公开(公告)号：CA2620362A1

公开(公告)日：2007-03-22

申请号：CA2620362

申请日：2006-09-12

Applicant: UCB PHARMA SA

Inventor： ALI MEZHER HUSSEIN ,  NORMAN TIMOTHY JOHN ,  DE CANDOLE BENJAMIN CHARLES

IPC: C08F2/38 ,  A61K47/48 ,  C08F8/04 ,  C08F8/32 ,  C08F120/36

Abstract: The present invention provides a process for producing a comb polymer comprising the steps of : a) providing: (i) (w+z) molar equivalents of a monomer; (ii) one molar equivalent of an initiator compound of formula (IX), wherein B3 represents a halogen, B2 represents H or a halogen, Y1 represents a group capable of attaching the residue of an antibody or fragment thereof or capable of being converted into such a group, L represents a linker group, y is 1, 2 or 3, w is at least 1 and z is 0 or greater; (iii) a catalyst capabl e of catalysing the polymerisation of a plurality of the monomers to produce t he comb polymer; and b) causing the catalyst to catalyse, in combination with t he initiator, the polymerisation of a plurality of the monomers (i) to produce the comb polymer.