公开(公告)号：AT541590T

公开(公告)日：2012-02-15

申请号：AT04743216

申请日：2004-07-01

Applicant: UCB PHARMA SA

Inventor： HUMPHREYS DAVID PAUL ,  HEYWOOD SAM PHILIP ,  CARRINGTON BRUCE

IPC: A61K47/48 ,  C07K16/24 ,  C07K16/28

Abstract: The present invention provides an antibody Fab or Fab' fragment to which at least one effector molecule is attached characterized in that the heavy chain in the fragment is not covalently bonded to the light chain and both the interchain cysteine of C L and the interchain cysteine of C H 1 have been replaced with another amino acid.

公开(公告)号：AU2004253746A1

公开(公告)日：2005-01-13

申请号：AU2004253746

申请日：2004-07-01

Applicant: UCB PHARMA SA

Inventor： HUMPHREYS DAVID PAUL ,  HEYWOOD SAM PHILIP ,  CARRINGTON BRUCE

IPC: A61K47/48 ,  C07K16/24 ,  C07K16/28

Abstract: The present invention provides an antibody Fab or Fab' fragment to which at least one effector molecule is attached characterized in that the heavy chain in the fragment is not covalently bonded to the light chain and both the interchain cysteine of C L and the interchain cysteine of C H 1 have been replaced with another amino acid.