公开(公告)号：MY162396A

公开(公告)日：2017-06-15

申请号：MYPI2013000767

申请日：2011-09-02

Applicant: UCB PHARMA SA

Inventor： PARTON ANDREW HARRY ,  ALI MEZHER HUSSEIN ,  BROOKINGS DNIEL CHRISTOPHER ,  BROWN JULIEN ALISTAR ,  FORD DANIEL JAMES ,  FRANKLIN RICHARD JEREMY ,  LANGHAM BARRY JOHN ,  NEUSS JUDI CHARLOTTE ,  QUINCEY JOANNA RACHEL

IPC: C07D471/04 ,  A61K31/519 ,  A61P9/00 ,  A61P25/28 ,  A61P29/00

Abstract: A SERIES OF QUINOLONE AND QUINOXALINE DERIVATIVES COMPRISING A FLUORINATED ETHYL SIDE-CHAIN, BEING SELECTIVE INHIBITORS OF PI3 KINASE ENZYMES, ARE ACCORDINGLY OF BENEFIT IN MEDICINE, FOR EXAMPLE IN THE TREATMENT OF INFLAMMATORY, AUTOIMMUNE, CARDIOVASCULAR, NEURODEGENERATIVE, METABOLIC, ONCOLOGICAL, NOCICEPTIVE OR OPHTHALMIC CONDITIONS.

公开(公告)号：CA2692085A1

公开(公告)日：2008-12-31

申请号：CA2692085

申请日：2008-06-24

Applicant: UCB PHARMA SA

Inventor： FRANKLIN RICHARD JEREMY ,  FOLEY ANNE MARIE ,  AUJLA PAVANDEEP SINGH ,  CREPY KAREN VIVIANE LUCILE ,  ALEXANDER RIKKI PETER

IPC: C07D513/04 ,  A61K31/437 ,  A61K31/519 ,  C07D513/12 ,  C07D519/00

Abstract: A series of 6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-4(5H)-one derivatives, which are substituted in the 2-position by a substituted morpholin-4-yl moi ety, being selective inhibitors of PI3 kinase enzymes, are accordingly of be nefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or o phthalmic conditions.

公开(公告)号：BRPI0813777A2

公开(公告)日：2014-12-30

申请号：BRPI0813777

申请日：2008-06-24

Applicant: UCB PHARMA SA

Inventor： ALEXANDER RIKKI PETER ,  AUJLA PAVANDEEP SINGH ,  CREPY KAREN VIVIANE LUCILE ,  FOLEY ANNE MARIE ,  FRANKLIN RICHARD JEREMY

IPC: C07D513/04 ,  A61K31/437 ,  A61K31/519 ,  C07D513/12 ,  C07D519/00

Abstract: A series of 6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-4(5H)-one derivatives, which are substituted in the 2-position by a substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

公开(公告)号：TN2013000080A1

公开(公告)日：2014-06-25

申请号：TN2013000080

申请日：2013-02-28

Applicant: UCB PHARMA SA

Inventor： PARTON ANDREW HARRY ,  ALI MEZHER HUSSEIN ,  BROOKINGS DANIEL CHRISTOPHER ,  BROWN JULIEN ALISTAIR ,  FORD DANIEL JAMES ,  FRANKLIN RICHARD JEREMY ,  LANGHAM BARRY JOHN ,  NEUSS JUDI CHARLOTTE ,  QUINCEY JOANNA RACHEL

IPC: A61K31/519 ,  A61P9/00 ,  A61P25/28 ,  A61P29/00 ,  C07D471/04

公开(公告)号：AU2011300521A1

公开(公告)日：2013-04-04

申请号：AU2011300521

申请日：2011-09-02

Applicant: UCB PHARMA SA

Inventor： PARTON ANDREW HARRY ,  ALI MEZHER HUSSEIN ,  BROOKINGS DANIEL CHRISTOPHER ,  BROWN JULIEN ALISTAIR ,  FORD DANIEL JAMES ,  FRANKLIN RICHARD JEREMY ,  LANGHAM BARRY JOHN ,  NEUSS JUDI CHARLOTTE ,  QUINCEY JOANNA RACHEL

IPC: C07D471/04 ,  A61K31/519 ,  A61P9/00 ,  A61P25/28 ,  A61P29/00

Abstract: A series of quinoline and quinoxaline derivatives comprising a fluorinated ethyl side-chain, being selective inhibitors of P13 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

