO KIYOSHI ,  IWASE NORIAKI ,  USHIYAMA SHIGERU

IPC: C07D213/74 ,  A61K31/4436 ,  A61K31/444 ,  A61P11/00 ,  A61P43/00 ,  C07D409/12

公开(公告)号：HK1219103A1

公开(公告)日：2017-03-24

申请号：HK16107171

申请日：2016-06-21

Applicant: UBE INDUSTRIES

Inventor： SHIBAKAWA NOBUHIKO ,  YONEDA KENJI ,  KATSUBE TETSUSHI ,  KANDA TOMOKO ,  ITO KOJI ,  YAMAMOTO KIYOSHI ,  IWASE NORIAKI ,  USHIYAMA SHIGERU

IPC: C07D20060101 ,  A61K20060101 ,  A61P20060101

公开(公告)号：CA2908223A1

公开(公告)日：2014-10-02

申请号：CA2908223

申请日：2014-03-28

Applicant: UBE INDUSTRIES

Inventor： SHIBAKAWA NOBUHIKO ,  YONEDA KENJI ,  KATSUBE TETSUSHI ,  KANDA TOMOKO ,  ITO KOJI ,  YAMAMOTO KIYOSHI ,  IWASE NORIAKI ,  USHIYAMA SHIGERU

IPC: C07D213/74 ,  A61K31/4436 ,  A61K31/444 ,  A61P11/00 ,  A61P43/00 ,  C07D409/12

Abstract: The present invention provides a substituted biaryl compound represented by general formula (I) (wherein R1, W, R2 and Z are as defined in the claims and the description) or a pharmacologically acceptable salt thereof. The compound according to the present invention has an excellent effect of inhibiting the proliferation of a pulmonary fibroblast, and is therefore useful as a therapeutic agent and/or a prophylactic agent for interstitial pneumonia and pulmonary fibrosis.

公开(公告)号：EP2980075A4

公开(公告)日：2016-08-10

申请号：EP14775434

申请日：2014-03-28

Applicant: UBE INDUSTRIES

Inventor： SHIBAKAWA NOBUHIKO ,  YONEDA KENJI ,  KATSUBE TETSUSHI ,  KANDA TOMOKO ,  ITO KOJI ,  YAMAMOTO KIYOSHI ,  IWASE NORIAKI ,  USHIYAMA SHIGERU

IPC: C07D213/74 ,  A61K31/4436 ,  A61K31/444 ,  A61P11/00 ,  A61P43/00 ,  C07D409/12

CPC classification number: C07D213/74 ,  C07D409/12

Abstract: The present invention provides a substituted biaryl compound of general formula (I): wherein, R 1 , W, R 2 , and Z are as defined in the claims and the description, or a pharmacologically acceptable salt thereof. The compound according to the present invention has an excellent inhibition effect of pulmonary fibroblast proliferation, and is therefore useful as a therapeutic agent and/or a prophylactic agent for interstitial pneumonia and pulmonary fibrosis.