公开(公告)号：CA2692085A1

公开(公告)日：2008-12-31

申请号：CA2692085

申请日：2008-06-24

Applicant: UCB PHARMA SA

Inventor： FRANKLIN RICHARD JEREMY ,  FOLEY ANNE MARIE ,  AUJLA PAVANDEEP SINGH ,  CREPY KAREN VIVIANE LUCILE ,  ALEXANDER RIKKI PETER

IPC: C07D513/04 ,  A61K31/437 ,  A61K31/519 ,  C07D513/12 ,  C07D519/00

Abstract: A series of 6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-4(5H)-one derivatives, which are substituted in the 2-position by a substituted morpholin-4-yl moi ety, being selective inhibitors of PI3 kinase enzymes, are accordingly of be nefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or o phthalmic conditions.

公开(公告)号：CY1114419T1

公开(公告)日：2016-08-31

申请号：CY131100552

申请日：2013-07-03

Applicant: UCB PHARMA SA

Inventor： ALEXANDER RIKKI PETER ,  AUJLA PAVANDEEP SINGH ,  CRÉPY KAREN VIVIANE LUCILE ,  FOLEY ANNE MARIE ,  FRANKLIN RICHARD JEREMY

IPC: C07D513/04 ,  A61K31/437 ,  A61K31/519 ,  C07D513/12 ,  C07D519/00

Abstract: Μιασειράπαραγώγων 6,7-διϋδρο-[1,3]θειαζολο[5,4-c]πυριδιν-4(5Η)-όνης, πουείναιυποκατεστημέναστηθέση 2 απόμιαυποκατεστημένημορφολιν-4-υλχαρακτηριστικήομάδα, ταοποίαείναιεκλεκτικοίαναστολείςενζύμωνκινάσηςΡΙ3, είναισυνεπώςευεργετικάστηνιατρική, γιαπαράδειγμαστηθεραπευτικήαγωγήφλεγμονωδών, αυτοάνοσων, καρδιαγγειακών, νευροεκφυλιστικών, μεταβολικών, ογκολογικών, αλγαισθητικώνκαιοφθαλμικώνκαταστάσεων.

公开(公告)号：PL2170906T3

公开(公告)日：2013-08-30

申请号：PL08775774

申请日：2008-06-24

Applicant: UCB PHARMA SA

Inventor： ALEXANDER RIKKI PETER ,  AUJLA PAVANDEEP SINGH ,  CRÉPY KAREN VIVIANE LUCILE ,  FOLEY ANNE MARIE ,  FRANKLIN RICHARD JEREMY

IPC: C07D513/04 ,  A61K31/437 ,  A61K31/519 ,  C07D513/12 ,  C07D519/00

公开(公告)号：CO6270229A2

公开(公告)日：2011-04-20

申请号：CO09149835

申请日：2009-12-31

Applicant: UCB PHARMA SA

Inventor： ALEXANDER RIKKI PETER ,  AUJLA PAVANDEEP SINGH ,  CREPY KAREN VIVIANE ,  FOLEY ANNE MARIE ,  FRANKLIN RICHARD JEREMY

IPC: A61K31/519 ,  C07D513/04 ,  C07D519/00

Abstract: Una serie de derivados de 6,7dihidro[1.3]tiazolo[5,4-c]piridin-4(5H)-ona, que se sustituyen en la posicion 2 por un resto morfolin-4-ilo sustituido, que son inhibidores selectivos de enzimas P13 quinasa, y son, por lo tanto beneficiosos en medicina, por ejemplo en el tratamiento de afecciones inflamatorias, autoinmunes, cardiovasculares, neurodegenerativas, metabolicas, oncologicas, nociceptivas u oftalmologicas. 1.- Un compuesto de formula (I), o una sal o un solvato farmacéuticamente aceptable del mismo:en donde R11 representa hidrogeno o alquilo C1-6; y R12 representa hidrogeno; o alquiloC1-6, alcoxiC1-6, cicloalquiloC3-7, cicloaIquilC3-7aIquilo(C1-6), arilo, arilalquilo(C1-6), heterocicloalquiloC3-7, heterocicloalquilC3-7-alquiloC1-6), heteroarilo o heteroarilalquilo(C1-6), pudiendo estar cualquiera de dichos grupos opcionalmente sustituido por uno o mas sustituyentes: oR11 y R12, tomados junto con el atomo de carbono al que ambos estan unidos, representan cicloalquiloC3-7 o heterocicloalquiloC3-7, pudiendo estar cualquiera de dichos grupos opcionalmente sustituido por uno o mas sustituyentes; T representa oxigeno o N-R25;V representa carbono o nitrogeno; W representa carbono o nitrogeno; R23 representa hidrogeno, halogeno, ciano. nitro, alquiIoC1-6, hidroxialquilo(C1-6), trifluorometilo, arilalquilo(C1-6), oxazolinilo, triazolilo, hidroxi, alcoxiC1-6, difluorometoxi, trifluorometoxi, cicloalcoxiC3-7, cicloalquilC3-7alcoxi(C1-6), morfolinilalcoxi(C1-6), ariloxi, arilalcoxi(C1-6), alquilC1-6tio, alquilC1-6sulfinilo, arilsulfinilo, arilsulfonilo, alquilC1-6sulfoniloxi, amino, azetidinilo, morfolinilo, alquilC2-6carbonilamino, alquilC2-6carbonilaminometilo, alcoxiC2-6carbonilamino, [alcoxi(C2-6)carbonil][alquil(C1-6)]amino, alquilC1-6sulfonilamino, alquilC2-6carbonilo, alquilC2-6carbonilo oxima, ...