公开(公告)号：UA99469C2

公开(公告)日：2012-08-27

申请号：UAA201000774

申请日：2008-06-24

Applicant: UCB PHARMA SA

Inventor： ALEXANDER RIKKI PETER ,  AUJLA PAVANDEEP SINGH ,  CREPY KAREN VIVIANE LUCILE ,  FOLEY ANNE MARIE ,  FRANKLIN RICHARD JEREMY

IPC: C07D513/04 ,  A61K31/437 ,  A61K31/519 ,  C07D513/12 ,  C07D519/06

Abstract: Серияпроизводных 6,7-дигидро[1,3]тиазоло[5,4-с]пиридин-4(5Н)-она, замещенныхв 2-позициигруппойзамещенногоморфолин-4-ила,гдерадикалыопределеныв описанииизобретения, которыеблагодарясвоимсвойствамселективныхингибиторовферментов PI3-киназыявляютсяполезнымидлямедицины, напримерприлечениивоспалительных, аутоиммунных, сердечно-сосудистых, нейродегенеративных, метаболических, онкологических, ноцицептивныхи офтальмическихсостояний.

公开(公告)号：NZ581919A

公开(公告)日：2011-08-26

申请号：NZ58191908

申请日：2008-06-24

Applicant: UCB PHARMA SA

Inventor： FRANKLIN RICHARD JEREMY ,  FOLEY ANNE MARIE ,  CREPY KAREN VIVIANE LUCILE ,  AUJLA PAVANDEEP SINGH ,  ALEXANDER RIKKI PETER

IPC: C07D513/04 ,  A61K31/437 ,  A61K31/519 ,  C07D513/12 ,  C07D519/00

Abstract: Disclosed is a fused thiazole derivative of formula (I), or a salt or solvate thereof, wherein T is O or NR25, V and W are each C or N, and the other substituents are as defined in the specification. An exemplary compound of this formula is 3-{ [(3S)-4-(6,6-Dimethyl-4-oxo-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)morpholin-3-yl]methyl} -N,N,1-trimethyl-1H-indole-5-carboxamide. Also disclosed is the use of the compound to treat a disorder for which the administration of a selective PI3K inhibitor is indicated, such as inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive and ophthalmic disorders.

公开(公告)号：HK1140756A1

公开(公告)日：2010-10-22

申请号：HK10107097

申请日：2010-07-23

Applicant: UCB PHARMA SA

Inventor： ALEXANDER RIKKI PETER ,  AUJLA PAVANDEEP SINGH ,  CREPY KAREN VIVIANE LUCILE ,  FOLEY ANNE MARIE ,  FRANKLIN RICHARD JEREMY

IPC: C07D20060101 ,  A61K20060101

Abstract: A series of 6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-4(5H)-one derivatives, which are substituted in the 2-position by a substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

公开(公告)号：CA2808959C

公开(公告)日：2018-07-17

申请号：CA2808959

申请日：2011-09-02

Applicant: UCB PHARMA SA

Inventor： PARTON ANDREW HARRY ,  ALI MEZHER HUSSEIN ,  BROOKINGS DANIEL CHRISTOPHER ,  BROWN JULIEN ALISTAIR ,  FORD DANIEL JAMES ,  FRANKLIN RICHARD JEREMY ,  LANGHAM BARRY JOHN ,  NEUSS JUDI CHARLOTTE ,  QUINCEY JOANNA RACHEL

IPC: C07D471/04 ,  A61K31/519 ,  A61P9/00 ,  A61P25/28 ,  A61P29/00

Abstract: A series of quinoline and quinoxaline derivatives comprising a fluorinated ethyl side-chain, being selective inhibitors of P13 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

公开(公告)号：CA2692085C

公开(公告)日：2015-10-13

申请号：CA2692085

申请日：2008-06-24

Applicant: UCB PHARMA SA

Inventor： ALEXANDER RIKKI PETER ,  AUJLA PAVANDEEP SINGH ,  CREPY KAREN VIVIANE LUCILE ,  FOLEY ANNE MARIE ,  FRANKLIN RICHARD JEREMY

IPC: C07D513/04 ,  A61K31/437 ,  A61K31/519 ,  C07D513/12 ,  C07D519/00

Abstract: A series of 6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-4(5H)-one derivatives of (see formula I) which are substituted in the 2-position by a substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.