公开(公告)号：WO2008020206A2

公开(公告)日：2008-02-21

申请号：PCT/GB2007003114

申请日：2007-08-15

Applicant: UCB PHARMA SA ,  LAING VICTORIA ELIZABETH ,  BROOKINGS DANIEL CHRISTOPHER ,  CARBERY RACHEL JANE ,  GASCON SIMORTE JOSE MIGUEL ,  HUTCHINGS MARTIN CLIVE ,  LANGHAM BARRY JOHN ,  LOWE MARTIN ALEXANDER

Inventor： LAING VICTORIA ELIZABETH ,  BROOKINGS DANIEL CHRISTOPHER ,  CARBERY RACHEL JANE ,  GASCON SIMORTE JOSE MIGUEL ,  HUTCHINGS MARTIN CLIVE ,  LANGHAM BARRY JOHN ,  LOWE MARTIN ALEXANDER

IPC: C07D495/04 ,  A61K31/55 ,  A61P9/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00

CPC classification number: C07D495/04

Abstract: A series of 4,5,6,7-tetrahydrothieno[2,3-c]azepin-8-one derivatives, and analogues thereof, which are substituted in the 2-position by a substituted anilino moiety, being selective inhibitors of human MEK (MAPKK) enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, proliferative (including oncological) and nociceptive conditions.

Abstract translation: 一系列4,5,6,7-四氢噻吩并[2,3-c]吖庚因-8-酮衍生物及其类似物，其在2-位被取代的苯胺基部分取代，是人MEK的选择性抑制剂 （MAPKK）酶相应地在医学中有益，例如在治疗炎症，自身免疫，心血管，增殖（包括肿瘤）和伤害性疾病）中。

公开(公告)号：AU2004285752A1

公开(公告)日：2005-05-12

申请号：AU2004285752

申请日：2004-10-22

Applicant: UCB PHARMA SA

Inventor： HUTCHINGS MARTIN CLIVE ,  TREVITT GRAHAM PETER ,  ALEXANDER RIKKI PETER ,  LAING VICTORIA ELIZABETH ,  DAVIS JEREMY MARTIN

IPC: C07D495/04

Abstract: A series of thieno[2,3-b]pyridin-6(7H)-one derivatives, substituted in the 3-position by an arylcarbonyl or heteroaryl-carbonyl moiety, being inhibitors of p38 MAP kinase, are accordingly of use in medicine, for example in the treatment and/or prevention of immune or inflammatory disorders.