公开(公告)号：AU2008269577A1

公开(公告)日：2008-12-31

申请号：AU2008269577

申请日：2008-06-24

Applicant: UCB PHARMA SA

Inventor： FRANKLIN RICHARD JEREMY ,  AUJLA PAVANDEEP SINGH ,  ALEXANDER RIKKI PETER ,  CREPY KAREN VIVIANE LUCILE ,  FOLEY ANNE MARIE

IPC: C07D513/04 ,  A61K31/437 ,  A61K31/519 ,  C07D513/12 ,  C07D519/00

Abstract: A series of 6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-4(5H)-one derivatives, which are substituted in the 2-position by a substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

公开(公告)号：BRPI0813777A2

公开(公告)日：2014-12-30

申请号：BRPI0813777

申请日：2008-06-24

Applicant: UCB PHARMA SA

Inventor： ALEXANDER RIKKI PETER ,  AUJLA PAVANDEEP SINGH ,  CREPY KAREN VIVIANE LUCILE ,  FOLEY ANNE MARIE ,  FRANKLIN RICHARD JEREMY

IPC: C07D513/04 ,  A61K31/437 ,  A61K31/519 ,  C07D513/12 ,  C07D519/00

Abstract: A series of 6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-4(5H)-one derivatives, which are substituted in the 2-position by a substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

公开(公告)号：UA99469C2

公开(公告)日：2012-08-27

申请号：UAA201000774

申请日：2008-06-24

Applicant: UCB PHARMA SA

Inventor： ALEXANDER RIKKI PETER ,  AUJLA PAVANDEEP SINGH ,  CREPY KAREN VIVIANE LUCILE ,  FOLEY ANNE MARIE ,  FRANKLIN RICHARD JEREMY

IPC: C07D513/04 ,  A61K31/437 ,  A61K31/519 ,  C07D513/12 ,  C07D519/06

Abstract: Серияпроизводных 6,7-дигидро[1,3]тиазоло[5,4-с]пиридин-4(5Н)-она, замещенныхв 2-позициигруппойзамещенногоморфолин-4-ила,гдерадикалыопределеныв описанииизобретения, которыеблагодарясвоимсвойствамселективныхингибиторовферментов PI3-киназыявляютсяполезнымидлямедицины, напримерприлечениивоспалительных, аутоиммунных, сердечно-сосудистых, нейродегенеративных, метаболических, онкологических, ноцицептивныхи офтальмическихсостояний.

公开(公告)号：NZ581919A

公开(公告)日：2011-08-26

申请号：NZ58191908

申请日：2008-06-24

Applicant: UCB PHARMA SA

Inventor： FRANKLIN RICHARD JEREMY ,  FOLEY ANNE MARIE ,  CREPY KAREN VIVIANE LUCILE ,  AUJLA PAVANDEEP SINGH ,  ALEXANDER RIKKI PETER

IPC: C07D513/04 ,  A61K31/437 ,  A61K31/519 ,  C07D513/12 ,  C07D519/00

Abstract: Disclosed is a fused thiazole derivative of formula (I), or a salt or solvate thereof, wherein T is O or NR25, V and W are each C or N, and the other substituents are as defined in the specification. An exemplary compound of this formula is 3-{ [(3S)-4-(6,6-Dimethyl-4-oxo-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)morpholin-3-yl]methyl} -N,N,1-trimethyl-1H-indole-5-carboxamide. Also disclosed is the use of the compound to treat a disorder for which the administration of a selective PI3K inhibitor is indicated, such as inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive and ophthalmic disorders.

公开(公告)号：HK1140756A1

公开(公告)日：2010-10-22

申请号：HK10107097

申请日：2010-07-23

Applicant: UCB PHARMA SA

Inventor： ALEXANDER RIKKI PETER ,  AUJLA PAVANDEEP SINGH ,  CREPY KAREN VIVIANE LUCILE ,  FOLEY ANNE MARIE ,  FRANKLIN RICHARD JEREMY

IPC: C07D20060101 ,  A61K20060101

Abstract: A series of 6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-4(5H)-one derivatives, which are substituted in the 2-position by a substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

公开(公告)号：SI2170906T1

公开(公告)日：2013-07-31

申请号：SI200830975

申请日：2008-06-24

Applicant: UCB PHARMA SA

Inventor： ALEXANDER RIKKI PETER ,  AUJLA PAVANDEEP SINGH ,  CREPY KAREN VIVIANE LUCILE ,  FOLEY ANNE MARIE ,  FRANKLIN RICHARD JEREMY

IPC: C07D513/00 ,  A61K31/00 ,  C07D519/00